This manor-house was originally a royal palace, built by Henry VIII., doubtless as a kind of hunting-lodge for the adjacent Marylebone Park, as Regent's Park was then called.

It is said to have been visited by Mary and Elizabeth, and as there are authentic records of the latter Queen's entertainment of the Russian Ambassador here, the statement is probably true. The house was rebuilt and considerably altered when it became the manor-house at a later date, but after having borne this title for many years it was let as a school in 1703, and was pulled down in 1791.

Another house about 100 yards south of this in the High Street has often been confounded with it (the manor-house), but this was built by Edward Harley, second Earl of Oxford, for the reception of the famous Harleian collection of MSS., begun by his father and continued by himself. When this collection was purchased by the British Museum the house, known as Oxford House, became a boarding-school for girls. The grounds stretched out at the back, covering the space now occupied by Beaumont Street, Devonshire Place, and part of Devonshire Street. Some time before the house became a school these grounds were detached, and a noted bowling-green was established here. Lady Mary Wortley Montagu's sharp remark in reference to this, "Some Dukes at Marylebone bowl time away," has often been quoted. There was close to the green a noted tavern called the Rose of Normandy. This is supposed to have been built in the early half of the seventeenth century, and was a well-known resort of gamesters and idlers. Sheffield, Duke of Buckingham, against whom Lady Mary's sally was principally directed, is said to have spent much of his time there. He used to give a dinner to his associates at the end of the season, and his parting toast was, "May as many of us as remain unhanged meet here again next spring." In a plan of the Duke of Portland's estate in 1708 two bowling-greens are shown, one in the gardens at the back of the manor-house, and one behind the tavern. Both of these bowling-greens were afterwards incorporated into the famous Marylebone Gardens.

These Gardens were entered through the tavern above mentioned, and were opened before 1737; up to that date the public had free access, but afterwards were admitted only on payment of one shilling, for which, however, they received an equivalent of "tea before eight o'clock," or "half a pint of wine during the concert." There was a theatre in the Gardens, in which balls, concerts, and scenic displays took place. The musical department was for some time under the direction of Dr. Arne, and the fireworks under Signor Torre. An allegorical play was performed on June 4, 1772, in honour of the King's birthday.

In 1778 the Gardens were closed, complaints having been made by the inhabitants as to the danger of fire from the fireworks. Pepys mentions the Gardens as "a pretty place," and John Locke records "bowling at Marebone and Putney by persons of quality." These Gardens formed the scene of McHeath's debauchery in the "Beggars' Opera." Devonshire Place, built on the site, is a fine wide street.

Almost opposite to the church, on the north side of the Marylebone Road, is the Charity School for Girls, a large, well-built edifice, which stands back behind a high brick wall. An inscription on this wall proclaims "St. Marylebone Charity School for the maintenance and education of the daughters of poor inhabitants. Supported solely by voluntary contributions. Founded 1750. Moved to this date 1838."

In 1750 a few benevolent gentlemen inaugurated the scheme, and at first its benefits were open to boys and girls alike. In 1754 the Dowager Countess of Oxford, having granted a piece of land in High Street for the term of 999 years at peppercorn rent, the school house was erected. The numbers of the children varied according to the income. In 1829 it was considered advisable to devote the charity exclusively to girls, and the boys were dispersed. In 1838 the present schoolhouse was built on ground leased from the Duke of Portland. P. Hardwicke was the architect, and the result is entirely satisfactory.

The girls enter at ten, or two years earlier if they are paying pupils, and remain till sixteen. They make everything for themselves at the school excepting hats and boots, and do all their own domestic work, the kitchen and laundry being under the superintendence of a cook and laundress. Large orders of needlework are executed, but the mornings are devoted to bookwork.

They still wear the picturesque dress of the time of the establishment of the foundation. On Sundays they are dressed in brown frocks with elbow sleeves and mittens, and wear white fichus and aprons and snowy Dutch caps, like the children of the Foundling Hospital. The building is on the site of Marylebone Park House, an old house, parts of which the architect has incorporated into its successor; a handsome oak floor and marble mantelpiece of the Queen Anne period are to be seen in the board-room. At its southern end High Street bifurcates, becoming Thayer Street and Marylebone Lane.

In 1839 Charles Dickens came to a large house in Devonshire Terrace, facing York Gate. This was his home for eleven years, during which appeared "Martin Chuzzlewit," "Dombey and Son," "David Copperfield," and many minor works.