Question.—“In what way does it operate, in your opinion?”
Answer.—“It is first absorbed into the blood, then circulated through the body, and especially acts on the spinal cord, from which proceed the nerves acting on the voluntary muscles.”
Question.—“Supposing the poison has been absorbed, what time would you give for the circulating process?”
Answer.—“The circulation of the blood through the whole system is considered to take place about once in four minutes. The circulation in animals is quicker. The absorption of the poison by rabbits is therefore quicker. The time would also depend on the state of the stomach,—whether it contained much food or not, whether the poison came into immediate contact with the inner surface of the stomach.”
Question.—“In your opinion, does the poison act immediately on the nervous system, or must it first be absorbed?”
Answer.—“It must first be absorbed.”
Question.—“The symptoms, you say, are uniform. Will you describe them?”
Answer.—“The animal for about five or six minutes does not appear to suffer, but moves about gently; when the poison begins to act it suddenly falls on its side; there is a trembling, a quivering motion of the whole of the muscles of the body, arising from the poison producing violent and involuntary contraction. There is then a sudden paroxysm or fit, the fore legs and the hind legs are stretched out, the head and the tail are drawn back in the form of a bow, the jaws are spasmodically closed, the eyes are prominent; after a short time there is a slight remission of the symptoms, and the animal appears to lie quiet, but the slightest noise or touch reproduces another convulsive paroxysm; sometimes there is a scream, or a sort of shriek, as if the animal suffered from pain; the heart beats violently during the fit, and after a succession of these fits the animal dies quietly. Sometimes, however, the animal dies during a spasm, and I only know that death has occurred from holding my hand over the heart. The appearances after death differ. In some instances the rigidity continues. In one case the muscles were so strongly contracted for a week afterwards, that it was possible to hold the body by its hind legs stretched out horizontally. In an animal killed the other day the body was flaccid at the time of death, but became rigid about five minutes afterwards. I have opened the bodies of animals thus destroyed.”
Question.—“Could you detect any injury in the stomach?”
Answer.—“No. I have found in some cases congestion of the membranes of the spinal cord to a greater extent than would be accounted for by the gravitation of the blood. In other cases I have found no departure from the ordinary state of the spinal cord and the brain. I ascribe congestion to the succession of fits before death. In a majority of instances, three out of five, I found no change in the abnormal condition of the spine. In all cases the heart has been congested, especially the right side. I saw a case of ordinary tetanus in the human subject years ago, but I have not had much experience of such cases. I saw one case last Thursday week at St. Bartholomew’s Hospital. The patient recovered.”