Answer.—“That might be. It would depend upon the quantity of food in the stomach with which it was mixed.”
Re-examined by the Attorney-General.—“In cases of death from strychnia the heart is sometimes found empty after death. That is the case of human subjects. There are three such cases on record. I think that emptiness results from spasmodic affection of the heart. I know of no reason why that should rather occur in the case of man than in that of a small animal like a rabbit. The heart is generally more filled when the paroxysms are frequent. When the paroxysm is short and violent, and causes death in a few moments, I should expect to find the heart empty. The rigidity after death always affects the same muscles; those of the limbs and back. In the case of the rabbit, in which the rigidity was relaxed at the time of death, it returned while the body was warm. In ordinary death it only occurs when the body is cold, or nearly so. I never knew a case of tetanus in which the rigidity lasted two months after death; but such a fact would give me the impression that there were very violent spasms. It would indicate great violence of the spasms from which the person died. The time which elapses between the taking of strychnia and the commencement of the paroxysms depends on the constitution and strength of the individual. A feeling of suffocation is one of the earliest symptoms of poisoning by strychnia, and that would lead the patient to beat the bedclothes. I have no doubt that the substances I used for the purpose of analysis were pure. I had tested them. The fact that three distinct processes each gave the same result was strong confirmation of each. I have no doubt that what we found was antimony. The quantity found does not enable me to say how much was taken. It might be the residue of either large or small doses. Sickness would throw off some portion of the antimony which had been administered. We did not analyse the bones and tissues. I suggested questions to the coroner because he did not put such as enabled me to form an opinion. I think that arose rather from want of knowledge than intention. There was an omission to take down the answers. At the time I wrote to Mr. Gardiner I had not learnt the symptoms which attended the attack and death of Cook. I had only the information that he was well seven days before he died, and had died in convulsions. I had not information to lead me to suppose that strychnia had been the cause of death, except that Palmer had purchased strychnia. Failing to find opium, prussic acid, or strychnia, I referred to antimony as the only substance found in the body. Before writing to the Lancet, I had been made the subject of a great many attacks. What I had said as to the possibility or impossibility of discovering strychnia after death had been misrepresented. In various newspapers it had been represented that I had said strychnia could never be detected—that it was destroyed by putrefaction. What I had said was, that when absorbed in the blood it could not be separated as strychnia. I wrote the letter in my own vindication.”
Dr. Rees and Professor Brande briefly but decidedly confirmed the statements, and coincided with the opinions expressed by Dr. Taylor, the latter witness speaking as to an experiment made by him to test the accuracy of the previous one, with reference to the supposed presence of antimony, which enabled him to state positively that that poison was isolated by it. Professor Christison, of the University of Edinburgh, author of the well-known treatise on poisons, was then called, and gave the following evidence:—
Professor Christison said:—“I am a fellow of the Royal College of Physicians and Professor of Materia Medica to the University of Edinburgh; I am also the author of a work on the subject of poisons, and I have directed a good deal of attention to strychnia. In my opinion it acts by absorption into the blood, and through that upon the nervous system. I have seen its effects upon a human subject, but not a fatal case. I have seen it tried upon pigs, rabbits, cats, and one wild boar. (A laugh.) I first directed my attention to this poison in 1820, in Paris. It had been discovered two years before in Paris. In most of my experiments upon animals I gave very small doses—a sixth of a grain; but I once administered a grain. I cannot say how small a dose would cause the death of an animal by administration into the stomach. I generally applied it by injection through an incision in the cavity of the chest. A sixth part of a grain so administered killed a dog in two minutes. I once administered to a rabbit, through the stomach, a dose of a grain. I saw Dr. Taylor administer three-quarters of a grain to a rabbit, and it was all swallowed except a very small quantity. The symptoms are nearly the same in rabbits, cats, and dogs. The first is a slight tremor and unwillingness to move; then frequently the animal jerks its head back slightly; soon after that all the symptoms of tetanus come on which have been so often described by the previous witnesses. When the poison is administered by the stomach death generally takes place between a period of five minutes and five and twenty minutes after the symptoms first make their appearance. I have frequently opened the bodies of animals thus killed, and have never been able to trace any effect of the poison upon the stomach or intestines, or