Weismann's view of the secondary "introduction of physiological death in the multicellulars" is just as untenable as his theory of the immortality of the unicellulars. According to this opinion, the death of the histona—both the metaphyta and metazoa—is a purposive outcome of adaptation, only introduced by selection when the multicellular organism has reached a certain stage of complexity of structure, which is incompatible with its original immortality. Natural selection would thus kill the immortal and preserve only the mortal; it would interfere with the multiplication of the immortals in the bloom of their years, and only use the mortal for rearing posterity. The curious conclusions which Weismann reached in developing this theory of death, and the striking contradictions to his own theory of the germ-plasm which he fell into, have been pointed out by Kassowitz in the forty-ninth chapter of his General Biology. In my opinion, this paradoxical theory of death has no more basis than the germ-plasm theory he has ingeniously connected with it. We may admire the subtlety and depth of the speculations with which Weismann has worked out his elaborate molecular theory. But the nearer we get to its foundations the less solid we find them. Moreover, not one of the many supporters of the theory of germ-plasm has been able to make profitable use of it in the twenty years since it was first published. On the other hand, it has had an evil influence in so far as it denied the inheriting of acquired characters, which I hold, with Lamarck and Darwin, to be one of the soundest and most indispensable supports of the theory of descent.
In discussing the question of the real causes of death, we confine our attention to normal or physiological death without considering the innumerable causes of accidental or pathological death, by illness, parasites, mishaps, etc. Normal death takes place in all organisms when the limit of the hereditary term of life is reached. This limit varies enormously in different classes of organisms. Many of the unicellular protophyta and protozoa live only a few hours, others several months or years; many one-year plants and lower animals live only a summer in our temperate climate, and only a few weeks or months in the arctic circle or on the snow-covered Alps. On the other hand, the larger vertebrates are not uncommonly a hundred years old, and many trees live for a thousand years. The normal span of life has been determined in all species in the course of their evolution by adaptation to special conditions, and has then been transmitted to offspring by heredity. In the latter, however, it is often subject to considerable modifications.
The organism has been compared, on the modern "machine theory" of life, to an artificially constructed mechanism, or an apparatus in which the human intelligence has put together various parts for the attainment of a certain end. This comparison is inapplicable to the lowest organisms, the monera, which are devoid of such a mechanical structure. In these primitive "organisms without organs" (chromacea and bacteria) the sole cause of life is the invisible chemical structure of the plasm and the metabolism effected by this. As soon as this ceases death takes place (cf. chapter ix.). In the case of all other organisms the comparison is useful in so far as the orderly co-operation of the various organs or parts accomplishes a certain task by the conversion of virtual into active force. But the great difference between the two is that in the case of the machine the regularity is due to the purposive and consciously acting will of man, whereas in the case of the organism it is produced by unconscious natural selection without any design. On the other hand, the two have another important feature in common in the limited span of life which is involved in their being used up. A locomotive, ship, telegraph, or piano, will last only a certain number of years. All their parts are worn out by long use, and, in spite of all repairing, become at last useless. So in the case of all organisms, the various parts are sooner or later worn out and rendered useless; this is equally true of the organella of the protist and the organs of the histon. It is true that the parts may be repaired or regenerated; but sooner or later they cease to be of service, and become the cause of death.
When we take the idea of regeneration, or the recuperation of parts that have been rendered useless, in the widest sense, we find it to be a universal vital function of the greatest importance. The whole metabolism of the living organism consists in the assimilation of plasm, or the replacing of the plasma-particles which are constantly used up by dissimilation (cf. chapter x.). Verworn has given the name of biogens to the hypothetical molecules of living matter—which I regard with Hering as endowed with memory, and (1875) have called plastidules. He says: "The biogens are the real vehicles of life. In their constant decay and reconstruction consists the process of life, which expresses itself in the great variety of vital phenomena." The relation of assimilation (the building-up of the biogens) to dissimilation (the decay of the biogens) may be expressed by a fraction to which the name biotonus is given A/D. It is of radical importance in the various phenomena of life. The variations in the size of this fraction are the cause of all change in the life-expression of every organism. When the biotone increases, and the metabolism quotient becomes more than one, we have growth; when, on the other hand, it falls below one, and the biotone decreases, we have atrophy, and finally death. New biogens are constructed in regeneration. In generation or reproduction groups of biogens (as germ-plasm) are released from the parent in consequence of redundant growth, and form the foundation of new individuals.
