Question.—“Suppose half a grain to be absorbed into the blood, what proportion does it bear to the total quantity of blood circulated in the system?”
Answer.—“Assuming the system to contain the lowest quantity of blood—25lb.—it would be one-fiftieth of a grain to a pound of blood. A physician once died from a dose of half a grain in twenty minutes. I believe it undergoes some partial change in the blood which increases the difficulty of discovering it. I never heard of its being separated from the tissues in a crystallised state. The crystals are peculiar in form, but there are other organic crystallised substances like them, so that a chemist will not rely on form only. After the post-mortem examination, a portion of the stomach was delivered to me by Mr. Boycott, covered with bladder, tied and sealed. The jar contained the stomach and the intestines. I have experimented upon them with a view to discover if any poison was present. I sought for prussic acid, morphia, strychnia, veratria, tobacco poison, hemlock, arsenic, antimony, mercury, and other mineral poisons, but only found small traces of antimony. The parts on which I had to operate were in the most unfavourable condition that could possibly be. The stomach had been cut completely from end to end; all the contents were gone, and the fine mucous surface, on which any poison, if present, would have been found, was lying in contact with the outside of the intestines—all thrown together. The inside of the stomach was lying in a mass of intestinal fœcal matter. That was, I presume, the fault or misfortune of the person who dissected, but it seemed to have been shaken about in every possible way in its journey to London.[48] By my request the spleen, two kidneys, and a small bottle of blood, were sent up to me. We had no idea where the blood came from. Each part of the liver, one kidney, and the spleen, all yielded antimony. It was reproduced, or brought out by boiling the animal matter in a mixture of hydrochloric acid and water. Copper, in the shape of foil and gauze in a sort of web of fine copper, was introduced, and the antimony was found deposited on the copper. The quantity of antimony was less in proportion in the spleen than in the other parts. I detected some antimony in the blood. We applied the tests of Professor Brande, Dr. Rees, and others. It is impossible to say how recently it had been administered, but I should say shortly before death, that is, within some days. The longest period at which antimony can be found in the blood after death, within my knowledge, is eight days; the earliest period, within my knowledge, eighteen hours. A boy died within eighteen hours after taking it, and it was found in his liver. It is usually given in the form of tartar emetic; it acts as an irritant, and produces vomiting. If given in repeated doses, a portion would find its way into the blood and the system, beyond what was ejected. If it continued to be given after it had produced certain symptoms, it would destroy life. It may, however, be given with impunity.”
Referring to the symptoms previously proved in Cook’s case, the witness said—
“Vomitings produced by antimony would cause those symptoms. If given in small quantities, sufficient to cause vomiting, it would not affect the colour of the liquid with which it was mixed, whether brandy, wine, broth, or water. It is impossible to form an exact judgment when the antimony was administered, but it must have been two or three weeks at the outside before death. There was no evidence that it was administered within some hours before death. It might leave a sensation in the throat—a choking sensation—if a large quantity was given at once. I found no trace of mercury during the analysis. If a few grains had been taken recently before death, I should have expected to find some trace. If a man had taken mercury for a syphilitic affection within two or three weeks, I should have expected to find it. It is very slow in passing out of the body. As small a quantity as three or four grains might leave some trace. I recollect a case in which three grains of calomel were given three or four hours before death, and traces of mercury were found. Half a grain three or four days before death, if given in divided doses more favourable for absorption, would, I should expect, leave a trace. One grain would certainly do so.” The witness agreed with the opinion of the other witnesses as to the causes of the deaths of Mrs. Smyth, Agnes French, and the other lady (Mrs. Dove), and of the attack of Clutterbuck, and that the symptoms in Mr. Cook’s case appeared to be of a similar character. As a professor of medical science, he did not know any cause in the range of human disease, except strychnia, to which the symptoms in Cook’s case could be referred.
The cross-examination of Dr. Taylor was necessarily very diffuse and lengthy; with the exception, however, of the part in which it was sought to raise a prejudice against the witness as a partisan, to which I have previously referred, it was so important that, like the examination in chief, it must, in justice to all parties, be reported at length.
Cross-examined by Mr. Serjeant Shee.—“I mean by the word ‘trace’ a very small quantity, which can hardly be estimated by weight. I do not apply it in the sense of an imponderable quantity. In chemical language it is frequently used in that sense. An infinitesimal quantity would be called ‘a trace.’ The quantity of antimony that we discovered in all parts of the body would make up about half a grain. We did not ascertain that there was that quantity, but I will undertake to say that we extracted as much as half a grain. That quantity would not be sufficient to cause death. Only arsenic or antimony could have been deposited, under the circumstances, on the copper, and no sublimate of arsenic was obtained.” [The witness, in reply to a further question, detailed the elaborate test which he had applied to the deposit, in order to ascertain that it consisted of antimony.]
Question.—“Would a mistake in any one of the processes you have described, or a defect in any of the materials you have used, defeat the object of the test?”
Answer.—“It would, but all the materials I used were pure. Such an accident could not have happened without my having some intimation of it in the course of the process. I should think antimony would operate more quickly upon animals than upon men. I am acquainted with the works of Orfila. He stood in the highest rank of analytical chemists.”
Question.—“Did not Orfila find antimony in a dog four months after injection?”
Answer.—“Yes; but the animal had taken about forty-five grains.”