Del Medigo had, in fact, very sound and healthy views on religion. Although a warm adherent of Judaism, entertaining respect also for its Talmudic element, he was yet far from indorsing and accepting as truth all that appears in the Talmud. When requested by one of his Jewish disciples, Saul Cohen Ashkenasi, of Candia, to give his confession of Jewish faith, especially his views on the signs which distinguish a true religion, Elias Cretensis issued a small but pregnant work, "The Investigation of Religion" (Bechinath ha-Dath), which gives a deep insight into his methods of thought.

It cannot be maintained that Del Medigo suggested novel trains of thought in his work. In general, the Italians were not destined to endow Judaism with new ideas. Moreover, he occupied the standpoint of belief rather than of inquiry, and his aim was to defend, not to cut new paths. Standing alone in the mental barrenness of his age, Del Medigo's sound views are like an oasis in the desert. He must be credited, too, with having recognized as deformities, and with desiring to remove, the additions to Judaism by Kabbalists and pseudo-philosophers.

Unfortunately, the rabbis who emigrated from Germany to Italy assumed an attitude distinctly hostile to philosophical investigation and its promoters, Elias del Medigo and Messer Leon. With their honest, but one-sided, exaggerated piety, they cast a gloomy shadow wherever their hard fate had scattered them. Fresh storms breaking over the German communities had driven many German Jews, the most unhappy of their race, into transalpine lands. Under Emperor Frederick III, who for half a century had with astounding equanimity beheld most shameless insults to his authority on the part of an ambitious nobility, a plundering squire-archy, a demoralized clergy, and the self-seeking patricians of the smaller towns, the Jewish communities but too often saw their cup of bitterness overflow. Frederick himself was by no means hostile to them. On the contrary, he frequently issued decrees in their favor. Unhappily, his commands remained for the most part a dead letter, and his laxity of rule encouraged the evil-minded to the commission of the most shameful misdeeds. It was dangerous for the German Jews to go beyond the walls of their cities. Every man was their foe, and waylaid them to satisfy either his fanaticism or his cupidity. Every feud that broke out in the decaying German empire brought misery to them.

Among exiles from Mayence were two profound Talmudic scholars. They were cousins, by name Judah and Moses Menz. The former emigrated to Padua, and there received the office of rabbi, while the latter at first remained in Germany, and then passed over to Posen. As the result of expulsion or oppression, many rabbis were emigrating from all parts of Germany, and on account of their superior Talmudic knowledge these German emigrants were elected to the most distinguished rabbinical positions in Italy. They re-indoctrinated with their prejudice and narrowness of vision the Italian Jews, who were making determined efforts to free themselves from the bonds of the Middle Ages.

The most distinguished rabbis of Italy were at that time Judah Menz and Joseph Kolon, and precisely these two were most inimical to any liberal manifestation within Judaism, and most strenuously opposed the advocates of freedom. Joseph ben Solomon Kolon (flourished 1460–1490) was of French extraction, his ancestors having been expelled from France; but he passed his youth in Germany, and belonged to the German school. He subsequently lived with his relatives in Chambéry until the Jews were hunted out of Savoy. With many companions in misfortune he went to Lombardy, where he gained his living by teaching; finally he became rabbi of Mantua. Endowed with extraordinary penetration, and fully the equal of the German rabbis in the depth of his Talmudic learning, Joseph Kolon was celebrated in his day as a Rabbinical authority of the first magnitude, and his academy rivaled the German school itself. He was consulted by both German and Italian communities. On scientific subjects and all matters outside the Talmud he was as ignorant as his German fellow-dignitaries. A resolute, decided nature, Joseph Kolon was a man of rigid views on all religious matters. His ruggedness involved him in unpleasant relations with Moses Kapsali in Constantinople, and in a heated controversy with the cultured Messer Leon in his own community. However well they might agree for a time, Joseph Kolon, the strict Talmudist, and Messer Leon, the cultured man of letters, could not long tolerate each other. When the conflict between them broke out, the whole community of Mantua took sides in their feud, and split into two parties as supporters of the one or the other. The strife at length became so keen that in 1476–1477 Duke Joseph of Mantua banished them both from the city; after which Kolon became rabbi of Pavia.

