The problem as to why the stomach does not digest itself has puzzled scientists for many years. Investigations of the twentieth century have at last solved this fascinating question. The walls of the human stomach are composed of proteid material, and should be dissolved by the gastric juice according to all known chemical laws. The explanation formerly given was that the stomach did not digest itself because it was alive. This answer did not satisfy scientists.
Antipepsin in the blood
There has recently been discovered an enzym, known as antipepsin, which is secreted by the cells in the stomach-walls. This antipepsin destroys the action of the pepsin, thus in turn preventing its action on the stomach-wall itself. Were antipepsin secreted in sufficiently large quantities to mix with the food in the stomach-cavity, no digestion could take place. The presence of this antipepsin in the stomach-walls has been proved in the following manner: The arteries leading to a portion of the stomach-wall of a dog was severed. This portion, receiving no blood supply, did not form the usual amount of antipepsin. The secretion of pepsin went on in the remainder of the animal's stomach, but digested that portion of the stomach-wall which was receiving no blood supply; that is, secreting no antipepsin.
BILE
Function of bile
The bile is a juice secreted by the liver and is alkaline in character. It is collected by the biliary ducts to be conveyed into the duodenum. The most important constituents of bile are bile salts and sodium glycocholate. The chief purposes of bile are to emulsify fats, thus aiding them to pass through the intestinal walls, and to stimulate intestinal peristalsis.
PANCREATIC JUICE
Function of the pancreas
The pancreas is a secretive gland located entirely outside of the intestinal walls, and produces a juice which is poured into the small intestines at the point where the bile enters. Pancreatic juice is acidulous, and also strongly alkaline. As soon as the food, passing from the stomach, comes in contact with the pancreatic juice and the bile, the acid is neutralized, and the mass becomes alkaline.
The pancreatic juice contains three important enzyms: