Secondly, there are new parts or new vessels produced in many diseases, as on the cornea of the eye in ophthalmy, in wens and cancers, which cannot be supposed to have had a prototype or original miniature in the embryon.

Thirdly, how could mule-animals be produced, which partake of the forms of both the parents, if the original embryon was a miniature existing in the semen of the male parent? if an embryon of the male ass was only expanded, no resemblance to the mare could exist in the mule.

This mistaken idea of the extension of parts seems to have had its rise from the mature man resembling the general form of the fetus; and from thence it was believed, that the parts of the fetus were distended into the man; whereas they have increased 100 times in weight, as well as 100 times in size; now no one will call the additional 99 parts a distention of the original one part in respect to weight. Thus the uterus during pregnancy is greatly enlarged in thickness and solidity as well as in capacity, and hence must have acquired this additional size by accretion of new parts, not by an extension of the old ones; the familiar act of blowing up the bladder of an animal recently slaughtered has led our imaginations to apply this idea of distention to the increase of size from natural growth; which however must be owing to the apposition of new parts; as it is evinced from the increase of weight along with the increase of dimension; and is even visible to our eyes in the elongation of our hair from the colour of its ends; or when it has been dyed on the head; and in the growth of our nails from the specks sometimes observable on them; and in the increase of the white crescent at their roots, and in the growth of new flesh in wounds, which consists of new nerves as well as of new blood-vessels.

[3]. Lastly, Mr. Buffon has with great ingenuity imagined the existence of certain organic particles, which are supposed to be partly alive, and partly mechanic springs. The latter of these were discovered by Mr. Needham in the milt or male organ of a species of cuttle fish, called calmar; the former, or living animalcula, are found in both male and female secretions, in the infusions of seeds, as of pepper, in the jelly of roasted veal, and in all other animal and vegetable substances. These organic particles he supposes to exist in the spermatic fluids of both sexes, and that they are derived thither from every part of the body, and must therefore resemble, as he supposes, the parts from whence they are derived. These organic particles he believes to be in constant activity, till they become mixed in the womb, and then they instantly join and produce an embryon or fetus similar to the two parents.

Many objections might be adduced to this fanciful theory, I shall only mention two. First, that it is analogous to no known animal laws. And secondly, that as these fluids, replete with organic particles derived both from the male and female organs, are supposed to be similar; there is no reason why the mother should not produce a female embryon without the assistance of the male, and realize the lucina sine concubitu.

[IV]. [1]. I conceive the primordium, or rudiment of the embryon, as secreted from the blood of the parent, to consist of a simple living filament as a muscular fibre; which I suppose to be an extremity of a nerve of loco-motion, as a fibre of the retina is an extremity of a nerve of sensation; as for instance one of the fibrils, which compose the mouth of an absorbent vessel; I suppose this living filament, of whatever form it may be, whether sphere, cube, or cylinder, to be endued with the capability of being excited into action by certain kinds of stimulus. By the stimulus of the surrounding fluid, in which it is received from the male, it may bend into a ring; and thus form the beginning of a tube. Such moving filaments, and such rings, are described by those, who have attended to microscopic animalcula. This living ring may now embrace or absorb a nutritive particle of the fluid, in which it swims; and by drawing it into its pores, or joining it by compression to its extremities, may increase its own length or crassitude; and by degrees the living ring may become a living tube.

[2]. With this new organization, or accretion of parts, new kinds of irritability may commence; for so long as there was but one living organ, it could only be supposed to possess irritability; since sensibility may be conceived to be an extension of the effect of irritability over the rest of the system. These new kinds of irritability and of sensibility in consequence of new organization, appear from variety of facts in the more mature animal; thus the formation of the testes, and consequent secretion of the semen, occasion the passion of lust; the lungs must be previously formed before their exertions to obtain fresh air can exist; the throat or œsophagus must be formed previous to the sensation or appetites of hunger and thirst; one of which seems to reside at the upper end, and the other at the lower end of that canal.

Thus also the glans penis, when it is distended with blood, acquires a new sensibility, and a new appetency. The same occurs to the nipples of the breasts of female animals, when they are distended with blood, they acquire the new appetency of giving milk. So inflamed tendons and membranes, and even bones, acquire new sensations; and the parts of mutilated animals, as of wounded snails, and polypi, and crabs, are reproduced; and at the same time acquire sensations adapted to their situations. Thus when the head of a snail is reproduced after decollation with a sharp rasor, those curious telescopic eyes are also reproduced, and acquire their sensibility to light, as well as their adapted muscles for retraction on the approach of injury.

With every new change, therefore, of organic form, or addition of organic parts, I suppose a new kind of irritability or of sensibility to be produced; such varieties of irritability or of sensibility exist in our adult state in the glands; every one of which is furnished with an irritability, or a taste, or appetency, and a consequent mode of action peculiar to itself.

In this manner I conceive the vessels of the jaws to produce those of the teeth, those of the fingers to produce the nails, those of the skin to produce the hair; in the same manner as afterwards about the age of puberty the beard and other great changes in the form of the body, and disposition of the mind, are produced in consequence of the new secretion of semen; for if the animal is deprived of this secretion those changes do not take place. These changes I conceive to be formed not by elongation or distention of primeval stamina, but by apposition of parts; as the mature crab-fish, when deprived of a limb, in a certain space of time has power to regenerate it; and the tadpole puts forth its feet long after its exclusion from the spawn; and the caterpillar in changing into a butterfly acquires a new form, with new powers, new sensations, and new desires.