The first recorded purchase of drugs made directly by Congress, on September 23, was "a parcel of Drugs in the hands of Mr. Rapalje, which he offers at the prime cost."[11] Then, on November 10, Congress ordered that the medicine purchased in Philadelphia for the army at Cambridge be sent there by land.[12] But difficulties of supply commenced early. On January 1, 1776, Eliphalet Dyer wrote Joseph Trumbull asking "how could the cask of Rhubarb which was sent by order of Congress and was extremely wanted in the Hospital lye by to this time. After you came way I wrote to Daniel Brown to see it delivered."[13]
In the fall of 1775 there must have been a reasonably good stock of drugs in the hands of private Philadelphia druggists, and until the end of summer there were still a number of ships from Jamaica, Bermuda, Antigua, and Barbados putting in at Philadelphia with supplies, much of which originally came from England. Philadelphia druggists included William Drewet Smith, "Chemist and Druggist at Hippocrates's Head in Second Street";[14] Dr. George Weed in Front Street;[15] Robert Bass, "Apothecary in Market-Street"; Dr. Anthony Yeldall "at his Medicinal Ware-House in Front-Street";[16] and the firm of Sharp Delaney and William Smith.[17] The largest pharmacy in Philadelphia was operated by the Marshall brothers—Christopher Jr. and Charles. This pharmacy had been established in 1729 at Front and Chestnut Streets by Christopher Marshall, Sr., a patriot who took an active part in the care of the sick and wounded in Philadelphia hospitals during the Revolution.[18]
As the plans progressed for raising troops from New Jersey, Maryland, Delaware, Pennsylvania, Virginia, North Carolina, and South Carolina, Congress called on the committee on medicines "to procure proper medicine chests for the battalions...."[19] The journal of the Continental Congress fails to indicate the source of these medicine chests, but the Marshall brothers' manuscript "waste book" (daily record) for the period February 21 to July 6, 1776,[20] indicates that the Marshall apothecary shop was the primary supplier. The records show that the Marshalls furnished 20 medicine chests to the following battalions from February to June:[21]
| February 1776: | Pennsylvania 1st Battalion |
| March 1776: | Jersey 3d Battalion |
| April 1776: | Pennsylvania 2d, 3d, and 6th Battalions |
| May 1776: | Six Virginia battalions Jersey 1st Battalion Pennsylvania 4th Battalion |
| June 1776: | Six North Carolina battalions Virginia 9th Battalion |
The exact contents of each chest are indicated in the Marshalls' waste book. The chest furnished to the Pennsylvania 4th Battalion is an example of the ones supplied by Congress in the spring of 1776; its contents are listed on page 130.
Congress intended that all chests be substantially the same, but the amount of medicines demanded exceeded the stock of even the largest druggists. The first several chests were complete as ordered, but as early as April the Marshalls were running out of certain drugs. Gum opium and nitre "found by Congress" was included in the chest for the Pennsylvania 4th Battalion, and by May 11 the Marshalls were out of Peruvian bark, ipecac, cream of tartar, gum camphor, and red precipitate of mercury. The chests outfitted after June 1 also failed to include Epsom salts, and the last chest lacked jalap as well. Thus the majority of the battalions traveling north were already without some of the most necessary drugs in their chests. Blithely their medical officers thought they could obtain the missing drugs when they arrived at the general hospital.
Treason, Poison, and Siege
After the Battle of Bunker Hill, the forces around Boston settled down for a 9-month siege. Two days after General Washington arrived in Cambridge on July 2, 1775, to take command of the army, the Provincial Congress of Massachusetts ordered a committee to prepare a letter informing him of the provisions that had been made for the sick and wounded of the army. On the very same day, July 4, the Provincial Congress appointed Andrew Craigie medical commissary and apothecary for the Massachusetts army.[22]
Following a personal inspection by Washington on July 21 and the establishment of the general hospital plan on July 27, the Continental Congress elected Dr. Benjamin Church as director general of the newly created medical department. Soon after this, Church conferred with several Massachusetts officials regarding the appointment of apothecaries for the medical store at Watertown. On August 3, a committee of the Provincial Congress advised "that the Medical Store in Watertown be continued where it now is, and that Mr. Andrew Craigie, appointed by the late Congress Apothecary to the Colony, be directed to take charge thereof, and prepare the necessary compositions; and that Mr. James Miller Church be appointed Assistant Apothecary to put up and distribute said Medicines...."[23]
The medical supplies were slow in coming from Philadelphia, as we have already noted. On the other hand, troops were arriving daily, placing an increased demand on all types of supplies, including drugs. One event which undoubtedly resulted in delays in establishing proper supply depots was the startling discovery that Director General Church was guilty of holding treasonable correspondence with the enemy. On October 16, Congress elected Dr. John Morgan to replace Church.[24]