It is from this and other species of Toddalia, or from the allied genus Zanthoxylum,[439] that a drug is derived which under the name of Lopez Root had once some celebrity in Europe. This drug which was more precisely termed Radix Indica Lopeziana or Root of Juan Lopez Pigneiro, was first made known by the Italian physician Redi,[440] who described it in 1671 from specimens obtained by Pigneiro at the mouth of the river Zambesi in Eastern Africa,—the very locality in which in our times Toddalia lanceolata Lam. has been collected by Dr. Kirk.[441] It was actually introduced into European medicine by Gaubius[442] in 1771 as a remedy for diarrhœa, and acquired so much reputation that it was admitted to the Edinburgh Pharmacopœia of 1792. The root appears to have been sometimes imported from Goa, but its place of growth and botanical origin were entirely unknown, and it was always extremely rare andcostly.[443] It has long been obsolete in all countries except Holland, where until recently it was to be met with in the shops. The Pharmacopœia Neerlandica of 1851 says of it “Origo botanica perquam dubia—Patria Malacca?”
Description—The specimen of the root of Toddalia aculeata which we have examined was collected for us by Dr. G. Bidie of Madras whose statements regarding the stimulant and tonic action of the drug may be found in the Pharmacopœia of India, p. 442. It is a dense woody root in cylindrical, flexuous pieces, which have evidently been of considerable length and are from ½ to 1½ inches in diameter, covered with bark ⅒ to ¹/₁₂ of an inch in thickness. The bark has a soft, dull yellowish, suberous coat, wrinkled longitudinally, beneath which is a very thin layer of a bright yellow colour, and still lower and constituting two-thirds or more of the whole, is the firm, brown middle cortical layer and liber, which is the part chiefly possessing the characteristic pungency and bitterness of the drug. The yellow corky coat is however not devoid of bitterness. The wood is hard, of a pale yellow, and without taste and smell. The pores of the wood, which are rather large, are arranged in concentric order and traversed by numerous narrow medullary rays.
In a letter which Frappier[444] wrote to Guibourt from the island of Réunion where Toddalia aculeata is very common, he states that the roots of the plant are of enormous length (longueur incroyable) and rather difficult to get out of the basaltic rock into the fissures of which they penetrate. Mr. J. Horne of the Botanical Garden, Mauritius, has sent us a specimen of the root of this plant, the bark of which is of a dusky brown, with the suberous layer but little developed.
Microscopic Structure—We have examined the root for which we are indebted to Dr. Bidie, and may state that its cortical tissue is remarkable by the number of large cells filled with resin and essential oil; they are scattered through the whole tissue, the cork excepted. The parenchymatous cells are loaded with small starch granules or with crystals of oxalate of calcium. The vessels of younger roots abound in yellow resin.
Chemical Composition—None of the constituents of the Toddalia root of India have yet been satisfactorily examined. The bark contains an essential oil, which would be better extracted from fresh than from dry material. The tissue of the bark is but little coloured by salts of iron. In the aqueous infusion, tannic acid produces an abundant precipitate, probably of an indifferent bitter principle rather than of an alkaloid. We have been unable to detect the presence in the bark of berberine.
Lopez root was examined in Wittstein’s laboratory by Schnitzer[445] who found that the bark contains in addition to the usual substances a large proportion of resin,—a mixture probably of two or three different bodies. The essential oil afforded by the bark had an odour resembling cinnamon and melissa.
Uses—The drug has been introduced into the Pharmacopœia of India chiefly upon the recommendation of Dr. Bidie of Madras, who considers it of great value as a stimulating tonic. The bark rasped or shaved from the woody root is the only part that should be used.
FOLIA PILOCARPI.
Folia Jaborandi.
Botanical Origin—Pilocarpus pennatifolius[446] Lemaire, a slightly branched shrub, attaining about 10 feet in height. It is distributed through the eastern provinces of Brazil.