The Shawnee, on the Ohio, allied to the French interest, now assumed a hostile attitude. A great convention was held at Albany, October 26, 1745, to which commissioners from New York, Massachusetts, Connecticut and Pennsylvania were sent.

The Six Nations were urged to take up the hatchet against the French and become parties in the war, but the Indians showed no disposition to enter the contest, and the result of the conference was far from being satisfactory.

In May, 1746, Governor Thomas was directed by the Crown to raise forces for a conquest of Canada. After much delay, the Assembly voted £5000, and Governor Thomas raised four companies of over one hundred men each, commanded by Captain William Trent, John Shannon, Samuel Perry and John Deimer, who marched at once to Albany.

The attempt on Canada was postponed, but the troops were retained nearly eighteen months along the Hudson to intimidate the Indians.

John Penn died, and at a meeting of the Assembly held May 5, 1747, Governor Thomas communicated the news of his death, and at the same time, on account of his own ill-health, he resigned his office.

On the departure of Governor Thomas, the executive administration devolved upon the Council, of which Anthony Palmer was president, until the arrival of James Hamilton, son of Andrew Hamilton, former Speaker of the Assembly, as Lieutenant Governor, November 23, 1749.

The crops were abundant in 1751 and 1752, but these years of plenty were followed by a season of want, covering the years 1753–1755, and on the heels of it came Indian hostilities.

The progress of the white population toward the west irritated the Indians. Especially was this true of the Scotch-Irish, who seated themselves on the west of the Susquehanna, on the Juniata, and in the Great and Little Coves formed by the Kittatinny and the Tuscarora hills, and at the Big and Little Connolloways.

The French applied themselves to seduce the Indians from their allegiance to the English. The Shawnee had already joined them, the Delaware awaited an opportunity to avenge their wrongs, and of the Six Nations, the Onondaga, Cayuga and Seneca were wavering.

To keep the Indians in favor of the Province required much cunning diplomacy and expensive presents. A chain of forts and the maintenance of a military force, drew heavily on the Provincial purse, and it is but little wonder that the Assembly and the Proprietaries early divided on questions involving taxes and expenditures. The French and Indian War soon broke in all its fierceness.