SEMEN SABADILLÆ.
Fructus Sabadillæ; Cebadilla, Cevadilla; F. Cévadille; G. Sabadillsamen, Läusesamen.
Botanical Origin—Asagræa officinalis Lindley (Veratrum officinale Schlecht, Sabadilla officinarum Brandt, Schœnocaulon officinale A. Gray).—A bulbous plant, growing in Mexico, in grassy places on the eastern declivities of the volcanic range of the Cofre de Perote, and Orizaba, near Teosolo, Huatusco and Zacuapan, down to the sea-shore, also in Guatemala. Cebadilla is (or was) cultivated near Vera Cruz, Alvarado and Tlacatalpan in the Gulf of Mexico.
Another form of Asagræa, first noticed by Berg,[2609] but of late more particularly by Ernst of Caracas, who thinks it may constitute a distinct species, is found in plenty on grassy slopes, 3,500 to 4,000 feet above the sea-level, in the neighbourhood of Caracas, and southward in the hilly regions bordering the valley of the Tuy.[2610] It differs chiefly in having broader and more carinate leaves.[2611] Of late years it has furnished large quantities of seed, which, freed from their capsules, have been shipped from La Guaira to Hamburg.
History—Cebadilla was first described in 1517 by Monardes, who states that it is used by the Indians of New Spain as a caustic and corrosive application to wounds; but it does not seem to have been brought into European commerce, for neither Parkinson who described it in 1640 as the Indian Causticke Barley, nor Ray (1693) did more than copy from Monardes. It was regarded in Germany a rare drug even in 1726, but in the latter half of the last century it began to be recommended in France and Germany for the destruction of pediculi. A famous composition for this purpose was the Poudre des Capucins, consisting of a mixture of stavesacre, tobacco, and cebadilla, which was applied either dry or made into an ointment with lard.[2612] Cebadilla was also administered combined into a pill with gamboge and valerian,[2613] for the destruction of intestinal worms, but its virulent action made it hazardous.
Upon the introduction of veratrine into medicine about 1824 cebadilla attracted some notice, and was occasionally prescribed in the form of tincture and extract; but it subsequently fell into disuse, and is now only employed for the manufacture of veratrine.
Description—Each fruit consists of three oblong pointed follicles, about ½ an inch in length, surrounded below by the remains of the 6-partite calyx, and attached to a short pedicel. The follicles are united at the base, spread somewhat towards the apex, and open by their ventral suture. They are of a light brown colour and papery substance. Each usually contains two-pointed narrow black seeds, ³/₁₀ of an inch in length, which are shining, rugose, and angular or concave by mutual pressure. The compact testa encloses an oily albumen, at the base of which, opposite to the beaked apex, lies the small embryo. The seed is inodorous and has a bitter acrid taste; when powdered, it produces violent sneezing.
Microscopic Structure—A transverse section shows the horny concentrically radiated albumen, closely attached to the testa. The latter consists of an outer layer of cuboid cells, and three rows of smaller, thin-walled, tangentially-extended cells, all of which have brown walls. The tissue of the albumen is made up of large porous cells, containing drops of oil, granules of albuminoid matter, and mucilage. Traces of tannic acid occur only in the outer layers of the seed.
Chemical Composition—Meissner, an apothecary of Halle, Prussia, in 1819 discovered in cebadilla a basic substance, which he termed Sabadilline; in publishing, in 1821, the description of it the word “alkaloid” was introduced by Meissner at that occasion. The name Veratrine[2614] was applied likewise in 1819 by Pelletier and Caventou to a similar preparation. For many years this substance was known only as an amorphous powder, in which state it frequently contained a considerable proportion of resin; but in 1855 it was obtained by G. Merck in large rhombic prisms. Cebadilla yields only about 3 per mille of veratrine. The alkaloid is easily soluble in spirit of wine, ether or chloroform; these solutions, as well as the watery solutions of its salts, are devoid of rotatory power. Veratrine, like the drug from which it is derived, occasions, if inhaled, prolonged sternutation.
Again, in 1834, Conerbe described an alkaloid from cebadilla under the name of Sabadilline, and Weigelin (1871) another called Sabatrine.