The moving principle in the Vatican was the measureless ambition of Cæsar, who was consuming with impatience to become a ruling sovereign. August 13, 1498, he flung aside the cardinal's robes and prepared to set out for France; Louis XII, who in April had succeeded Charles VIII, having promised him the title of Duke of Valentinois and the hand of a French princess. Alexander provided for his son's retinue with regal extravagance.

It happened one day that a train of mules laden with silks and cloth of gold on the way to Cæsar in Rome was plundered by the people of Cardinal Farnese and of his cousin Pier Paolo in the forest of Bolsena, whereupon the Pope addressed some vigorous communications to the cardinal, in whose territory, he stated, the robbery had been committed.[61]

In the service of the Farnese were numerous Corsicans, some as mercenaries and bullies, some as field laborers, and these people, who were universally feared, probably were the guilty ones, for it is difficult to believe that Cardinal Alessandro would have undertaken such a venture on his own account. It seems, however, that the relations of the Borgias and the Farnese were somewhat strained during this period. The cardinal spent most of his time on his family estates, and at this juncture little was heard of his sister Giulia. It is not even known whether or not she was living in Rome and continuing her relations with the Pope, although, from subsequent revelations, it appears that she was. April 2, 1499, we find the cardinal and his sister again in Rome, where a nuptial contract was concluded in the Farnese palace between Laura Orsini, Giulia's seven-year-old daughter, and Federico Farnese, the twelve-year-old son of the deceased condottiere Raimondo Farnese, a nephew of Pier Paolo. Laura's putative father, Orsino Orsini, was present at the ceremony.[62]

It was probably Adriana and Giulia who were endeavoring to bring about a reconciliation between the house of Orsini and the Borgias. In the spring of 1498 these barons, having issued victorious from their war with the Pope, began a bitter contest with their hereditary foes, the Colonna, which, however, ended in their own defeat. These houses made peace with each other in July, a fact which caused Alexander no little anxiety, for upon the hostility of these, the two mightiest families of Rome, depended the Pope's dominion over the city; his greatest danger lay in their mutual friendship. He therefore endeavored again to set them at loggerheads, and he succeeded in attaching the Orsini to himself,—which they subsequently had reason to regret. He accomplished his purpose so well that they intermarried with the Borgias; Paolo Orsini, Giambattista's brother, uniting his son Fabio with Girolama, a sister of Cardinal Giovanni Borgia the younger, September 8, 1498. The marriage contract was concluded in the presence of the Pope and a brilliant gathering in the Vatican, and one of the official witnesses was Don Alfonso of Biselli, who held the sword over the young couple.[63]

Shortly afterwards, October first, Cæsar Borgia set sail for France, where he was made Duke of Valentinois, and where, in May, 1499, he married Charlotte d'Albret, sister of the King of Navarre. At this court he met two men who were destined later to exercise great influence upon his career—George of Amboise, Archbishop of Rouen, to whom he had brought the cardinal's hat, and Giuliano della Rovere. The latter, hitherto Alexander's bitterest enemy, now suffered himself, by the intermediation of the King of France, to be won over to the cause of the Borgias; he permitted himself even to become Cæsar's stepping-stone to greatness.

The reconciliation was sealed by a marriage between the two families; the city prefect, Giovanni della Rovere, Giuliano's brother, betrothing his eighteen-year-old son Francesco Maria to Angela Borgia, September 2, 1500.

Angela's father, Giuffrè, was a son of Giovanni, sister of Alexander VI, and of Guglielmo Lanzol. Giovanni Borgia the younger, Cardinal Ludovico, and Rodrigo, captain of the papal guard, were her brothers. Her sister Girolama, as above stated, was married to Fabio Orsini. The ceremony of Angela's betrothal took place in the Vatican in the presence of the ambassador of France.

For the purpose of driving Ludovico il Moro from Milan, Louis XII had concluded an alliance with Venice, which the Pope also joined on the condition that France would help his son to acquire Romagna.

Ascanio Sforza, who was unable to prevent the loss of Milan, and who knew that his own life was in danger in Rome, fled July 13, 1499, to Genazzano and subsequently to Genoa.

His example was followed by Lucretia's youthful consort. We do not know what occurred in the Vatican to cause Don Alfonso quietly to leave Rome, where he had spent but a single year with Lucretia. We can only say that his decision must have been brought about by some turn which the Pope's politics had taken. The object of the expedition of Louis XII was not only the overthrow of the Sforza dynasty in Milan, but also the seizure of Naples; it was intended to be a sequel to the attempt of Charles VIII, which was defeated by the great League. The young prince was aware of the Pope's intention to destroy his uncle Federico, who had deeply offended him by refusing to grant Cæsar the hand of his daughter Carlotta. After this occurrence the relations of Lucretia's husband with the Pope had altogether changed.