A.D. 1566, a pestilence began at Comorra, called in Latin ‘Morbus Hungaricus’ and ‘Lues Pannonica.’ The Emperor Maximilian’s army, while carrying on hostilities against the Turks, lost many thousands by this disease. The symptoms were as follow:

It began generally in the latter part of the day, towards evening, with cold shiverings, succeeded in a short time by great heat and insatiable thirst, lasting for some hours. There was pain in the head and stomach. On the second, or third day at furthest, delirium set in. The tongue was dry and black; the teeth were covered with sordes: some spit blood; others suffered from diarrhœa. The sufferers generally were covered with spots like flea-bites, chiefly on the breast. Stoppage of the urine was considered a fatal sign. A similar spotted fever was also prevalent at Paris the year following, 1567, carrying off great numbers; it raged in many parts of Europe, continuing for three years: it subsequently degenerated into a dreadful pestilence—the true plague, and prevailed for the four following years.

A.D. 1568, Seville was visited by epidemic pestilence. Dr. Andres Zamudio de Alfaro wrote a treatise on this malady, as did also Francisco Franco, a native of Xativa, in the kingdom of Valencia, physician to his Serene Highness the King of Portugal. Franco in his work, alluding to the celebrated poet Ausias March, whose work he says should be written in letters of gold, quotes the following therefrom:

“Merge scient no te locas per joch

Com la calor no surt à part estrema

Lignorant veu que lo malat no crema

He jutial sa puix que mostra bon toch,

Lo pacient no podra dir son mal

Tot aflebit ab llengua mal diserta

Gest è color asats fan descuberta