Others have imagined that intemperance, poor living, foul habits and personal uncleanliness sow the seeds of crétinism; and this opinion is entitled to full consideration. Intemperance of divers kinds is fruitful in the production of insanity, and herding together in filthy dwellings, with little or no ventilation, may possibly deteriorate physique, as much as extreme indulgence may the mind. These ideas are popularly entertained, because crétins are more numerous among the lower orders than among the well-to-do classes. Yet they must, each and all, be regarded as inadequate to account for the disease, still less to explain its excess in the centre of the valley; for in these respects there is little or no distinction between it, the two extremities and the neighboring districts.

A conjecture remains to be considered regarding the origin of crétinism which is floating in the minds of many persons (although it is seldom expressed), which carries with it an air of probability that is wanting in the other explanations, and which is supported by admitted facts.

The fertility of the valley of Aosta is proverbial. It is covered with vineyards and cornfields, flocks and herds abound in it, and its mineral resources are great. There is enough and to spare both for man and beast. There are poor in the valley, as there are everywhere, but life is so far easy that they are not driven to seek for subsistence in other places, and remain from generation to generation rooted to their native soil. The large numbers of persons who are found in this valley having the same surnames is a proof of the well-known fact that there is little or no emigration from the valley, and that there is an indefinite amount of intermarriage between the natives. It is conjectured that the continuance of these conditions through a long period has rendered the population more or less consanguineous, and that we see in crétinism an example; upon a large scale, of the evil effects of alliances of kindred.

This explanation commends itself by reason of its general applicability to crétinism. The disease is commonly found in valleys, on islands or in other circumscribed areas in which circulation is restricted or the inhabitants are non-migratory; and it is rare on plains, where communications are free. It will at once be asked, “Why, then, are not the tributary valleys of the valley of Aosta full of crétins?” The answer is, that these lateral valleys are comparatively sterile, and are unable to support their population from their internal resources. Large numbers annually leave and do not return—some come back, having formed alliances elsewhere. There is a constant circulation and introduction of new blood. I am not aware that there are returns to show the extent to which this goes on, but the fact is notorious.

This conjecture explains, far better than the other guesses, why it is that crétinism has so strong a hold upon the lower classes, while it leaves the upper ones almost untouched; for the former are most likely to intermarry with people of their own district, whilst the latter are under no sort of compulsion in this respect. It gives a clue, too, to the reason of the particular intensity in the centre of the valley. The inhabitants of the lower extremity communicate and mix with the untainted dwellers on the plains, whilst the conditions at the upper extremity approximate to those of the lateral valleys. Before this explanation will be generally received a closer connection will have to be established between the assumed cause and the presumed effect. Accepting it, nevertheless, as a probable and reasonable one, let us now consider what prospect there is of checking the progress of the disease.

It is, of course, impossible to change the habits of the natives of the valley of Aosta suddenly, and it would probably be very difficult to cause any large amount of emigration or immigration. In the present embarrassed condition of Italian finances there is very small chance of any measure of the sort being undertaken if it would involve a considerable expenditure. The opening of a railway from Ivrea to Aosta might possibly bring about, in a natural way, more movement than would be promoted by any legislation, and by this means the happiest effects might be produced.

There is little hope of practical results from attempts to cure crétins. Once a crétin, you are always one. The experiments of the late Dr. Guggenbühl demonstrated that some half-crétins may even become useful members of society if they are taken in hand early in life, but they did not show that the nature of the true or complete crétin could be altered. He essayed to modify some of the mildest forms of crétinism, but did not strike at the root of the evil. If fifty Guggenbühls were at work in the single valley of Aosta, they would take several generations to produce an appreciable effect, and they would never extirpate the disease so long as its sources were unassailed.

Nor will the house which has been built at Aosta to contain two hundred crétin beggars do much, unless the inmates are restrained from perpetuating their own degradation. Even the lowest types of crétins may be procreative, and it is said that the unlimited liberty which is allowed to them has caused infinite mischief. A large proportion of the crétins who will be born in the next generation will undoubtedly be offspring of crétin parents. It is strange that self-interest does not lead the natives of Aosta to place their crétins under such restrictions as would prevent their illicit intercourse; and it is still more surprising to find the Catholic Church actually legalizing their marriage. There is something horribly grotesque in the idea of solemnizing the union of a brace of idiots; and since it is well known that the disease is hereditary, and develops in successive generations, the fact that such marriages are sanctioned is scandalous and infamous.

The supply, therefore, is kept up from two sources. The first contingent is delved from apparently healthy parents; the second, by inheritance from diseased persons. The origin of the first is obscure; and before its quota can be cut off, or even diminished, the mystery which envelops it must be dissipated. The remedy for the second is obvious, and is in the hands of the authorities, particularly in those of the clergy. Marriage must be prohibited to all who are affected, the most extreme cases must be placed under restraint, and crétins whose origin is illegitimate must be subject to disabilities. Nothing short of the adoption of these measures will meet the case. Useless it will be, so long as the primary sources of the disease are untouched, to build hospitals, to cleanse dwellings, to widen streets, or to attempt small ameliorations of the social circumstances of the natives. All of these things are good enough in themselves, but they are wholly impotent to effect a radical change.

No satisfactory conclusion will be arrived at regarding the origin of crétinism until the pedigrees of a large number of examples have been traced. The numerical test is the only one which is likely to discover the reality. The necessary inquiries are beyond the powers of private persons, and their pursuit will be found sufficiently difficult by official investigators. Great reluctance will be exhibited to disclose the information which should be sought, and the common cry will certainly be raised that such scrutiny is without general advantage and is painful to private feelings. But in matters which affect mankind in general, individual feelings must always be subordinated to the public interest; and if the truth is to be arrived at in regard to crétinism, the protests of the ignorant will have to be overridden.