upon the spinal cord or brain, that I could attribute satisfactorily to the poison. The heart of the animal generally contained blood in all the cases in which I have been concerned. In the case of the wild boar the poison was injected into the chest. A third of a grain was all that was used, and in ten minutes the symptoms began to show themselves. If strychnia was administered in the form of a pill it might be mixed with other ingredients that would protract the period of its operation. This would be the case if it were mixed with resinous materials, or any materials that were difficult of digestion, and such materials would be within the knowledge of any medical men, and they are frequently used for the purpose of making ordinary pills. Absorption in such a case would not commence until the pill was broken down by the process of digestion. In the present state of our knowledge of the subject I do not think it is possible to fix the precise time when the operation of the poison commences on a human subject. In the case of an animal we take care that it is fasting, and we mix the poison with ingredients that are readily soluble, and in every circumstance favourable for the development of the poison. I have seen many cases of tetanus arising from wounds and other causes. The general symptoms of the disorder very nearly resemble each other, and in all the natural forms of tetanus the symptoms begin and advance much more slowly, and they prove fatal much more slowly, and there is no intermission in certain forms of natural tetanus. In tetanus from strychnia there are short intermissions. I have heard the evidence of what took place at the ‘Talbot Arms’ on the Monday and Tuesday, and the result of my experience induces me to come to the conclusion that the symptoms exhibited by the deceased were only attributable to strychnia, or the four poisons containing it: namely, nux vomica, St. Ignatius’s bean, snakewood, and a draught poison called “exhetwick.”[52] There is no natural disease of any description that I am acquainted with to which I could refer these symptoms. In cases of tetanus consciousness remains to the very last moment. When death takes place in a human subject by spasm it tends to empty the heart of blood. When death is the consequence of the administration of strychnia, if the quantity is small, I should not expect to find any trace in the body after death. If there was an excess of quantity more than was required to cause the death by absorption, I should expect to find that excess in the stomach. The colour tests for the detection of the presence of strychnia are uncertain. Vegetable poisons are more difficult of detection than mineral ones, and there is one poison with which I am acquainted for which no known test has been discovered. The stomach of the deceased was sent in a very unsatisfactory state for examination, and there must have been a considerable quantity of strychnia in the stomach to have enabled any one to detect its presence under such circumstances.”
Cross-examined by Mr. Grove.—“The experiments I refer to were made many years ago. In one instance I tried one of the colour tests in the case of a man who was poisoned by strychnia, but I failed to discover the presence of the poison in the stomach. I tried the test for the development of the violet colour by means of sulphuric acid and oxide of lead. From my own observation I should say that animals destroyed by strychnia die of asphyxia, but in my work, which has been referred to, it will be seen that I have left the question open.”
Some further questions were put to the witness by the learned counsel for the prisoner in reference to opinions expressed by him in his work, and he explained that this work was written twelve years ago, and that the experience he had since obtained had modified some of the opinions he then entertained.
Cross-examination continued.—“I have not noticed that in cases where a patient is suffering from strychnia the slightest touch appears to bring on the paroxysm. It is very remarkable in the case of animals, unless you touch them very gently indeed. Strychnia has a most intensely bitter taste. It is said on the authority of a French chemist that a grain will give a taste to more than a gallon of water. If resinous substances were used in the formation of a pill it does not follow that they would necessarily be found in the stomach; they might be passed off.”
By the Attorney-General.—“One of the cases quoted in the work that has been referred to was that of a gamekeeper, who was found dead; his head was thrown back, his hands were clenched, and his limbs were rigid. A paper containing strychnia was found in his pocket, and upon a post-mortem examination, there were indications which, under the circumstances, satisfied me of the existence of strychnia. There was a substance in the body of an intensely bitter taste, which was tested by the colour test, and it succeeded in one instance, but failed in another. It appears that colour tests are not to be relied upon in the case of strychnia in an impure condition: in the first place, you may not find indication of strychnia: and, secondly, they are subject to fallacy even if the strychnia is pure from other substances not containing strychnia presenting similar appearances.”
With the examination of this witness, the medical and scientific evidence for the prosecution was closed.