In 1849 the Indian Office was transferred by Congress from the War Department to the Interior, with the idea that the Indians would be better off under civilian than military control, and shortly after this negotiations were begun looking towards new settlements with the tribes. The Sioux were persuaded in the summer of 1851 to make way for increasing population in Minnesota, while in the autumn of the same year the tribes of the western plains were induced to make concessions.

The great treaties signed at the Upper Platte agency at Fort Laramie in 1851 were in the interest of the migrating thousands. Fitzpatrick had spent the summer of 1850 in summoning the bands of Cheyenne and Arapaho to the conference. Shoshoni were brought in from the West. From the north of the Platte came Sioux and Assiniboin, Arickara, Grosventres, and Crows. The treaties here concluded were never ratified in full, but for fifteen years Congress paid various annuities provided by them, and in general the tribes adhered to them. The right of the United States to make roads across the plains and to fortify them with military posts was fully agreed to, while the Indians pledged themselves to commit no depredations upon emigrants. Two years later, at Fort Atkinson, Fitzpatrick had a conference with the plains Indians of the south, Comanche and Apache, making "a renewal of faith, which the Indians did not have in the Government, nor the Government in them."

Overland traffic was made more safe for several years by these treaties. Such friction and fighting as occurred in the fifties were due chiefly to the excesses and the fears of the emigrants themselves. But in these treaties there was nothing for the eastern tribes along the Iowa and Missouri border, who were in constant danger of dispossession by the advance of the frontier itself.

The settlement of Kansas, becoming probable in the early fifties, was the impending danger threatening the peace of the border. There was not as yet any special need to extend colonization across the Missouri, since Arkansas, Missouri, Iowa, and Minnesota were but sparsely inhabited. Settlers for years might be accommodated farther to the east. But the slavery debate of 1850 had revealed and aroused passions in both North and South. Motives were so thoroughly mixed that participants were rarely able to give satisfactory accounts of themselves. Love of struggle, desire for revenge, political ambition, all mingled with pure philanthropy and a reasonable fear of outside interference with domestic institutions. The compromise had settled the future of the new lands, but between Missouri and the mountains lay the residue of the Louisiana purchase, divided truly by the Missouri compromise line of 36° 30', but not yet settled. Ambition to possess it, to convert it to slavery, or to retain it for freedom was stimulated by the debate and the fears of outside interference. The nearest part of the unorganized West was adjacent to Missouri. Hence it was that Kansas came within the public vision first.

It is possible to trace a movement for territorial organization in the Indian Country back to 1850 or even earlier. Certain of the more intelligent of the Indian colonists had been able to read the signs of the times, with the result that organized effort for a territory of Nebraska had emanated from the Wyandot country and had besieged Congress between 1851 and 1853. The obstacles in the road of fulfilment were the Indians and the laws. Experience had long demonstrated the unwisdom of permitting Indians and emigrants to live in the same districts. The removal and intercourse acts, and the treaties based upon them, had guaranteed in particular that no territory or state should ever be organized in this country. Good faith and the physical presence of the tribes had to be overcome before a new territory could appear.

The guarantee of permanency was based upon treaty, and in the eye of Congress was not so sacred that it could not be modified by treaty. As it became clear that the demand for the opening of these lands would soon have to be granted, Congress prepared for the inevitable by ordering, in March, 1853, a series of negotiations with the tribes west of Missouri with a view to the cession of more country. The Commissioner of Indian Affairs, George W. Manypenny, who later wrote a book on "Our Indian Wards," spent the next summer in breaking to the Indians the hard news that they were expected once more to vacate. He found the tribes uneasy and sullen. Occasional prospectors, wandering over their lands, had set them thinking. There had been no actual white settlement up to October, 1853, so Manypenny declared, but the chiefs feared that he was contemplating a seizure of their lands. The Indian mind had some difficulty in comprehending the difference between ceding their land by treaty and losing it by force.

At a long series of council fires the Commissioner soothed away some of the apprehensions, but found a stubborn resistance when he came to talk of ceding all the reserves and moving to new homes. The tribes, under pressure, were ready to part with some of their lands, but wanted to retain enough to live on. When he talked to them of the Great Father in Washington, Manypenny himself felt the irony of the situation; the guarantee of permanency had been simple and explicit. Yet he arranged for a series of treaties in the following year.

In the spring of 1854 treaties were concluded with most of the tribes fronting on Missouri between 37° and 42° 40'. Some of these had been persuaded to move into the Missouri Valley in the negotiations of the thirties. Others, always resident there, had accepted curtailed reserves. The Omaha faced the Missouri, north of the Platte. South of the Platte were the Oto and Missouri, the Sauk and Foxes of Missouri, the Iowa, and the Kickapoo. The Delaware reserve, north of the Kansas, and around Fort Leavenworth, was the seat of Indian civilization of a high order. The Shawnee, immediately south of the Kansas, were also well advanced in agriculture in the permanent home they had accepted. The confederated Kaskaskia and Peoria, and Wea and Piankashaw, and the Miami were further south. From those tribes more than thirteen million acres of land were bought in the treaties of 1854. In scattered and reduced reserves the Indians retained for themselves about one-tenth of what they ceded. Generally, when the final signing came, under the persuasion of the Indian Office, and often amid the strange surroundings of Washington, the chiefs surrendered the lands outright and with no condition.

Certain of the tribes resisted all importunities to give title at once and held out for conditions of sale. The Iowa, the confederated minor tribes, and notably the Delawares, ceded their lands in trust to the United States, with the treaty pledge that the lands so yielded should be sold at public auction to the highest bidder, the remainders should then be offered privately for three years at $1.25 per acre, and the final remnants should be disposed of by the United States, the accruing funds being held in trust by the United States for the Indians. By the end of May the treaties were nearly all concluded. In July, 1854, Congress provided a land office for the territory of Kansas.

While the Indian negotiations were in progress, Senator Douglas was forcing his Kansas-Nebraska bill at Washington. The bill had failed in 1853, partly because the Senate had felt the sanctity of the Indian agreement; but in 1854 the leader of the Democratic party carried it along relentlessly. With words of highest patriotism upon his lips, as Rhodes has told it, he secured the passage of a bill not needed by the westward movement, subversive of the national pledge, and, blind as he was, destructive as well of his party and his own political future. The support of President Pierce and the coöperation of Jefferson Davis were his in the struggle. It was not his intent, he declared, to legislate slavery into or out of the territories; he proposed to leave that to the people themselves. To this principle he gave the name of "popular sovereignty," "and the name was a far greater invention than the doctrine." With rising opposition all about him, he repealed the Missouri compromise which in 1820 had divided the Indian Country by the line of 36° 30' into free and slave areas, and created within these limits the new territories of Kansas and Nebraska. His bill was signed by the President on May 30, 1854. In later years this day has been observed as a memorial to those who lost their lives in fighting the battle which he provoked.