Other mysterious cases besides those of the Williams sisters revealed the Bluebeard-like character of this latterday castle of Mr. Holmes. In 1887 a man of the name of Connor entered Holmes' employment. He brought with him to the castle a handsome, intelligent wife and a little girl of eight or nine years of age.

After a short time Connor quarrelled with his wife and went away, leaving Mrs. Connor and the little girl with Holmes. After 1892 Mrs. Connor and her daughter had disappeared, but in August, 1895, the police found in the castle some clothes identified as theirs, and the janitor, Quinlan, admitted having seen the dead body of Mrs. Connor in the castle. Holmes, questioned in his prison in Philadelphia, said that Mrs. Connor had died under an operation, but that he did not know what had become of the little girl.

In the year of Mrs. Connor's disappearance, a typist named Emily Cigrand, who had been employed in a hospital in which Benjamin Pitezel had been a patient, was recommended by the latter to Holmes. She entered his employment, and she and Holmes soon became intimate, passing as "Mr. and Mrs. Gordon." Emily Cigrand had been in the habit of writing regularly to her parents in Indiana, but after December 6, 1892, they had never heard from her again, nor could any further trace of her be found.

A man who worked for Holmes as a handy man at the castle stated to the police that in 1892 Holmes had given him a skeleton of a man to mount, and in January, 1893, showed him in the laboratory another male skeleton with some flesh still on it, which also he asked him to mount. As there was a set of surgical instruments in the laboratory and also a tank filled with a fluid preparation for removing flesh, the handy man thought that Holmes was engaged in some kind of surgical work.

About a month before his execution, when Holmes' appeals from his sentence had failed and death appeared imminent, he sold to the newspapers for 7,500 dollars a confession in which he claimed to have committed twenty-seven murders in the course of his career. The day after it appeared he declared the whole confession to be a "fake." He was tired, he said, of being accused by the newspapers of having committed every mysterious murder that had occurred during the last ten years. When it was pointed out to him that the account given in his confession of the murder of the Pitezel children was clearly untrue, he replied, "Of course, it is not true, but the newspapers wanted a sensation and they have got it." The confession was certainly sensational enough to satisfy the most exacting of penny-a-liners, and a lasting tribute to Holmes' undoubted power of extravagant romancing.

According to his story, some of his twenty-seven victims had met their death by poison, some by more violent methods, some had died a lingering death in the air-tight and sound-proof vault of the castle. Most of these he mentioned by name, but some of these were proved afterwards to be alive. Holmes had actually perpetrated, in all probability, about ten murders. But, given further time and opportunity, there is no reason why this peripatetic assassin should not have attained to the considerable figure with which he credited himself in his bogus confession.

Holmes was executed in Philadelphia on May 7, 1896. He seemed to meet his fate with indifference.

The motive of Holmes in murdering Pitezel and three of his children and in planning to murder his wife and remaining children, originated in all probability in a quarrel that occurred between Pitezel and himself in the July of 1894. Pitezel had tired apparently of Holmes and his doings, and wanted to break off the connection. But he must have known enough of Holmes' past to make him a dangerous enemy. It was Pitezel who had introduced to Holmes, Emily Cigrand, the typist, who had disappeared so mysteriously in the castle; Pitezel had been his partner in the fraudulent appropriation of Miss Minnie Williams' property in Texas; it is more than likely, therefore, that Pitezel knew something of the fate of Miss Williams and her sister. By reviving, with Pitezel's help, his old plan for defrauding insurance companies, Holmes saw the opportunity of making 10,000 dollars, which he needed sorely, and at the same time removing his inconvenient and now lukewarm associate. Having killed Pitezel and received the insurance money, Holmes appropriated to his own use the greater part of the 10,000 dollars, giving Mrs. Pitezel in return for her share of the plunder a bogus bill for 5,000 dollars. Having robbed Mrs. Pitezel of both her husband and her money, to this thoroughgoing criminal there seemed only one satisfactory way of escaping detection, and that was to exterminate her and the whole of her family.

Had Holmes not confided his scheme of the insurance fraud to Hedgspeth in St. Louis prison and then broken faith with him, there is no reason why the fraud should ever have been discovered. The subsequent murders had been so cunningly contrived that, had the Insurance Company not put the Pinkerton detectives on his track, Holmes would in all probability have ended by successfully disposing of Mrs. Pitezel, Dessie, and the baby at the house in Burlington, Vermont, and the entire Pitezel family would have disappeared as completely as his other victims.

Holmes admitted afterwards that his one mistake had been his confiding to Hedgspeth his plans for defrauding an insurance company—a mistake, the unfortunate results of which might have been avoided, if he had kept faith with the train robber and given him the 500 dollars which he had promised.