1595—In 1595 the Spanish navigator Sebastian Rodriguez Cermeno is wrecked in Francis Drake's Bay, to which he gives the name Bay of San Francisco. This was a small bay behind Point Reyes, north of the entrance to the Golden Gate.

1602—Cabrillo's Port of San Miguel entered in 1602 by the Spanish navigator Sebastian Vizcaino, with four vessels: the San Diego (Saint James), the Santo Tomas (Saint Thomas), the Tres Reyes (Three Kings), and a launch. He christens the bay San Diego. Voyaging further, he rediscovers the Port of San Lucas, and christens it Monterey, in honor of the Count of Monterey, the ruler for Spain in Mexico.

1769—Sent out by Comandante José de Galvez, inspector general for Spain in Mexico, in 1769 the first expedition by land ascends from Lower California of Mexico into Alta (Upper) California. It is in two parties, one commanded by Captain Rivera y Moncada and accompanied by the Franciscan priest Padre Juan Crespi, the other commanded by Gaspar de Portola, governor of the Californias for Spain, and accompanied by the Franciscan priest Padre Junipero Serra. The object was to establish three Franciscan missions—one at San Diego, one at Monterey, one at San Francisco; and at Monterey a town and a fort. By sea set forth, with another expedition, and with supplies, the ships San Carlos (Saint Charles), San Antonio (Saint Anthony), and San José (Saint Joseph). The San José was disabled at the start. The meeting place was to be San Diego. Here, July 16, 1769, the mission of San Diego de Arcala is founded.

1769—November 2, 1769, the present Bay of San Francisco is discovered, from a hill, by some soldiers in the party of Gaspar de Portola, who had led an expedition northward from San Diego, to search for Monterey.

1770—June 3, 1770, the mission of San Carlos Borromeo de Monterey is founded. Three other missions follow, to September, 1772.

1776—September 17, 1776, the presidio or military station of San Francisco is founded.

1776—October 9, 1776, the mission of San Francisco de Asis is dedicated, on the shore of the real San Francisco Bay. By August 23, 1823, twenty-one missions have been placed.

1781—September 4, 1781, the town of Los Angeles is established.

1794—In 1794, as old records say, the first American arrived, landing from a ship and settling in Santa Barbara. He is called by the Californians, "Boston Boy."

1804—Upper California is made a separate Spanish province, by royal decree of August 29, 1804.