2. But as all excessive stimuli exhaust the sensorial power, and render the system less excitable for a time till the quantity of sensorial power is restored by sleep, or by the diminution or absence of stimulus; which is seen by the weakness of inebriates for a day at least after intoxication. And as the frequent repetition of this great and unnatural stimulus of fermented liquors produces a permanent debility, or disobedience of the system to the usual and natural kinds and quantities of stimulus, as occurs in those who have long been addicted to the ingurgitation of fermented liquors.

And as, secondly, the too great deficiency of the quantity of natural stimuli, as of food, and warmth, or of fresh air, produces also diseases; as is often seen in the children of the poor in large towns, who become scrofulous from want of due nourishment, and from cold, damp, unairy lodgings.

The great and principal means to prevent the approach of old age and death, must consist in the due management of the quantity of every kind of stimulus, but particularly of that from objects external to the moving organ; which may excite into action too great or too small a quantity of the sensorial power of irritation, which principally actuates the vital organs. Whence the use of much wine, or opium, or spice, or of much salt, by their unnatural stimulus induces consequent debility, and shortens life, on the one hand, by the exhaustion of sensorial power; so on the other hand, the want of heat, food, and fresh air, induces debility from defect of stimulus, and a consequent accumulation of sensorial power, and a general debility of the system. Whence arise the pains of cold and hunger, and those which are called nervous; and which are the cause of hysteric, epileptic, and perhaps of asthmatic paroxysms, and of the cold fits of fever.

3. Though all excesses of increase and decrease of stimulus should be avoided, yet a certain variation of stimulus seems to prolong the excitability of the system; as during any diminution of the usual quantity of stimulus, an accumulation of sensorial power is produced; and in consequence the excitability, which was lessened by the action of habitual stimulus, becomes restored. Thus those, who are uniformly habituated to much artificial heat, as in warm parlours in the winter months, lose their irritability in some degree, and become feeble like hot-house plants; but by frequently going for a time into the cold air, the sensorial power of irritability is accumulated and they become stronger.

Whence it may be deduced, that the variations of the cold and heat of this climate contribute to strengthen its inhabitants, who are more active and vigorous, and live longer, than those of either much warmer or much colder latitudes.

This accumulation of sensorial power from diminution of stimulus any one may observe, who in severe weather may sit by the fire-side till he is chill and uneasy with the sensation of cold; but if he walks into the frosty air for a few minutes, an accumulation of sensorial power is produced by diminution of the stimulus of heat, and on his returning into the room where he was chill before, his whole skin will now glow with warmth.

Hence it may be concluded, that the variations of the quantity of stimuli within certain limits contribute to our health; and that those houses which are kept too uniformly warm, are less wholesome than where the inhabitants are occasionally exposed to cold air in passing from one room to another.

Nevertheless to those weak habits with pale skins and large pupils of the eyes, whose degree of irritability is less than health requires, as in scrofulous, hysterical, and some consumptive constitutions, a climate warmer than our own may be of service, as a greater stimulus of heat may be wanted to excite their less irritability. And also a more uniform quantity of heat may be serviceable to consumptive patients than is met with in this country, as the lungs cannot be clothed like the external skin, and are therefore subject to greater extremes of heat and cold in passing in winter from a warm room into the frosty air.

4. It should nevertheless be observed, that there is one kind of stimulus, which though it be employed in quantity beyond its usual state, seems to increase the production of sensorial power beyond the expenditure of it (unless its excess is great indeed) and thence to give permanent strength and energy to the system; I mean that of volition. This appears not only from the temporary strength of angry or insane people, but because insanity even cures some diseases of debility, as I have seen in dropsy, and in some fevers; but it is also observable, that many who have exerted much voluntary effort during their whole lives, have continued active to great age. This however may be conceived to arise from these great exertions being performed principally by the organs of sense, that is by exciting and comparing ideas; as in those who have invented sciences, or have governed nations, and which did not therefore exhaust the sensorial power of those organs which are necessary to life, but perhaps rather prevented them from being sooner impaired, their sensorial power not having been so frequently exhausted by great activity, for very violent exercise of the body, long continued, forwards old age; as is seen in post-horses that are cruelly treated, and in many of the poor, who with difficulty support their families by incessant labour.