It may have been on the death of Sancia that Rodrigo was placed under the protection of another aunt, Isabella d'Aragona, his father's eldest sister, the most unfortunate woman of the age, wife of Giangaleazzo of Milan, who had been poisoned by Ludovico il Moro. The figure of Isabella of Milan is the most tragic in the history of Italy of the period beginning with the invasion of Charles VIII—an epoch filled with a series of disasters that involved every dynasty of the country. For she was affected at one and the same time by the fall of two great houses, that of Sforza and that of Aragon. The saying of Caracciolo in his work, De varietate fortunæ, regarding the Sforza, namely, that there is no tragedy however terrible for which this house would not furnish an abundance of material may well be applied to both these families. Isabella had beheld the fall of her once mighty house, and she had seen her own son Francesco seized and taken to France by Louis XII, where he died, a priest, in his early manhood. She herself had retired to Bari, a city which Ludovico il Moro had given up to her in 1499, and of which she remained duchess until her death, February 11, 1524.

Donna Isabella had taken Lucretia's son to herself, and from the records of the household expenses of the Duchess of Ferrara it appears that he was with her in Bari in March, 1505, for on the twenty-sixth of that month there is the following entry: "A suit of damask and brocade which her Majesty sent her son Don Rodrigo in Bari as a present."[224] April 3d his mother sent his tutor, Baldassare Bonfiglio, who had come to Naples, back to him. This man is named in the register under date of February 25, 1506, as tutor of Don Giovanni. It appears, therefore, that this child also was in Bari, and was being educated with his playfellow Rodrigo. In October, 1506, we find the little Giovanni in Carpi, where he was probably placed at the court of the Pio. From there Lucretia had him brought to the court of Ferrara on the date mentioned. She therefore was allowed to have this mysterious infante, but not her own child Rodrigo, with her. In November, 1506, Giovanni must again have been in Carpi, for Lucretia sent him some fine linen apparel to that place.[225]

Both children were together again in Bari in April, 1508, for in the record of the household expenses the expenditures for both, beginning with May of that year, are given together, and a certain Don Bartolommeo Grotto is mentioned as instructor to both.[226] The son of Lucretia and of the murdered Alfonso, therefore, died in the home of Donna Isabella in Bari, which was not far from his hereditary duchy of Biselli.

We have a letter written by this unhappy Princess Isabella a few weeks after the death of the youthful Rodrigo, to Perot Castellar, Governor of Biselli:

Monsignor Perot: We write this merely to ask you to compel those of Corato to pay us what they have to pay, from the revenue of the illustrious Duke of Biselli, our nephew of blessed memory, for shortly a bill will come from the illustrious Duchess of Ferrara, and in case the money is not ready we might be caused great inconvenience. Those of Corato may delay, and we might be compelled to find the money at once. Therefore you must see to it that we are not subjected to any further inconvenience, and that we are paid immediately; for by so doing you will oblige us, and we offer ourselves to your service.

Isabella of Aragon, Duchess of Milan, alone in misfortune.[227]

Bari, October 14, 1592.

Rodrigo's[228] mother laid claim to the property he left, which, as is shown by certain documents, she recovered from Isabella d'Aragona as guardian of the deceased, to the amount of several thousand ducats. To do this she was forced to engage in a long suit, and as late as March, 1518, she sent her agent, Giacomo Naselli, to Rome and Naples regarding it. His report to Cardinal Ippolito is still in existence.

Whatever were the circumstances which had compelled Lucretia to send her son away, on whom, as we have shown, she always lavished her maternal care, the unfortunate child's experience will always be a blot on her memory.