In Lancashire negotiations were opened through the medium of Roger Nowell of Read, a royalist captain, but a relative of Colonel Shuttleworth, and it was decided to attempt a meeting of a certain number from each party at Blackburn on Thursday, October 13. Shuttleworth wrote to Holland and Egerton in Manchester asking for their co-operation, and they replied on October 10 agreeing to the meeting, but suggesting Bolton as a better place since they were not willing to leave their own Hundred. Shuttleworth replied next day to Nowell naming Bolton as the place, and offering either the following Monday or Tuesday, October 17 or 18 for the date. Nowell fixed October 18 with William Farington, and it was arranged that six leaders from each side should meet. The Parliamentarians were Shuttleworth, Starkie, Egerton, Holland, John Bradshaw and John Braddyl; the royalists Farington, Alexander Rigby of Burgh, John Fleetwood, Savile Radcliffe, and it was hoped Sir Thomas Barton and Robert Holt of Castleton. But the intended meeting never took place. Parliament somehow had news of the arrangement, and promptly put their veto upon it. On October 15 Holland wrote from Manchester that Parliament had forbidden any local attempts at pacification; Shuttleworth forwarded the letter to the royalists, and the incident closed.[73]

There seems to have been one further attempt to bring about a pacification in Lancashire, or perhaps it would be more correct to say that Manchester was included in negotiations which were proceeding in Cheshire at the initiative of Lord Kilmorey and Lord Brereton. It was proposed that the troops in and near Manchester should be disbanded and the town 'secured' by the Earl of Derby. But the Parliamentarians had nothing to gain by the terms suggested, and the former failure had made them more cautious. They replied that they had done nothing consciously to provoke Lord Derby's hostility; but that if satisfactory proposals for pacification were submitted they would send them up to Parliament immediately by a special messenger.[74] Meanwhile the royalists in the county were also arming, and in spite of peace proposals all preparations were being made for a protracted struggle. After retreating a little way from Manchester Lord Derby seems to have sent some regiments to the King and made his own headquarters at Warrington. But he was reported to be in a very despondent frame of mind, "for the last Thursday (November 24) at Warrington at dinner he said he was born under an unfortunate planet and that he thought some evil constellation reigned at the time of his birth, with many such other words of passion and discontent." There was even a report about this time that his life was in danger, which is the more credible as it comes from a royalist source. He summoned a meeting of his supporters on October 10 at Warrington,[75] and it was resolved to call out the trained bands and freehold bands of Lancashire and to raise horse, and also to bring about an association with the counties of Shropshire, Flint, Denbigh, Cumberland and Westmorland. The resolutions were signed by Derby and 23 others; it is rather surprising to find that the Parliamentarian leaders were also summoned to this meeting.[76] Shuttleworth and Starkie certainly had invitations, and probably some others also. The chief royalist garrisons were established at Warrington, Wigan and Preston. Wigan was the nearest town to Lathom House, and was described by its opponents as the "most malignant town in all the county"; Warrington, however, on account of its geographical importance as commanding the only bridge into Cheshire, was the most strongly fortified, and contained the most numerous garrison. At the end of October the Parliamentarian leaders had information that there were royalist troops to the number of 1400 in six garrisons, of which 400 were at Warrington, 300 at Preston and 200 at Wigan.[77] In December another royalist meeting was held at Preston and the organisation was further completed. Collectors were appointed for every Hundred to raise the sum of £8,700 to be employed for the payment of 2000 foot and 400 horse and for the provision of a magazine. The collectors were Girlington and Roger Kirkby for Lonsdale Hundred; Adam Mort, Mayor of Preston, and Alexander Rigby of Burgh for Amounderness; Farington and John Fleetwood for Leyland; Henry Ogle, John Bretherton and Robert Mercer for West Derby; Robert Holt and Francis Sherington for Salford; and Sir John Talbot and Radcliffe Assheton for Blackburn. The rates of pay were fixed; and Girlington, Mort, Kirkby and James Anderton or any three of them were to form a standing council at Preston to give reports periodically to Lord Derby, and having power to summon other advisers as they pleased.[78]

Actual hostilities began again about the end of November, and for two months in spite of the winter, there was constant fighting in various parts of the county. The climax of the campaign, which on the whole went greatly in favour of the Parliamentarians, was their capture of Preston in February, 1642‑3. A number of skirmishes occurred almost simultaneously at the end of November, the first being in Blackburn Hundred.[79] There had been a general meeting of royalists at Preston on November 7, and a week or two later Sir Gilbert Hoghton fired his beacon as a signal to the Fylde. Hoghton Tower occupies a conspicuous position, and the light of the beacon would be seen all over the low lying country nearer the sea. With the troops thus raised he disarmed Whalley and occupied Blackburn. Colonels Shuttleworth and Starkie, hearing of this, hastily raised 8000 men and attacked the royalists by night. Moonlight prevented a complete surprise, but the victory was complete. After two hours fighting they gained an entrance into Blackburn, and the royalists fled in such haste that they left their own arms and all that they had seized in Whalley. Hoghton himself escaped with difficulty.

A few days after this engagement, on Sunday, November 27, a skirmish occurred in which Lord Derby's troops were concerned, though it does not appear that he himself was present. The countryside was going to church when a post rode in with the news that the Earl's troops were marching towards Chowbent; about 3000 men were hastily collected against him and a running fight ensued all the way to Leigh, some two miles distant. The royalists were gradually driven back, some being killed and many wounded. On Lowton Common, two miles beyond Leigh, they turned and faced the Parliamentarian horse which had left the foot far behind; but after a short stand they again broke and fled, many prisoners being taken in the pursuit.[80]

It is worthy of remark that most of the actual fighting during the Civil War in Lancashire was running fighting. This first instance is only one of many more in the next few years. The decisive battle in the county covered many miles of ground, and even the battle of Preston itself was, after Langdale's first stand, a long and straggling engagement half way across the county. Attacks on houses or towns excepted, there were few if any pitched battles until that at Wigan Lane in 1651, which was the last battle of the war.

The next encounter went in favour of the royalists, and, as all the Parliamentarians admit, it was a great disaster. During the next few weeks both parties sent out from their garrisons plundering expeditions against houses in the neighbourhood which belonged to the other side. In retaliation for some plunder by the Wigan garrison, a local company of Parliamentarians together with two from Manchester, attacked the house of a Roman Catholic gentleman near Wigan. They were surprised by a superior force of royalists, but abandoning their booty they managed to escape. A day or two afterwards, however, they were again surprised near Westhoughton by a force of 1000 men, and being surrounded they were all compelled to surrender at discretion. This was on December 15, 1642; 160 men together with Captains Bradshaw and Venables were captured. Venables was probably some months in captivity at Lathom House; Bradshaw was released earlier, but soon afterwards died.[81]

This was, however, the only royalist success for some time to come. The two remaining engagements of the year went in favour of the Parliamentarians. Both took place on Christmas Eve. On that day the Manchester garrison accompanied by Rosworm marched out by way of Chowbent, which they cleared of the enemy, to Leigh. This was a measure of retaliation for plundering by the Wigan garrison in the neighbourhood. The royalists made some resistance, but being largely outnumbered by the attacking force they were surrounded and overpowered. The Parliamentarians marched on the market place from different sides, and they recovered many of the arms which had been captured a fortnight before. The victory was regarded with great satisfaction as a revenge for Venables' surrender. Within three days the Parliamentarian troops were back in Manchester. The other engagement was also fought on previously contested ground at Blackburn, in this case the assailants being the royalists. Sir Gilbert Hoghton had a special case against this garrison as it was only three miles from his own house. Accordingly on Christmas Eve he marched out of Blackburn, it was said with 5000 men, to attack the town. The garrison numbered only 400. But there was no fighting at close quarters; the royalists had with them one small piece of cannon which they discharged repeatedly without effect, but they hardly approached within musket shot at all, and under cover of night they retreated. No lives were lost and the only result was the plundering of the countryside.[82]

