Deposits of stellar phosphates are of frequent occurrence.

My correspondents report as follows:—

Irritability of the bladder, with tenesmus,21instances.
Hemorrhage from the urinary organs,6”
Retention of urine,11”
“Atony” and paralysis,7”
Albuminuria,23”
Reduction of copper test,16”
Casts in urine,7”

SEXUAL ORGANS.

The evidence as to the effect of the continued use of chloral on the sexual apparatus is meagre and conflicting. The sexual appetite seems to be at first decidedly increased, but finally greatly impaired or lost. Such an increase was observed in one case by Dr. J. A. Miller, of Williamsburg, Ky. (non-habituè). I have seen a decided increase in two cases from occasional small doses, where the effect could have been due to nothing but the chloral; and in one case, by Dr. John N. Upshur,[80] where it had been used for weeks, with large doses of the bromides, in a case of tetanus in a negro.

On the other hand, Dr. Edward Bradley, of this city, writes me that in ten cases he has found decided decrease in sexual appetite and inability to have an erection in patients taking chloral for a short time. It disappeared shortly after stopping the chloral. Dr. J. W. F. Webb,[81] of Liberty, Miss., has known it to diminish and temporarily destroy the sexual appetite, when taken only for a few days. Also in the case of a chloral eater.

Dr. Horatio C. Bigelow,[81] of Washington, D. C., saw “loss of erectile power follow the use for one month of ten grains of the drug, three times daily.” The person was a strong, healthy man, seemingly of good virile power, to whom it had been given for chronic dysentery. He was never so affected before. It was some months before there was any return of power.

Dr. J. H. Nordlin,[82] of Rome, Ga., has used it successfully as an anaphrodisiac, as also a correspondent of the Lancet.[83] Dr. O. F. Ham, of North Barnstead, N. H., writes me of a chloral taker, a lady, whom he has questioned closely. She avers that chloral has absolutely no effect on her sexual appetite, which was never marked.

Sensitiveness of the organs of generation, a kind of mucous membrane hyperæsthesia, has also been noted by Dr. H. H. Doane,[82] of Litchfield, Ohio, as follows:—

“Female, aged forty-two; used chloral for twelve years. Given for insomnia and nervousness of prolapsus uteri, with constipation. Bilious temperament. Dose, twenty grains, four or five times a day. Present condition, prolapsus uteri, obstinate constipation, great loss of flesh and muscular power, appetite poor, stomach weak and tender on pressure; also constant, dull, and sometimes sharp gastric pain. Headache, nervous prostration, loss of mind (general melancholia, with suicidal tendency, if chloral is withdrawn for a few days). No pain in neighborhood of joints, slight dimness of vision accompanying headache. No family history of morphine or opium habit or alcoholism. Extreme sensitiveness of sexual organs.”