Against those unfortunates in Portugal, not only evil-minded men, but nature itself, fought. Soon after their arrival in Portugal, a cruel pestilence began to rage among them, destroying thousands. The Portuguese, who also suffered from the plague, believed that the Jews had brought it into the country; and, indeed, all that they had suffered, the oppressive heat at the time of their going forth, want, misery, and all kinds of devastating diseases, may have developed it. A considerable number of the Spanish refugees died of the plague in Portugal. The population on this account murmured against the king, complaining that the pestilence had followed in the track of the accursed Jews, and established itself in the country. Don João, therefore, had to insist more strenuously than he otherwise would have done upon the condition that all who had settled in Portugal should leave at the expiration of the eight months. At first he put ships at their disposal, at moderate rates of transportation, according to his agreement, and bade the captains treat their passengers with humanity, and convey them whither they wished to go. But these men, inspired by Jew hatred and avarice, once upon the seas, troubled themselves but little about the king's orders, since they had no need to fear complaints about their inhumanity. They demanded more money than had originally been bargained for, and extorted it from the helpless creatures. Or, they carried them about upon the waste of waters till their stock of provisions was exhausted, and then demanded large sums for a fresh supply of food, so that at last the unfortunates were driven to give their clothes for bread, and were landed anywhere in a nearly naked state. Women and young girls were insulted and violated in the presence of their parents and relatives, and disgrace was brought upon the name of Christian. Frequently these inhuman mariners landed them in some desolate spot of the African coasts, and left them to perish from hunger and despair, or to fall a prey to the Moors, who took them prisoners.

The sufferings of the exiled Jews who left Portugal in ships are related by an eye-witness, the Kabbalist, Judah ben Jacob Chayyat, of a noble and wealthy family. The vessel on which he, his wife, and two hundred and fifty other Jews, of both sexes and all ages, had embarked, left the harbor of Lisbon in winter (beginning of 1493), and lingered four months upon the waves, because no seaport would take them in for fear of the plague. Provisions on board naturally ran short. The ship was captured by Biscayan pirates, plundered and taken to the Spanish port of Malaga. The Jews were not permitted to land, nor to set sail again, nor were provisions given them. The priests and magistrates of the town desired to incline them to the teaching of Christ by the pangs of hunger. They succeeded in converting one hundred persons with gaunt bodies and hollow eyes. The rest remained steadfast to their own faith, and fifty of them, old men, youths, maidens, children, among them Chayyat's wife, died of starvation. Then, at last, compassion awoke in the hearts of the Malagese, and they gave them bread and water. When, after two months, the remainder of them received permission to sail to the coasts of Africa, they encountered bitter sufferings in another form. On account of the plague they were not permitted to land at any town, and had to depend upon the herbs of the field. Chayyat himself was seized, and flung by a malicious Mahometan into a horrible dungeon full of snakes and salamanders, in order to force him to adopt Islamism; in case of refusal, he was threatened with death by stoning. These continuous, grinding cruelties did not make him waver one instant in his religious convictions. At last he was liberated by the Jews of a little town, and carried to Fez. There so severe a famine raged that Chayyat was compelled to turn a mill with his hands for a piece of bread, not fit for a dog. At night he and his companions in misery who had strayed to Fez slept upon the ash-heaps of the town.

Carefully as the Portuguese mariners strove to conceal their barbarities to the Jews, their deeds soon came to light, and frightened off those who remained behind from emigrating by sea. The poor creatures, moreover, were unable to raise the necessary money for their passage and provisions. They, therefore, put off going from day to day, comforting themselves with the hope that the king would be merciful, and allow them to remain in Portugal. Don João, however, was not a monarch whose heart was warmed by kindness and compassion. He maintained that more Jews had come into Portugal than had been stipulated for, and insisted, therefore, that the agreement be strictly carried out. Those who remained after the expiration of eight months were made slaves, and sold or given to those of the Portuguese nobility who cared to take their pick from them (1493).

King João went still further in his cruel dealings with the unhappy Spanish Jews. The children of from three to ten years of age whose parents had become slaves, he ordered to be transported by sea to the newly-discovered San Thomas or Lost Islands (Ilhas perdidas), there to be reared in the tenets of Christianity. The weeping of the mothers, the sobbing of the children, the rage of the fathers, who tore their hair in agony, did not move the heartless despot to recall his command. Mothers entreated to be allowed to go with their children, threw themselves at the king's feet as he came out of church, and implored him to leave them at least the youngest. Don João had them dragged from his path "like bitches who had their whelps torn from them." Is it to be wondered at that mothers, with their children in their arms, sprang into the sea to rest united in its depths? The Islands of San Thomas, whither the little ones were taken, were full of lizards and venomous snakes, and inhabited by criminals transported thither from Portugal. Most of the children perished on the journey, or became the prey of wild beasts. Among the survivors it happened that brothers and sisters, in ignorance of their relationship, married each other. Perhaps the king's barbarity to the Jews must be accounted for by the bitter gloom which mastered him at the death of his only legitimate son.