The phenomena of regeneration are extremely varied, and have of late years been made the subject of a good deal of comprehensive experiment, especially on the side of what is called "mechanical embryology." Many of these experimental embryologists have drawn far-reaching conclusions from their somewhat narrow experiments, and have partly urged them as objections to Darwinism. They imagine that they have disproved the theory of selection. Most of these efforts betray a notable lack of general physiological and morphological knowledge. As they also generally ignore the biogenetic law, and take no account of the fundamental correlation of embryology and stem history, we can hardly wonder that they reach the most absurd and contradictory conclusions. Many examples of this will be found in the Archiv für Entwickelungsmechanik. When, however, we make a comprehensive survey of the interesting field of regeneration processes, we discover a continuous series of development from the simplest repair of plasm in the unicellular protists to the sexual generation of the higher histona. The sperm-cells and ova of the latter are redundant growth-products, which have the power of regenerating the whole multicellular organism. But many of the higher histona have also the capacity to produce new individuals by regeneration from detached pieces of tissue, or even single cells. In the peculiar mode of metabolism and growth which accompanies these processes of regeneration, the memory of the plastidule, or the unconscious retentive power of the biogens, plays the chief part (cf. my Perigenesis of the Plastidule, 1875). In the most primitive kinds of the unicellular protists we find the phenomena of death and regeneration in the simplest form. When an unnucleated moneron (a chromaceum or bacterium) divides into two equal halves, the existence of the dividing individual comes to an end. Each half regenerates itself in the simplest conceivable way by assimilation and growth, until it, in turn, reaches the size of the parent organism. In the nucleated cells of most of the protophyta and protozoa it is more complicated, as the nucleus becomes active as the central organ and regulator of the metabolism. If an infusorium is cut into two pieces, only one of which contains the nucleus, this one alone grows into a complete nucleated cell; the unnucleated portion dies, being unable to regenerate itself.
In the multicellular body of the tissue-forming organisms we must distinguish between the partial death of the various cells and the total death of the whole organism, or cell-state, which they make up. In many of the lower tissue-plants and tissue-animals the communal link is very loose and the centralization slight. Odd cells or groups of cells may be set loose, without any danger to the life of the whole histon, and grow into new individuals. In many of the algæ and liverworts (even in the bryophyllum, closely related to the stone-crop, or sedum)—as well as in the common fresh-water polyp, hydra, and other polyps—every bit that is cut off is capable of growing into a complete individual. But the higher the organization is developed and the closer the correlation of the parts and their co-operation in the life of the centralized stock or person, the slighter we find the regenerative faculty of the several organs. Even then, however, many used-up cells may be removed and replaced by regenerated new cells. In our own human organism, as in that of the higher animals, thousands of cells die every day, and are replaced by new cells of the same kind, as, for instance, epidermic cells at the surface of the skin, the cells of the salivary glands or the mucous lining of the stomach, the blood-cells, and so on. On the other hand, there are tissues that have little or nothing of this repairing power, such as many of the nerve-cells, sense-cells, muscle-cells, etc. In these cases a number of constant cell-individuals remain with their nucleus throughout life, although a used-up portion of their cell-body may be replaced by regeneration from the cytoplasm. Thus our human body, like that of all the higher animals and plants, is a "cell-state" in another sense. Every day, nay, every hour, thousands of its citizens, the tissue-cells, pass away, and are replaced by others that have arisen by cleavage of similar cells. Nevertheless, this uninterrupted change of our personality is never complete or general. There is always a solid groundwork of conservative cells, the descendants of which secure the further regeneration.
