The war against the Orsini ended with the ignominious defeat of the papal forces at Soriano, January 23, 1497, whence Don Giovanni, wounded, fled to Rome, and where Guidobaldo was taken prisoner. The victors immediately forced a peace on most advantageous terms.

Not until the conclusion of the war did Lucretia's husband return to Rome. We shall see him again there, for the last time, at the Easter festivities of 1497, when, as Alexander's son-in-law, he assumed his official place during the celebration in S. Peter's, and, standing near Cæsar and Gandia, received the Easter palm from the Pope's hand. His position in the Vatican had, however, become untenable; Alexander was anxious to dissolve his marriage with Lucretia. Sforza was asked to give her up of his own free will, and, when he refused, was threatened with extreme measures.

Flight alone saved him from the dagger or poison of his brothers-in-law. According to statements of the chroniclers of Pesaro, it was Lucretia herself who helped her husband to flee and thus caused the suspicion that she was also a participant in the conspiracy. It is related that, one evening when Jacomino, Lord Giovanni's chamberlain, was in Madonna's room, her brother Cæsar entered, and on her command the chamberlain concealed himself behind a screen. Cæsar talked freely with his sister, and among other things said that the order had been given to kill Sforza. When he had departed, Lucretia said to Jacomino: "Did you hear what was said? Go and tell him." This the chamberlain immediately did, and Giovanni Sforza threw himself on a Turkish horse and rode in twenty-four hours to Pesaro, where the beast dropped dead.[50]

According to letters of the Venetian envoy in Rome, Sforza fled in March, in Holy Week. Under some pretext he went to the Church of S. Onofrio, where he found the horse waiting for him.[51]

The request for the divorce was probably not made by Lucretia, but by her father and brothers, who wished her to be free to enter into a marriage which would advance their plans. We are ignorant of what was now taking place in the Vatican, and we do not know that Lucretia made any resistance; but if she did, it certainly was not of long duration, for she does not appear to have loved her husband. Pesaro's escape did not please the Borgias. They would have preferred to have silenced this man forever; but now that he had gotten away and raised an objection, it would be necessary to dissolve the marriage by process of law, which would cause a great scandal.

Shortly after Sforza's flight a terrible tragedy occurred in the house of Borgia—the mysterious murder of the Duke of Gandia. On the failure of Alexander's scheme to confiscate the estates of the Orsini and bestow them on his dearly beloved son, he thought to provide for him in another manner. He made him Duke of Benevento, thereby hoping to prepare the way for him to reach the throne of Naples. A few days later, June 14th, Vannozza invited him and Cæsar, together with a few of their kinsmen, to a supper in her vineyard near S. Pietro in Vinculo. Don Giovanni, returning from this family feast, disappeared in the night, without leaving a trace, and three days later the body of the murdered man was found in the Tiber.

According to the general opinion of the day, which in all probability was correct, Cæsar was the murderer of his brother. From the moment Alexander VI knew this crime had been committed, and assumed responsibility for its motives and consequences, and pardoned the murderer, he became morally accessory after the fact, and fell himself under the power of his terrible son. From that time on, every act of his was intended to further Cæsar's fiendish ambition.

None of the records of the day say that Don Giovanni's consort was in Rome when this tragedy occurred. We are therefore forced to assume that she was not there when her husband was murdered. It is much more likely that she had not left Spain, and that she was living with her two little children in Gandia or Valencia, where she received the dreadful news in a letter written by Alexander to his sister Doña Beatrice Boria y Arenos. This is rendered probable by the court records of Valencia. September 27, 1497, Doña Maria Enriquez appeared before the tribunal of the governor of the kingdom of Valencia, Don Luis de Cabaineles, and claimed the estate, including the duchy of Gandia and the Neapolitan fiefs of Suessa, Teano, Carinola, and Montefoscolo, for Don Giovanni's eldest son, a child of three years. The duke's death was proved by legal documents, among which was this letter written by Alexander, and the tribunal accordingly recognized Gandia's son as his legal heir.[52]

Doña Maria also claimed her husband's personal property in his house in Rome, which was valued at thirty thousand ducats, and which on the death of Don Giovanni, had been transferred by Alexander VI, to the fratricide Cæsar to administer for his nephew, as appears from an official document of the Roman notary Beneimbene, dated December 19, 1498.