After the death of João II, who sank in wretchedness into his grave (end of October, 1495), he was succeeded by his cousin Manoel, a great contrast in disposition to himself—an intelligent, amiable, gentle-minded man, and a lover of learning. There seemed some prospect of a better star's rising upon the remnant of the banished Jews in Portugal. King Manoel, finding that the Jews had remained in his kingdom beyond the allotted time only from fear of many forms of death upon the ocean, gave all the slaves their freedom. The money which, beside themselves with joy, they offered him for this, he refused. It is true that his ulterior motive, as Bishop Osorius tells us, was to win them over to Christianity by clemency. The Jewish mathematician and astronomer, Abraham Zacuto, who had remained in Lisbon, having come thither from northern Spain, where he had taught his favorite science even to Christians, was made chief astrologer. Zacuto served the king not merely in the latter capacity. Although a man of limited understanding, unable to rise above the superstition of his day, he had sound knowledge of astronomy, and published a work upon that science, besides preparing his astronomical tables. He also invented a correct metal instrument for measuring the altitude of the stars, to replace the clumsy and inaccurate wooden one used hitherto by mariners.

Under King Manoel, in whose reign Portugal's domains were enlarged by acquisitions in India and America, the Jews were able to breathe awhile. It appears that soon after ascending the throne he issued a command that the accusations against them for murdering children should not be recognized by courts of justice, since they were malicious, lying inventions. Nor would he allow the fanatical preaching friars to utter denunciations against them.

Very short, however, was the gleam of happiness for the Jews under Manoel: the somber bigotry of the Spanish court changed it into terrible gloom. No sooner had the young king of Portugal mounted the throne than their majesties of Spain began to entertain the idea of marriage relations with him in order to turn an inimical neighbor into a friend and ally. They proposed marriage with their younger daughter, Joanna, who afterwards became notorious on account of her jealous disposition and her madness. Manoel lent a willing ear to the proposal of an alliance with the Spanish court, but preferred the elder sister, Isabella II, who had been married to the Infante of Portugal, and had soon after become a widow. Isabella had strong repugnance to a second marriage; but her confessor knew how to overrule her objections, and made her believe that if she consented she would have opportunity to glorify the Christian faith. The Spanish court had marked with chagrin and vexation that the Portuguese king had received the Jewish and Mahometan refugees, and King Manoel's friendly treatment of them was a thorn in their flesh. Ferdinand and Isabella thought that by falling in with the Portuguese king's wishes, they would attain their end. They, therefore, promised him the hand of their eldest daughter upon condition that he join with Spain against Charles VII, and send the Jews out of Portugal, both the native and the refugee Jews. The conditions were very disagreeable to King Manoel, who was on good terms with France, and reaped great advantage from the wealth, energy, intelligence, and knowledge of the Jews.

He consulted with his lords and council upon this question, fraught with such importance for the Jews. Opinions upon it were divided. Manoel hesitated for some time, because his noble nature shrank from such cruelty and faithlessness. The Infanta Isabella spoke the deciding word. She entertained fanatical, almost personal hatred against the Jews. She believed or was persuaded by the priests that the misfortunes and unhappiness which had befallen King João in his last days were occasioned by his having allowed Jews to enter his kingdom; and, nourished as she had been at the breast of superstition, she was afraid of ill-luck in her union with Manoel if Jews were permitted to remain in Portugal. What dreary lovelessness in the heart of a young woman! Irreconcilable strife of feelings and thoughts was thus raised in the soul of King Manoel. Honor, the interest of the state, humanity, forebade his proscribing and expelling the Jews; but the hand of the Spanish Infanta, and the Spanish crown were to be secured only by the misery of the Jews. Love turned the balance in favor of hate. When the king was expecting his bride to cross the borders of his kingdom, he received a letter from her saying that she would not set foot in Portugal until the land was cleansed of the "curse-laden" Jews.

The marriage contract between Don Manoel and the Spanish Infanta, Isabella, then, was sealed with the misery of the Jews. It was signed on the 30th of November, 1496, and so early as the 24th of the following month, the king caused an order to go forth that all the Jews and Moors of his kingdom must receive baptism, or leave the country within a given time, on pain of death. In order to relieve his conscience, he showed clemency in carrying his edict into effect. He lengthened the term of their stay until the October of the following year, so that they had time for preparation. He further appointed three ports, Lisbon, Oporto, and Setubal, for their free egress. That he sought to allure the Jews to Christianity, by the prospect of honor and advancement, was so entirely due to the distorted views of the times, that he cannot be held responsible for it; as it was, only a few submitted to baptism.

Precisely Manoel's clement behavior tended to the greater misery of the Jews. Having ample time to prepare for their departure, and not being forbidden to take gold and silver with them, they thought that there was no need to hurry. Perhaps the king would change his mind. They had friends at court who were agitating in their favor. Besides, the winter months were not a good time to be upon the ocean. The majority, therefore, waited until spring. In the meantime King Manoel certainly did change his mind, but only to increase their fearful misery. He was much vexed at finding that so few Jews had embraced Christianity. Very unwillingly he saw them depart with their wealth and their possessions, and sought ways and means to retain them, as Christians, of course, in his own kingdom. The first step had cost him a struggle, the second was easy.