Most organisms meet their death through external or accidental causes—lack of sufficient food, isolation from their necessary environment, parasites and other enemies, accidents and disease. The few individuals who escape these accidental causes of death find the end of life in old age or senility, by the gradual decay of the organs and dwindling of their functions. The cause of this senility and the ensuing natural death is determined for each species of organisms by the specific nature of their plasm. As Kassowitz has lately pointed out, the senility of individuals consists in the inevitable increase in the decay of protoplasm and the metaplastic parts of the body which this produces. Each metaplasm in the body favors the inactive break-up of protoplasm, and so also the formation of new metaplasms. The death of the cells follows, because the chemical energy of the plasm gradually falls off from a certain height, the acme, of life. The plasm loses more and more the power to replace by regeneration the losses it sustains by the vital functions. As, in the mental life, the receptivity of the brain and the acuteness of the senses gradually decay, so the muscles lose their energy, the bones become fragile, the skin dry and withered, the elasticity and endurance of the movements decrease. All these normal processes of senile decay are caused by chemical changes in the plasm, in which dissimilation gains constantly on assimilation. In the end they inevitably lead to normal death.
While the gradual decay of the bodily forces and the senile degeneration of the organs must necessarily cause the death of the soundest organism in the end, the great majority of men pass away through illness long before this normal term of life is reached. The external causes of this are the attacks of enemies and parasites, accidents, and unfavorable conditions of life. These cause changes in the tissues and their component cells, which first occasion the partial death of particular sections, and then the total death of the whole individual. The modifications of the living matter which produce disease and premature death are called necrobioses. They consist partly of histolyses—that is to say, degeneration of the cells by atrophy, dissolution, withering (mortification), or colliquation; and partly of metaplasmosisms, or metamorphoses of the plasm—fatty, mucous, chalky, or amyloid metamorphoses of the cells. It was the great merit of Rudolph Virchow that he proved, in his epoch-making Cellular Pathology (1858), that all diseases in man and other organisms may be reduced to such modifications of the cells which make up the tissues. Hence disease, with its pain, is a physiological process, a life under injurious and dangerous conditions. As in all normal vital phenomena, so in abnormal or pathological, the ultimate ground must be sought in the physical and chemical processes in the plasm. Pathology is a part of physiology. This discovery has cut the ground from under the older notion of disease as a special entity, a devil, or a divine punishment.
The natural physical explanation of death, which has been made possible by modern physiology and pathology, has shattered, not only all the old superstitious ideas about disease and death, but also a number of important metaphysical dogmas which built upon them. Such was, for instance, the naïve belief in a conscious Providence, controlling the fate of individuals and determining their death. I do not fail to appreciate the great subjective value which such a trust in a protecting Providence has for men amid their countless dangers. We may envy the childish temper for the confidence and hope which it derives from this belief. But as we do not seek to have our emotions gratified by poetic fictions, we are bound to point out that reason cannot detect the shadow of a proof of the existence and action of this conscious Providence, or "loving Father in heaven." We read daily in our journals of accidents and crimes of all kinds that cause the unexpected death of happy human beings. Every year we read with horror the statistics of the thousands of deaths from shipwreck and railway accidents, earthquakes and landslips, wars and epidemics. And then we are asked to believe in a loving Providence that has decreed the death of each of these poor mortals! We are asked to console ourselves in face of the tragedy with the hollow phrases: "God's will be done," or "God's ways are wonderful." Simple children and dull believers may soothe themselves with such phrases. They no longer impose on educated people in the twentieth century, who prefer a full and fearless knowledge of the truth.
When our monistic and rational conception of death is described as dreary and hopeless, we may answer that the prevalent dualistic view is merely an outcome of hereditary habits of thought and mystic training in early youth. When these are displaced by progressive culture and science, it will be clear that man has lost nothing, but gained much, as regards his life on earth. Convinced that there is no eternal life awaiting him, he will strive all the more to brighten his life on earth and rationally improve his condition in harmony with that of his fellows. If it is objected that then everything will depend on mere "chance," instead of being controlled by a conscious Providence or a moral order of the world, I must refer the reader for my reply to the close of the fourteenth chapter of the Riddle, where I have dealt with fate, providence, end, aim, and chance. And if it is further claimed that our realistic view of life leads to pessimism, there is no better ground for such an accusation.