It is my impression that, with rare exceptions, people are born with actual structural weaknesses, local or general, that may be called ancestral legacies. These are known as constitutional tendencies to disease.

In parts structurally weak at birth the bloodvessels, because of thin and weak walls, are larger than in normal parts, and because of dilatation the blood circulates slower. There is an undue pressure upon all between-vessel structures, a pressure that must lessen the nutrient supply more or less, according to its degree. The death of parts in boils and abscesses is due, I believe, to strangulation of the nerve-supply. The bloodvessels are elastic, and capable of contraction and dilatation, a matter regulated by the brain.

Now in these weaknesses always lie the possibilities of disease; they may be supposed the weak links in the constitutional chain, and can no more be made stronger than the constitutional design than can the body as a whole. By whatever means brain power is lessened abnormality is incited in the weak parts; hence gradually from the original weakness there is a summing up, as a bronchial or nasal catarrh, or other acute or chronic local or general disease.

The first step in any disease is the impression that lessens brain power; the slightest depressing emotion, the slightest sense of discomfort, lessens brain power, and to a like degree the tone of all the bloodvessels; hence dilatation in degree. That the stomach, as the most abused organ of the body, plays the largest part in over-drafts upon the brain is not a matter of doubt.

Let us develop a chronic disease along these lines, with nasal catarrh for an illustration. As tone is regulated entirely by the brain system, all taxing of the brain increases the debility of the nasal structures. In course of time the debility so increases through whatever also debilitates the brain, that a stage is reached when water in the blood begins to escape through the thin walls of the vessels and mingles with the natural secretion of the membrane, and a catarrhal discharge is the result. In severe cases a time may be reached when death of parts from the strangling pressure may occur, and then we have an ulcerative catarrh.

This evolution will go on as determined by the gravity of the ancestral weakness, by the natural strength of the dynamo, the brain, and the severity of the debilitating forces to which it may be subjected.

No one is ever attacked by a nasal or any other catarrh, nor by any other chronic ailings. They all start from structural weaknesses that are inherited, and they are the evolutionary results of brain-wearying forces.

If a specialist were asked to express the actual condition of a diseased structure that seems to call for medicinal aid, and to tell just how medicated sprays, washes, and douches are to reach all the parts involved, with healing power, and in what way that power is exercised—in other words, what work actually is to be done, and how medicine is to do it—he would not be able to enlighten his questioner no matter how fertile his conception, how dexterous his use of language. In fact, the healing power of drugs exists in fertile imaginations rather than among those ultimate processes where disease is cured, where disease destroys.

As the care moves by the power evolved in the dynamo, so do the bloodvessels contract and relax as determined by brain conditions. Dilating bloodvessels, effusion of water from thinning walls, the between-vessels starving pressure, increasing general debility of all the structures involved—this is the gradual evolution of catarrh and of all other chronic diseases.

From this it was seen that no form of local treatment can avail to relieve the operative cause in cases of this kind. Tone must be added to all the weakened, dilated vessels, in order to contract and thicken their walls so as to stop the leakage, and to relieve that pressure upon the between structures that have become anæmic through lack of nourishment.