In January, 1642‑3, there was very little done by either side. Some Manchester troops set out to capture the house of Mr. Leigh at Adlington in Cheshire, but they returned without doing anything. The only other incident was an unsuccessful plot by Sir John Talbot, which is reported incorrectly in details though there seems to be no doubt of the main facts. Talbot was one of the royalist collectors for Blackburn Hundred and lived at Salesbury Hall near Ribchester. Early in January he invited some of the Parliamentarian leaders to pay a visit to his house; but suspecting some treachery they sent a troop of horse instead, and found that it was a plot to capture the supposed guests. Returning with reinforcements they attacked the ambush with superior numbers and sacked the house.

The next trial of strength, the capture of Preston by the Parliamentarians, was an important event. Confident in its strength and thinking no doubt that an attack was improbable, the royalists had relaxed their vigilance, and Preston was only weakly garrisoned. News of this being brought to Colonel Shuttleworth, he planned a joint attack with the Manchester garrison, which was now under the command of Sir John Seaton. Seaton left Manchester on Monday evening, February 6, accompanied by Colonel Holland, Serg.-Major Birch, Serg.-Major Sparrow, Captain Booth and other officers, with three foot companies from Manchester and three from Bolton. They came to Blackburn on Tuesday night, and were joined there by four or five companies more. These altogether numbering about 1000 men together with about 600 'club-men' set out from Blackburn late on Wednesday evening, February 8, for Preston, which is ten miles away. It was a clear night and the whole force having crossed Ribble Bridge, which was almost if not entirely undefended, drew up in the fields a little distance from the town walls. The attack was made at about half past seven o'clock, a little while before sunrise, at two places. A few men attacked from the south and the main body from the east of the town; the former being guided by somebody familiar to the ground soon gained an entrance, but elsewhere the royalists offered a most determined resistance. For two hours the garrison fought stoutly. There were outer and inner walls, and the garrison kept both with pikes and swords. Captain John Booth showed conspicuous bravery, and was the first to scale the outer defences, bidding his soldiers either follow him or give him up; in another place a small body of the Parliamentarians driven back from the outer walls gained entrance by means of a house. The Manchester troops under Holland showed great bravery. After other resistance had been overcome the royalists occupied the church tower, and were dislodged with difficulty. Then the defence collapsed, and the besiegers became masters of the town. The losses do not seem to have been very great on either side; but the royalists' killed included Adam Mort, the Mayor, and his son, both energetic supporters of the cause, Radcliffe Hoghton, brother of Sir Gilbert Hoghton, and others of note. Very few of the Parliamentarian officers were killed. There were many prisoners taken, including Lady Hoghton, Lady Girlington, Mr. Towneley, Mr. Anderton of Clayton, a son of Sir John Talbot, and a nephew of Sir Gilbert Hoghton. Sir Gilbert only saved himself by a hasty flight to Wigan.[83]

The capture of Preston was an enormous blow to the King's party in Lancashire. An account, written by John Tilsley, Vicar of Dean, describes the engagement as "much to the advancement of the public work in this county and not so altogether impertinent to the Kingdom"; and there is justification for his statement. In attacking Preston the Manchester garrison were venturing for the first time right into the enemy's country. No longer on the defensive as at the end of 1642, they were now reversing the original position of the two parties in the county. And if the royalist standard had fallen at Preston it could hardly be raised with safety anywhere in Lancashire. Preston was also important geographically, as being on the main road through Lancashire. "It blocks up the way to all the north-east part of Lancashire, where were the chief malignants and the cream of the Earl's forces."[84] Moreover Preston symbolised the royalist cause, and since it was (as it still is) a stronghold of Roman Catholicism, it was specially obnoxious to the Puritan party. The Lancashire Parliamentarians, therefore, had captured their enemy's stronghold and broken the lines of communication between Newcastle, Chester and Shrewsbury.