On the west side of the Square is Portland House, a heavy stone edifice of great size standing back behind a high brick wall. The stables and grounds connected with it stretch through to Wimpole Street. The house was first called Bingley, and later Harcourt House. It was designed by Inigo Jones for Lord Bingley in 1722-23, and purchased after his death by the Earl of Harcourt, and when it was bought by the Duke of Portland, it was for a second time renamed. This was the only house standing when the Duke of Chandos designed his palace. The ground was then worth 2s. 6d. a square foot. In 1833 a man then living remembered a fox being killed in the Square.

The streets leading from the Square are all of about the same date, and were built or laid out in the eighteenth century. At No. 24, Holles Street Lord Byron was born.

Chandos House in Chandos Street was a part of the original house designed by the Duke of Chandos. A long, low, rough, stuccoed building, containing the Medical Society of London, is here also, besides numerous offices of other societies, mostly medical.

In Queen Anne Street, No. 23 contains the offices of the Portland estate. It is a quaintly-built house, quite modern, with a commemorative tablet to Turner, R.A., who lived here. At No. 72 Fuseli formerly lived. Portland Place was built about 1772, and measures 126 feet in width. It is one-third of a mile long, and was designed by the brothers Adam. It was Nash's fancy to make Regent Street run straight on into Portland Place to lead up to a palace to be built for the King in Regent's Park, but this design was subsequently abandoned. The Chinese Embassy is in No. 49.

On the site of the Langham Hotel originally stood Foley House, built by the Duke of Foley. In his lease with the Duke of Portland it was expressly stipulated that no other house should be built to block the view northward. Thus, when Portland Place was built, it was made of the present enormous width in consequence of this stipulation. Foley House was demolished in 1820, and part of the site was bought by Sir James Langham, whose name is preserved in the adjacent street. The well-known architect, Nash, was employed by him to build a house, but Sir James was dissatisfied with the construction. It is said that Nash, then employed in carrying out Langham Place, made it curve, to spite his employer, instead of carrying it on in a continuous line to Portland Place, as was at first designed.

All Souls' Church is also Nash's work. This church was built 1822-24, and is of a curious design with a circular portico surrounding a circular tower surmounted by a spire. The altar-piece is by Westall, R.A. The church was restored in 1876. Dr. Thomson, late Archbishop of York, and Bishop Baring of Durham, were among the former incumbents.

Queen's Hall, close by, is used for concerts and entertainments.

The London Crystal Palace, erected in 1858, stood formerly on the site of a great drapery establishment at the north-east corner of Regent Circus.

Halfway down the part of Regent Street above the Circus is the Polytechnic Young Men's Christian Institute and Day Schools, also the Polytechnic School of Art, founded in 1838, and enlarged ten years later. It was originally intended for the exhibition of novelties in the Arts and practical Sciences, especially agriculture and other branches of industry. Exhibitions were held here and lectures and classes established, but in 1881 the building was sold, and is now used as above indicated.

Margaret Street was named after Margaret, heiress of the Newcastle and Oxford families. In it is All Saints' Church, a decorative building which has been described as the most beautiful church in the Metropolis. It was built by W. Butterfield, and the first stone was laid by Dr. Pusey on All Saints' Day, November 1, 1850. The whole of the interior is covered by mural decorations. The frescoes in the chancel were executed by W. Dyce, R.A. The style is Early English, and the spire reaches a height of 227 feet.