bound > fated, compelled [by the heavens] life's despite > [life's malicious circumstances; or, perhaps: scorning, defiant of, life]

5 Yet can they not warn death from wretched wight.

warn death from > refuse death to [a] wight > mortal, woman

6 Come then, come soon, come sweetest death to me, 7 And take away this long lent loathed light: 8 Sharp be your wounds, but sweet the medicines be, 9 That long captived souls from weary thraldom free.

thraldom > captivity, bondage

201.37

But thou, sweet Babe, whom frowning froward fate
2 Hath made sad witnesse of thy fathers fall,
Sith heauen thee deignes to hold in liuing state,
4 Long maist thou liue, and better thriue withall,
Then to thy lucklesse parents did befall:
6 Liue thou, and to thy mother dead attest,
That cleare she dide from blemish criminall;
8 Thy litle hands embrewd in bleeding brest
Loe I for pledges leaue. So giue me leaue to rest.

1 "But you, sweet babe, whom frowning froward Fate

froward > perverse; adverse; evilly disposed

2 Has made sad witness of your father's fall, 3 Sith heaven you deigns to hold in living state,