In religious matters Henry Antes displayed much zeal and activity. He became known as the “Pious Layman of Fredericktown.” He taught the proper way of life to his countrymen, frequently calling them together in their homes for prayers, reading of the scriptures and exhortation. He was thus employed in Oley as early as 1736.

In 1740 a great religious revival occurred in Falkner Swamp. George Whitefield, the great revivalist, preached at the house of Christopher Wiegner at Skippack, then later in the day he preached at the house of Henry Antes. About two thousand persons, mostly Germans, with some Quakers, Dunkards, Swedes, Huguenots and other church people were in attendance.

Antes yearned for the unity of the followers of the Christian religion.

On November 24, 1741, Count Zinzindorf came to Philadelphia to unite the leading men of the several denominations in Pennsylvania for evangelical work. John Bechtel indorsed the movement, and Henry Antes issued a call for the first meeting in furtherance of this object to be held in Germantown. In order to command the confidence of German colonists it was necessary that the movement be recommended by one well known to the people, so Antes issued the call.

Because the movement did not meet with success in the way anticipated Henry Antes really died of a broken heart. The Moravian Church, however, was one of the results.

During the session of the Moravian Synod, March, 1745, at the home of Henry Antes, he offered the use of his farm and buildings and his mill for the brethren to be used as boarding school for boys.

On June 3, 1745, the school was started with thirty-four scholars. Christina Francke Christopher, of Bethlehem, was superintendent, and John C. Heyne, a teacher. The Moravians named it Mount Frederick School, and it was the first nonsectarian school in Pennsylvania.

Antes and his family, excepting two sons, John and Henry, who remained as pupils, moved to Bethlehem. Here he gave his whole time to the temporal affairs of the Moravians. He planned and superintended the building of the first mills, dams, bridges and houses at the different Moravian settlements.

On December 15, 1745, he was appointed by King George of England, to be Justice of the Peace for Bucks County, in which Bethlehem was then a part. October 27, 1748, Henry Antes was appointed business manager of the Moravians.

In 1750 Antes withdrew from the Moravians, because he did not approve of the introduction of the wearing of a white surplice by the minister at the celebration of the Eucharist.