‘Whereas Wm. Boghurst, apothecary at the White Hart, in St. Giles’ in the Fields, hath administered a long time to such as have been afflicted with the plague, to the number of 40, 50, or 60 patients a day, with wonderful success, by God’s blessing upon certain excellent medicines which he hath, as a water, a lozenge, etc. Also an electuary antidote, of but 8d. the oz. price. This is to notify that the said Boghurst is willing to attend any person infected and desiring his attendance, either in city, suburbs or country, upon reasonable terms, and that the remedies above mentioned are to be had at his house or shop, at the White Hart aforesaid.’

Boghurst gives a good deal of information in his book regarding the signs of the disease, and its treatment; and he describes the spread of the disease in London as follows:—

‘The winds blowing westward so long together, from before Christmas until July, about seven months, was the cause the plague began first at the west end of the city, as at St. Giles’, St. Martin’s, Westminster. Afterwards it gradually insinuated and crept downe Holborne and the Strand, and then into the city, and at last to the east end of the suburbs, soe that it was halfe a yeare at the west end of the city before the east end and Stepney was infected, which was about the middle of July. Southwark being the south suburb, was infected almost as soon as the west end. The disease spread not altogether by contagion at first, nor began at only one place, and spread further and further as an eating spreading soare doth all over the body, but fell upon severall places of the city and suburbs like raine, even at the first at St. Giles’, St. Martin’s, Chancery Lane, Southwark, and some places within the city, as at Proctor’s House.’

Dr. Payne writes: ‘It has always been a question whether the repeated recurrences of plague in Europe were to be attributed to re-introduction of the virus from the East, or to a fresh awakening of a virus already endemic,’ and then alludes to Boghurst’s local explanation of the origin of the 1665 plague. He concludes his Introduction by saying: ‘It seems probable that London still contained sufficient plague virus to start a fresh epidemic, when the local and temporary conditions were favourable. The only temporary conditions of this kind that we know of are, first, the rapid growth of population in London, which caused terrible overcrowding, and must have overtasked the ordinary measures of sanitation; and, secondly, the long drought in the spring of 1665, which is referred to by Boghurst. The importance of this latter fact has been explained by Dr. Creighton, in accordance with Pettenkofer’s laws, but, on the other hand, the great plague year of 1625 was remarkably wet. The question is still one for discussion, and it may be left to the judgment of the reader, guided by the valuable materials which Boghurst contributes.’

From 1348 to 1665 plague was continually occurring in London, but it has not appeared since the last date on anything but a small scale.[179] It has been supposed that in the Great Fire the seeds of the disease were destroyed, but this is not a conclusive reason, and fears were expressed as to its possible reappearance in London after the plague of Bombay in 1896-1897; and the plague of Marseilles in the summer of 1720 created a panic throughout Western Europe. Renewed attention was paid to the London plague of 1665, and in 1722 Defoe wrote his renowned Journal of the Plague Year.

We have no thoroughly trustworthy statistics of the earlier plagues, but Dr. Creighton gives particulars of the visitations in London in 1603, 1625 and 1665 in one table:—

Year. Estimated
Population.
Total
Deaths.
Plague
Deaths.
Highest
Mortality
in a Week.
Worst Week.
1603250,00042,94033,347338525 Aug.-1 Sept.
1625320,00063,00141,313520511-18 Aug.
1665460,00097,30668,596829712-19 Sept.

To these may be added that, in 1593, 11,503 persons died of the plague. The figures of 1603 and 1625 in some reports differ from the above.[180]

Some of the plagues devastated the whole country, so that there was no place for the Londoner to fly to for safety, but in others the danger was more generally confined to London. In 1665 there were many places that the Londoner could visit with considerable chance of safety, but Queen Elizabeth in her reign would have none of this moving about. Stow says that in the time of the plague of 1563 ‘a gallows was set up in the market-place of Windsor to hang all such as should come there from London. No wares to be brought to, or through, or by Windsor; nor any one on the river by Windsor to carry wood or other stuff to or from London, upon pain of hanging without any judgment; and such people as received any wares out of London into Windsor were turned out of their houses and their houses shut up.’