Still more strained were the relations between the rabbi Judah Menz and the philosopher Elias del Medigo. The former (born 1408, died 1509), a man of the old school, of comprehensive knowledge of Talmudic subjects, and of remarkable sagacity, was most resolutely opposed to scientific progress and freedom in religious matters, and after his expulsion from Mayence transplanted the narrow spirit of the German rabbis to Padua and Italy in general.

The relatively secure and honorable position of the Jews in Italy did not fail to rouse the displeasure of fanatical monks, who sought to cover with the cloak of religious zeal either their dissolute conduct or their ambitious share in worldly affairs. The colder the Christian world grew towards the end of the fifteenth century with regard to clerical institutions, the more bitterly did the monastic orders rage against the Jews. Preaching friars made the chancels ring with tirades against them, and openly advocated their utter extermination. Their most desperate enemy at this time was the Franciscan Bernardinus of Feltre, a worthy disciple of the bloodthirsty Capistrano. The standing text of his sermons was: Let Christian parents keep a watchful eye on their children lest the Jews steal, ill-treat, or crucify them.

He held up Capistrano, the Jew-slayer, as the type and model of a true Christian. In his eyes friendly and neighborly intercourse with Jews was an abomination, a most grievous sin against canonical law. Christian charity, he admitted, directs that Jews, being human, be treated with justice and humanity; but at the same time the canonical law forbids Christians to have any dealings with them, to sit at their tables, or to allow themselves to be treated by Jewish physicians. As the aristocracy everywhere, in obedience to their own interests, took the part of the Jews, Bernardinus inflamed the lower classes against the Jews and their patrons. Because certain Jewish capitalists had been successful, he depicted all Jews as vampires and extortioners, and roused the ill will of the populace against them. "I, who live on alms and eat the bread of the poor, shall I be a dumb dog and not howl when I see the Jews wringing their wealth from Christian poverty? Yea! shall I not cry aloud for Christ's sake?" Such is a fair specimen of his preaching.

Had the Italian people not been actuated by strong good sense, Bernardinus would have become for the Jews of Italy what, in the beginning of the same century, the Dominican, Vincent Ferrer, had been to the Jews of Spain, and Capistrano, to the communities of Germany and the Slav countries. The authorities sorely hindered Bernardinus in his business of Jew-baiting, and his bloodthirsty sermons mostly failed of effect. When he was conducting his crusade in Bergamo and Ticini, Duke Galeazzo, of Milan, forbade him to proceed. In Florence, in fact everywhere in Tuscany, the enlightened prince and the senate took the part of the Jews with vigor. The venomous monk spread the report that they had allowed themselves to be bribed with large sums by Yechiel of Pisa and other wealthy Jews. As Bernardinus was inciting the youth of the city against the Jews, and a popular rising was imminent, the authorities ordered him to quit Florence and the country forthwith, and he was compelled to submit (1487). Little by little, however, by dint of untiring repetition of the same charges, he managed so far to inflame public opinion against the Jews that even the Venetian senate was not always able to protect them. Finally, he succeeded in bringing about a bloody persecution of the Jews, not, indeed, in Italy, but in the Tyrol, whence it spread to Germany.

While Bernardinus was preaching in the city of Trent, he remarked with no little chagrin the friendly relation between Jews and Christians. Tobias, a skillful Jewish physician, and an intelligent Jewess, named Brunetta, were on most friendly terms with the upper classes, enjoying their complete confidence. This roused his ire not a little, and he made the chancels of Trent ring with savage tirades against the Jews. Some Christians called him to account for his hatred of Jews, remarking that though they were without the true faith, those of Trent were worthy folk. The monk replied: "Ye know not what misfortune these good people will bring upon you. Before Easter Sunday is past they will give you a proof of their extraordinary goodness." It was easy for him to prophesy, for he and a few other priests had arranged a cunning plan, which not only brought about the ruin of the community of Trent, but also caused the greatest injury to the Jews of various countries. Chance aided him by creating a favorable opportunity.