In 1857 the Livermores removed to Chicago. Mrs. Livermore while there aided in editing the New Covenant, a religious paper, at the same time writing stories and sketches for many Eastern publications. In 1860, when Abraham Lincoln was nominated for the Presidency, Mrs. Livermore was the only woman present,—probably the first woman representative of the press who ever reported a political convention.

The breaking out of the Civil War changed her life of domestic quietness to public activity. Being in Boston at the time that the President called for volunteer troops, she witnessed their departure for the seat of war. The sad scenes at the station, where mothers parted from sons, and wives from their husbands, affected her strongly. As the train carrying the soldiers started off, some of the women fainted. Mrs. Livermore helped to revive them, telling them not to grieve, but rather to be thankful that they had sons to fight for their country. For her part, she told them, she grieved to have no son to send.

Then a question arose in her mind: What could women do to help? The general feeling seemed to be that women could do nothing, since they were not allowed to enlist and fight as soldiers. They were told they were not wanted in the hospitals, but notwithstanding this a large number of women banded together and formed "The United States Sanitary Commission," whose object was to provide bedding, clothing, food, and comforts for the soldiers in camp, and supplies for the wounded in the hospitals.

Branch associations were formed in ten large cities. Mrs. Livermore and Mrs. Jane C. Hoge were put in charge of the Northwestern branch. Together with others Mrs. Livermore went to Washington to talk with President Lincoln. They asked him the question, "May women go to the front?"

Lincoln replied, "The law does not grant to any civilian, either man or woman, the privilege of going to the front."

The emphasis he placed upon the words law and grant convinced these women that he would not disapprove of their plans. So Mrs. Livermore entered hand, heart and soul into the work of relief.

The North was entirely unprepared for war. The hospitals were few and poorly equipped; nurses were scarce and not well trained; there were no diet kitchens; nor was there any way of supplying proper medicines to the sick or of caring for the wounded. To all of these matters Mrs. Livermore gave her attention; the confusion came to an end, and soon the machinery of the new department was running smoothly.

She formed soldiers' aid societies; enlisted nurses for the hospitals and took them to their posts; she went to the front with supplies, and saw that they were properly distributed; she nursed and cheered the wounded soldiers, and often brought back invalids with her to their homes. With all this work, she kept cheerful and well, and found time to write letters of comfort and cheer to the families of the sick. In one year she wrote seventeen hundred letters, many being from dying soldiers, and containing their last farewell to loved ones at home.

The Sanitary Commission was permitted in time of battle to keep its wagons in the rear of the army. Hot soup and hot coffee were kept in readiness, cool water and medicines were given when necessary, while the mere fact that brave women were ready to assist the wounded, put confidence into the hearts of the men.