The commonwealth of cells

by H. G. F. Spurrell

But just as atoms combine to form molecules, so the smaller molecules sometimes enter into combinations with one another to form new compounds having larger and more complex molecules. Such a compound is said to be composed of radicles, or groups of atoms, and on being decomposed can be broken up, first into simpler compounds, which can afterwards be further divided into their constituent elements.

Now, of all substances, protoplasm seems to consist of the largest number of components, and to have them arranged in the most complicated way known; though ‘known’ is really not the right word to use in this connection. The reason why we do not know what life is, is that we cannot find out in what way the constituent compounds in the protoplasmic structure are combined. Directly we try to analyze protoplasm, it dies; that is, it splits up into a number of simpler bodies and is altered beyond reconstruction.

These compounds into which protoplasm breaks up when it dies are themselves extremely complex; but though much careful study has been bestowed upon them, we cannot as yet say how they are put together to form the living substance. Protoplasm is too variable a body to be considered a single compound, while, on the other hand, the chemical relationships of its components must be too close to admit of its being called a mixture. Its chemical position is therefore unique, and we can only speak of it as a substance of unknown composition.

What, then, is it that makes protoplasm unmistakable and different to all other substances? The complexity of its structure is, after all, merely a matter of degree. The difference is not easily defined, but it roughly amounts to this: Protoplasm is always changing, yet always remains the same. Life is the change in the molecules.

If our definition of life seemed obscure, this sounds like a paradox; but perhaps the following fact may help to explain it: Under certain conditions some of the simpler compounds behave in a somewhat similar way. For instance, there is one which is so greedy of oxygen that it grabs it from whatever will readily give it up, and in order to do so is obliged to relinquish that which it has already got in its molecule to make room for that freshly acquired. Protoplasm is always behaving in this sort of way as long as it is protected from extremes of heat and cold, and from active chemicals which split up its molecules to form fresh compounds. Then it dies, or ceases to be protoplasm.

But the importance of this constant change lies in the fact that by continually breaking down its own molecules protoplasm obtains the energy to rebuild them out of non-living compounds of high potential energy, to modify its environment, and, in fact, to do the work of life.

It was said above that protoplasm only continued to exist in the form of a cell; therefore, what is a cell, and why its necessity?

We have seen that protoplasm has a very complicated structure, and that its normal condition is one of change. This being so, it obviously cannot exist in large masses, for if it did the change would be sure to be uneven in different parts from its very complexity; and the centre of the lump would either be starved or poisoned by the products of its own life. To avoid this, the mass is divided up into a vast number of small units each complete in itself, in communication more or less direct with its neighbours, and all equally accessible to fluids which both feed and cleanse them.

But there is another and still more important reason for such a division. The protoplasm is constantly discharging decomposition products, and needs to be repairing its waste by building in fresh compounds. The raw material around it requires dressing before it can be of use, and the building in is a difficult business. In each cell there is, therefore, a place set apart, where the protoplasm has peculiar capabilities, and it is here that this elaboration is carried out. This spot is called the nucleus. Thus it will be seen that the formation of an animal’s body by the aggregation of cells is a necessary and ingenious way of avoiding a difficulty.