In 1776 certain gentiles, who were hostile to some Indians that were sheltered by the padres, attacked the Mission by discharging burning arrows upon the tule roof of the buildings, and everything was destroyed, save the church and the granary. Rivera came at once, captured two of the ringleaders, and sent them for punishment to the Monterey presidio. The success of the gentiles led them to repeat their attacks by setting fire to the Mission twice during the next ten years, and it was these calamities that led one of the San Luis padres to attempt the making of roof tiles. Being successful, it was not long before all the Missions were so roofed.

In 1794 certain of the neophytes of San Luis and La Purísima conspired with some gentiles to incite the Indians at San Luis to revolt, but the arrest and deportation of fifteen or twenty of the ringleaders to Monterey, to hard labor at the presidio, put a stop to the revolt.