Doctor Holmes's humor permeates every sentence that he wrote. Even in his most serious moods we meet with it in a peculiar phrase, or the use of some exceptional word.

Now and then his wit is very brilliant, lighting up its surroundings like the sudden appearance of a meteor. The essence of humor consists in a contrast which places the object or person compared at a disadvantage. If the contrast is a dignified one we have high comedy; but if the reverse, low comedy. Some of Holmes's comparisons make the reader laugh out aloud. He says that a tedious preacher or lecturer, with an alert listener in the audience, resembles a crow followed by a king-bird,—a spectacle which of itself is enough to make one smile; and as for an elevated comparison, what could be more so, unless we were to seek one in the moon. There is a threefold wit in it; but the full force of this can only be appreciated in the original text.

Nature commonly sets her own stamp on the face of a humorist. The long pointed nose of Cervantes is indicative of immeasurable fun, and there have been many similar noses on the faces of less distinguished wits. Doctor Holmes ridiculed phrenology as an attempt to estimate the money in a safe by the knobs on the outside, but he evidently was a believer in physiognomy, and he exemplified this in his own case. His face had a comical expression from boyhood; its profile reminded one of those prehistoric images which Di Cesnola brought from Cyprus. As if he were conscious of this he asserted his dignity in a more decided manner than a man usually does who is confident of the respect of those about him. Thus he acquired a style of his own, different from that of any other person in Boston. He was not a man to be treated with disrespect or undue familiarity.

A medical student named Holyoke once had occasion to call on him, and as soon as he had introduced himself Doctor Holmes said: "There, me friend, stand there and let me take an observation of you." He then fetched an old book from his library which contained a portrait of Holyoke's grandfather, who had also been a physician. He compared the two faces, saying: "Forehead much the same; nose not so full; mouth rather more feminine; chin not quite so strong; but on the whole a very good likeness, and I have no doubt you will make an excellent doctor." After Holyoke had explained his business Doctor Holmes finally said: "I liked your grandfather, and shall always be glad to see you here."

Oliver Wendell Holmes, Jr., was class poet of 1861, an honor which pleased his father very much. Immediately after graduating he went to the war, and came near losing his life at the battle of Antietam. A rifle- ball passed through both lungs, and narrowly missed his heart. Alexander Hamilton died of exactly such a wound in seven hours; and yet in three days Captain Holmes was able to write to his father. The Doctor started at once for the seat of war, and met with quite a series of small adventures which he afterwards described in a felicitous article in the Atlantic, called "My Hunt after the Captain." His friend, Dr. Henry P. Bowditch, lost his son in the same battle, and when they met at the railway depot Holmes said: "I would give my house to have your fortune like mine."

In a letter to Motley dated February 3, 1862, he says:

"I was at a dinner at Parker's the other day where Governor Andrew and Emerson, and various unknown dingy-linened friends of progress met to hear Mr. Conway, the not unfamous Unitarian minister of Washington,— Virginia-born, with seventeen secesh cousins, fathers, and other relatives,—tell of his late experience at the seat of Government. He is an out-and-out immediate emancipationist,—believes that is the only way to break the strength of the South; that the black man is the life of the South; that they dread work above all things, and cling to the slave as the drudge that makes life tolerable to them. I do not know if his opinion is worth much."

This was a meeting of the Bird Club which Doctor Holmes attended and the dingy-linened friends of progress were such men as Dr. Samuel G. Howe, Governor Washburn, Governor Claflin, Dr. Estes Howe, and Frank B. Sanborn. It has always been a trick of fashionable society, a trick as old as the age of Pericles, to disparage liberalism by accusing it of vulgarity; but we regret to find Doctor Holmes falling into line in this particular. He always speaks of Sumner in his letters with something like a slur—not to Motley, for Motley was Sumner's friend, but to others who might be more sympathetic. This did not, however, prevent him from going to Sumner in 1868 to ask a favor for his second son, who wanted to be private secretary to the Senator and learn something of foreign affairs. Sumner granted the request, although he must have been aware that the Doctor was not over-friendly to him; but it proved an unfortunate circumstance for Edward J. Holmes, who contracted malaria in Washington, and this finally resulted in an early death.

Why is it that members of the medical profession should take an exceptional interest in poisonous reptiles? Professor Reichert and Dr. S. Weir Mitchell spent a large portion of their leisure hours for several years in experimenting with the virus of rattlesnakes, and of the Gila monster, without, however, quite exhausting the subject. Doctor Holmes kept a rattlesnake in a cage for a pet, and was accustomed to stir it up with an ox-goad. A New York doctor lost his life by fooling with a poisonous snake, and another in Liverpool frightened a whole congregation of scientists with two torpid rattlesnakes which suddenly came to life on the president's table. Does it arise from their custom of dealing with deadly poisons, or is it because they officiate as the high priests of mortality?

Doctor Holmes's "Elsie Venner" was one of the offshoots of this peculiar medical interest, and when we think of it in that light the story seems natural enough. The idea of a snaky woman is as old as the fable of Medusa. I read the novel when I was fifteen, and it made as decided an impression on me as "Ivanhoe" or "Pickwick." I remember especially a proverbial saying of the old doctor who serves as the presiding genius of the plot: he knew "the kind of people who are never sick but what they are going to die, and the other kind who never know they are sick until they are dead." If Doctor Holmes had taken this as his text, and written a novel on those lines, he might have created a work of far-reaching importance. He appears to have known very little concerning poisonous reptiles; had never heard of the terrible fer-de-lance, which infests the cane-swamps of Brazil—a snake ten feet in length which strikes without warning and straight as a fencer's thrust. But "Elsie Venner" and Holmes's second novel, "The Guardian Angel," are, to use Lowell's expression on a different subject: