In Spain and Portugal the Marranos held yet more firmly to their visions of Messianic redemption, and to David Reubeni, whom, with or without his consent, they took for a forerunner of the Messiah. Their illusion was so complete that they boldly inaugurated enterprises which could only end in death for themselves. Several Spanish Marranos, condemned to the stake, had curiously enough found a place of refuge in Portugal (in Campo-Mayor), where they were suffered to remain unmolested. A company of young people from among them ventured to attack Badajoz, whence they had fled, for the purpose of rescuing some Marrano women languishing in the Inquisition dungeons. Their irruption greatly alarmed the inhabitants, but they succeeded in rescuing the unfortunate victims. The incident made a great stir in both countries, and led to most prejudicial results for the pseudo-Christians. This occurrence, as well as the denunciation of several Marranos for disrespect to an image of the Virgin Mary, again induced the king to consider the scheme of establishing a court of Inquisition. David Reubeni's favor with the king of Portugal was of brief duration. He was at first received by João III with extraordinary friendliness, and often admitted to audience (when conversation was carried on by means of an Arab and Portuguese interpreter), and received the distinct promise that eight ships and 4,000 firearms should be placed at his disposal to enable his brother, the alleged king of Chaibar, to make war upon the Turks and Arabs, but the king gradually cooled down. Miguel de Silva, Portuguese ambassador at the papal court while David was at Rome, had held the alleged Jewish prince of Chaibar to be an adventurer. He was recalled to Portugal, and opposing the other councilors, who were deluded by David's daring character, made strenuous efforts to deprive him of the king's favor. Moreover, the homage so remarkably and openly offered to him by the Marranos had roused suspicion concerning him. Miguel de Silva, intrusted with the commission to establish the Inquisition in Portugal, pointed out that the king himself, by favoring the alleged Jewish prince, plainly fortified the Marranos in their unbelief, or adherence to the Jewish cause. Then came the circumcision and flight of the royal secretary, Diogo Pires (Solomon Molcho). This occurrence gave great offense at the Portuguese court, and it was insinuated to the king that David had been his abettor.

Thus it came to pass that David Reubeni suddenly received orders to quit Portugal after he had tarried there and been treated with distinction for nearly a twelvemonth. Only two months' grace before embarkation was granted him. The ship that carried him and his retinue was cast away on the Spanish coast, and David was taken prisoner in Spain, where he was forced to appear before the Inquisition. However, before that could take place, Emperor Charles set him free, and David Reubeni betook himself to Avignon, under papal jurisdiction. As soon as King João broke with David Reubeni, every reason for sparing the Marranos vanished. The vacillating king was hard-pressed by the queen, the Dominicans, and some of the nobles, to decide on introducing the Inquisition. The bishop of Ceuta, Henrique, formerly a Franciscan monk and a fanatical priest, brought about the decision. In his diocese of Olivença five new-Christians were suspected of Jewish practices. He made short work of them. Without greatly troubling as to whether the tribunal of the Inquisition was or was not sanctioned by the pope, and legally established by the king, he prepared stakes and fagots, and burnt the victims to death, having condemned them without regular trial (about 1530). The people jubilantly applauded him, and celebrated the murder of these Jewish-Christians with bull-fights. Far from wishing to hide his deed, Henrique boasted of it, and pressed the king to commence in earnest the chastisement of the heretical and sinful new-Christians. João decided to address himself to Pope Clement respecting the organization of commissions of inquiry in Portugal.

But there were still some priests left from the previous reign who loudly raised their voices against this violent treatment of the Marranos. Two especially deserve to have their names made known to posterity—Ferdinand Coutinho, bishop of Algarve, and Diogo Pinheiro, bishop of Funchal. They had been witnesses of the inhuman cruelties with which, under Manoel, the Jews were driven to baptism, and in no way could recognize them as Christians, neither when there was question of punishing them for relapsing into heresy, nor of intrusting them with judicial power or spiritual benefice. Coutinho, untiring in ridicule of the mistaken zeal of the younger priests, reminded the king that Pope Clement VII himself had not long before allowed several Marranos to acknowledge Judaism openly in the very city of Rome. This pope, convinced of the injustice shown to new-Christians, with the consent of the college of cardinals had given them an asylum at Ancona, permitting them freely to confess themselves Jews. In Florence and Venice also they could live without molestation. Nay, the papal consistory itself had given out that the Portuguese Marranos were to be regarded as Jews. He considered, so Coutinho expressed himself in his friendly consideration of the question, that instead of the new-Christians, accused of outraging what Christians hold sacred, the witnesses ought to be punished for bearing false testimony. The new-Christians should be won to the true faith only by gentle means. At length the king decided to submit the question to the pope, who, should he sanction the establishment of the Inquisition, would at the same time absolve him from the promises made to the Marranos. The Portuguese ambassador at Rome, Bras Neto, received orders to obtain a bull to that effect from the pope. But what so easily, by a stroke of the pen, had been conceded to Spain, cost the king of Portugal many efforts and a struggle, and he was never able fully to enjoy his Inquisition.

Now the weak hand of the amiable Kabbalist Solomon Molcho seized the spokes of this revolving wheel. From the East he had gone to Italy to fulfill the Messianic mission with which he was inspired, or with which he was credited. He wished to speak fearlessly before princes, in the capital of Christendom, of the approaching redemption. At Ancona, where he arrived with followers towards the end of 1529, certain malevolent persons, according to his own story, persecuted him. They were in fact prudent men, who were informed of his life in the East, and feared that, as a result of his impetuous striving for martyrdom, evil consequences would ensue for Jews all over the world, or at least for the Marranos in Italy, Portugal and Spain. Molcho, when cited, is understood to have confessed fearlessly that he preferred Judaism because it taught the truth. The bishop of Ancona discharged him as one of the Portuguese Marranos to whom freedom of religious confession had been allowed by the pope and the cardinals, but forbade him to preach against Christianity. Molcho remained some time at Ancona, where his preaching became very popular, even priests and Christians of the higher classes coming to the synagogue. However, he seems to have compromised himself, and in consequence repaired to Pesaro with the duke of Urbino, Francesco Maria della Rovere I, who thought a settlement of Marranos in his little state would be advantageous. But there was no rest for Molcho; he burnt with impatience to be at Rome to prepare the way for the coming of the Messiah, though without any clear conception of what to do. He waited for some prompting from on high, which, he believed, could not fail him. In obedience to a vision he abandoned his retinue at Pesaro, and set out alone on horseback for Rome. At the first sight of the Eternal City his feelings overcame him, for Molcho, like Luther, held Rome to be the seat of anti-Christ; he sank into fervent prayer, imploring redemption and forgiveness of sin for Israel. A voice broke in upon his prayer, predicting in verses of the Bible, "Edom (Rome) shall be the heritage of Israel, his foot shall be unsteady, but Israel will gain the victory." In this mood he entered Rome, and took up his abode at an inn kept by Christians. He put on a tattered suit, blackened his face, wrapped dirty rags around his feet, and leaving his horse and clothes at the inn, he took his stand among the tribe of beggars on the bridge over the Tiber, opposite the pope's palace. This equipment was in accordance with Messianic tradition, which had it that the Messiah would tarry amongst the lepers and ragged beggars of Rome, to be summoned thence to triumph. For thirty consecutive days the Portuguese enthusiast led this miserable existence, neither eating meat nor drinking wine, but contenting himself with the scantiest and poorest fare, and waiting for the prophetic ecstasy.

In this condition of bodily tension and mental exaltation, Molcho fell into a deep sleep, and had a confused dream, noteworthy because part of it was afterwards fulfilled to the very letter. It was predicted in this vision that a devastating flood would break over Rome and a northern country, and his native land be panic-stricken by an earthquake, that when he himself reached his thirtieth year he would be raised to a higher degree, and clad in Byssus, because of his own free will he had devoted himself to death. He would return to Rome, but leave it again before the flood took place. Then the Holy Spirit, the spirit of wisdom and understanding, would rest on the Messianic king, the dead would rise from the dust, and God give His people glory.

Next morning, enfeebled by his long mortification and his troubled sleep, Molcho dragged himself back to his inn, and rested. He laid aside his disguise, and went out to hold converse with Jews (February, 1530). Being still a complete stranger in Rome, and in order to avoid the denunciation of his opponents, he gave himself out as a messenger from Solomon Molcho. In spite of this he was recognized, and denounced to the Inquisition as a seditious Marrano. He had some time previously entered into intercourse with the pope and some of the cardinals, to whom he predicted the flood. Clement VII, who for several years had been drinking of the cup of sorrow, and experiencing humiliations such as had fallen to the lot of few popes before him, who had been forced to crown at Bologna his deadly enemy, Charles V, as king of Italy and emperor of Rome (February 22d–24th, 1530), was but too readily inclined to listen to dreams and visions. Other unknown relations may have existed between the pope and Molcho, in consequence of which the latter was regarded with surprising favor by the pope. Molcho had friends also among the cardinals. Lorenzo Pucci, for example, grand penitentiary of the papal see, who had taken Reuchlin's part against the Dominicans, was attached to him. Hence, while the papal police were lying in wait for Molcho, at the gates of Rome, he escaped over the walls, and hastened to the pope, from whom he obtained a pontifical passport that guaranteed him against harm.

Furnished with this, Molcho came back secretly to Rome, and one Saturday suddenly appeared in the chief synagogue, where, to the astonishment of all present, he preached on a text taken from the prophetical portion. His adherents in Rome increased so largely that he preached in the synagogue every Sabbath until autumn, without meeting with opposition. He inspired his hearers, yet seemed powerless to disarm his opponents. Molcho was the Jewish Savonarola. He spoke with unshakable certainty of his visions, and even announced to the king of Portugal (through the ambassador, Bras Neto) the earthquake which threatened Lisbon, so that precautionary measures might be taken. Molcho was himself so firmly convinced that the flood would come to pass that, when the predicted time approached, he went to Venice. Molcho and David Reubeni, who meanwhile had returned from Avignon to Italy, again met face to face. They looked at each other coldly and with amazement; each expected miracles from the other. Each desired the other to acknowledge his sublime mission. They were both embarrassed. Molcho's eyes were opened on this occasion to the true character of his once-admired master. He no longer believed in Reubeni's ignorance, but felt convinced that, Talmudic and Kabbalistic learning not being in keeping with his character as an Arabian prince, it was assumed by him in order to deceive people. Molcho even recanted his declaration that he was David's emissary. "Before the God of heaven and earth I proclaim the truth, that my circumcision and the abandonment of my country were not counseled by flesh and blood (David), but took place at the express command of God." Molcho was a deluded enthusiast, whereas David was an adventurer intentionally deceiving others. After his unsuccessful attempt to win over the king of Portugal and Charles V to his schemes, David went to Venice with the purpose of influencing the president of that republic, which had close relations with the East. Remarkably enough he found sympathy there; the Venetian senate sent a man well acquainted with the country to question him respecting his plan and means of conquest in the East (1530).

Both Molcho and David were harassed by the more temperate Jews, who apprehended danger for themselves and their religion. While at Venice Molcho was poisoned by Jewish hands, and fell into a dangerous illness.

Meanwhile the inundation of Rome predicted really took place, transforming the city into a stormy lake, and causing great havoc (October 8th, 1530). At the same time a brilliant comet appeared, shooting out rays of light till the heavens seemed about to open. In Portugal the earth shook thrice, and the earthquake destroyed a number of houses in Lisbon, many persons being buried beneath the ruins (January 26th, 1531).

After the inundation of Rome, Molcho again appeared in that city, where he was honored as a prophet. The pope, to whom he had predicted the calamity, seems to have lavished his affections upon him, and he bestowed public marks of honor upon him. The Portuguese ambassador, Bras Neto, told him that if the king of Portugal had known how favored a man in God's sight was Molcho, and how well able to read the future, he would have permitted him to dwell in his dominions. And this was the moment when the ambassador received the mandate from his sovereign to work secretly for a bull from the papal see introducing the Inquisition against the Marranos! A more unfavorable time could not have been chosen. The affair was laid for decision before the grand penitentiary, Cardinal Lorenzo Pucci. But the latter, as well as Pope Clement, influenced by Solomon Molcho, strongly opposed the proposal from the beginning. Pucci straightforwardly said to the Portuguese ambassador, "The king of Portugal, like the king of Spain, is more attracted by the Marranos' wealth than concerned about the orthodoxy of their creed; let him rather leave them free to live according to their own law, and punish only those who, after voluntarily embracing Catholicism, relapse to the Jewish faith." For the moment Bras Neto was powerless. He even feared Molcho's influence with the pope, and kept his doings secret, lest anything come to the ears of the Marranos in Portugal, and they supply Molcho with money wherewith to bribe the pope's retainers to work against the establishment of the Inquisition.