Giant brains; or, Machines that think

by Edmund Callis Berkeley

We know also that thinking in the human brain is done essentially by a process of storing information and then referring to it, by a process of learning and remembering. We know that there are no little wheels in the brain so that a wheel standing at 2 can be turned 3 more steps and the result of 5 read. Instead, you and I store the information that 2 and 3 are 5, and store it in such a way that we can give the answer when questioned. But we do not know the register in our brain where this particular piece of information is stored. Nor do we know how, when we are questioned, we are able automatically to pick up the nerve channels that lead into this register, get the answer, and report it.

Since there are many nerves in the brain, about 10 billion of them, in fact, we are certain that the network of connecting nerves is a main part of the puzzle. We are therefore much interested in nerves and their properties.

NERVES AND THEIR PROPERTIES

A single nerve, or nerve cell, consists of a cell nucleus and a fiber. This fiber may have a length of anything from a small fraction of an inch up to several feet. In the laboratory, successive impulses can be sent along a nerve fiber as often as 1000 a second. Impulses can travel along a nerve fiber in either direction at a rate from 3 feet to 300 feet a second. Because the speed of the impulse is far less than 186,000 miles a second—the speed of an electric current—the impulse in the nerve is thought by some investigators to be more chemical than electrical.

We know that a nerve cell has what is called an all-or-none response, like the trigger of a gun. If you stimulate the nerve up to a certain point, nothing will happen; if you reach that point, or cross it,—bang!—the nerve responds and sends out an impulse. The strength of the impulse, like the shot of the gun, has no relation whatever to the amount of the stimulation.

Fig. 1. Scheme of a nerve cell.

The structure between the end of one nerve and the beginning of the next is called a synapse ([see Fig. 1]). No one really knows very much about synapses, for they are extremely small and it is not easy to tell where a synapse stops and other stuff begins. Impulses travel through synapses in from ½ to 3 thousandths of a second. An impulse travels through a synapse only in one direction, from the head (or axon) of one nerve fiber to the foot (or dendrite) of another. It seems clear that the activity in a synapse is chemical. When the head of a nerve fiber brings in an impulse to a synapse, apparently a chemical called acetylcholine is released and may affect the foot of another fiber, thus transmitting the impulse; but the process and the conditions for it are still not well understood.

It is thought that nearly all information is handled in the brain by groups of nerves in parallel paths. For example, the eye is estimated to have about 100 million nerves sensitive to light, and the information that they gather is reported by about 1 million nerves to the part of the brain that stores sights.

Not much more is yet known, however, about the operation of handling information in a human brain. We do not yet know how the nerves are connected so that we can do what we do. Probably the greatest obstacle to knowledge is that so far we cannot observe the detailed structure of a living human brain while it performs, without hurting or killing it.