Shortly after this, April 23d, Cardinal della Rovere slipped away from Ostia and into France to urge Charles VIII to invade Italy, not to attack Naples, but to bring this simoniacal pope before a council and depose him.

At the beginning of July Ascanio Sforza, now openly at strife with Alexander, also left the city. He went to Genazzano and joined the Colonna, who were in the pay of France. Charles VIII was already preparing to invade Italy. The Pope and King Alfonso met at Vicovaro near Tivoli, July 14th.

In the meantime important changes had taken place in Lucretia's palace. Her husband had hurriedly left Rome, as he could do as a captain of the Church, in which capacity he had to join the Neapolitan army, now being formed in Romagna under the command of the Duke Ferrante of Calabria. By his nuptial contract he was bound to take his bride with him to Pesaro. She was accompanied by her mother, Vannozza, Giulia Farnese, and Madonna Adriana. Alexander himself, through fear of the plague, which had appeared, commanded them to depart. The Mantuan ambassador in Rome reported this to the Marchese Gonzaga, May 6th, and also wrote him on the fifteenth as follows: "The illustrious Lord Giovanni will certainly set out Monday or Tuesday accompanied by all three ladies, who, by the Pope's order, will remain in Pesaro until August, when they will return."[32]

Sforza's departure must have taken place early in June, for on the eleventh of that month a letter from Ascanio was sent to his brother in Milan informing him that the lord of Pesaro with his wife and Madonna Giulia, the Pope's mistress, together with the mother of the Duke of Gandia, and Giuffrè, had set out from Rome for Pesaro, and that his Holiness had begged Madonna Giulia to come back soon.[33]

Alexander had returned to Rome from Vicovaro, July 18th, and on the 24th he wrote his daughter the following letter:

Alexander VI, Pope; by his own hand.

Donna Lucretia, Dearest Daughter: For several days we have had no letter from you. Your neglect to write us often and tell us how you and Don Giovanni, our beloved son, are, causes us great surprise. In future be more heedful and more diligent. Madonna Adriana and Giulia have reached Capodimonte, where they found the latter's brother dead. His death caused the cardinal and Giulia such distress that both fell sick of the fever. We have sent Pietro Caranza to look after them, and have provided physicians and everything necessary. We pray to God and the glorious Madonna that they will soon be restored. Of a truth Don Giovanni and yourself have displayed very little thought for me in this departure of Madonna Adriana and Giulia, since you allowed them to leave without our permission; for you should have remembered—it was your duty—that such a sudden departure without our knowledge would cause us the greatest displeasure. And if you say that they did so because Cardinal Farnese commanded it, you ought to have asked yourself whether it would please the Pope. However, it is done; but another time we will be more careful, and will look about to see where our interest lies. We are, thanks to God and the glorious Virgin, very well. We have had an interview with the illustrious King Alfonso, who showed us no less love and obedience than he would have shown had he been our own son. I cannot tell you with what satisfaction and contentment we took leave of each other. You may be certain that his Majesty stands ready to place his own person and every thing he has in the world at our service.

We hope that all differences and quarrels in regard to the Colonna will be completely laid aside in three or four days. At present I have nothing more to say than to warn you to be careful of your health and constantly to pray to the Madonna. Given in Rome in S. Peter's, July 24, 1494.[34]

This letter is the first of the few extant written by Alexander to his daughter. His reproof was due to the sudden departure of his mistress—contrary to his original instructions—from Pesaro before August. From there Giulia went to Capodimonte to look after her sick brother Angiolo. According to a Venetian letter written by Marino Sanuto, she had left Rome chiefly for the purpose of attending the wedding of one of her kinsmen, and the writer describes her in this place as "the Pope's favorite, a young woman of great beauty and understanding, gracious and gentle."

Alexander's letter shows us that his mistress remained in communication with him after her departure from Rome.