The importance of internal trade with New Mexico, and the possibilities of its growth, were first recognized by the United States in 1824, the originator of the movement being Mr. Thomas Hart Benton of Missouri, who frequently, from his place in the Senate, prophesied the coming greatness of the West. He introduced a bill which authorized the President to appoint a commission to survey a road from the Missouri River to the boundary line of New Mexico, and from thence on Mexican territory with the consent of the Mexican government. The signing of this bill was one of the last acts of Mr. Monroe's official life, and it was carried into effect by his successor, Mr. John Quincy Adams, but unfortunately a mistake was made in supposing that the Osage Indians alone controlled the course of the proposed route. It was partially marked out as far as the Arkansas, by raised mounds; but travellers continued to use the old wagon trail, and as no negotiations had been entered into with the Comanches, Cheyennes, Pawnees, or Kiowas, these warlike tribes continued to harass the caravans when these arrived in the broad valley of the Arkansas.

The American fur trade was at its height at the time when the Santa Fe trade was just beginning to assume proportions worthy of notice; the difference between the two enterprises being very marked. The fur trade was in the hands of immensely wealthy companies, while that to Santa Fe was carried on by individuals with limited capital, who, purchasing goods in the Eastern markets, had them transported to the Missouri River, where, until the trade to New Mexico became a fixed business, everything was packed on mules. As soon, however, as leading merchants invested their capital, about 1824, the trade grew into vast proportions, and wagons took the place of the patient mule. Later, oxen were substituted for mules, it having been discovered that they possessed many advantages over the former, particularly in being able to draw heavier loads than an equal number of mules, especially through sandy or muddy places.

For a long time, the traders were in the habit of purchasing their mules in Santa Fe and driving them to the Missouri; but as soon as that useful animal was raised in sufficient numbers in the Southern States to supply the demand, the importation from New Mexico ceased, for the reason that the American mule was in all respects an immensely superior animal.

Once mules were an important object of the trade, and those who dealt in them and drove them across to the river on the Trail met with many mishaps; frequently whole droves, containing from three to five hundred, were stolen by the savages en route. The latter soon learned that it was a very easy thing to stampede a caravan of mules, for, once panic-stricken, it is impossible to restrain them, and the Indians having started them kept them in a state of rampant excitement by their blood-curdling yells, until they had driven them miles beyond the Trail.

A story is told of a small band of twelve men, who, while encamped on the Cimarron River, in 1826, with but four serviceable guns among them, were visited by a party of Indians, believed to be Arapahoes, who made at first strong demonstrations of friendship and good-will. Observing the defenceless condition of the traders, they went away, but soon returned about thirty strong, each provided with a lasso, and all on foot. The chief then began by informing the Americans that his men were tired of walking, and must have horses. Thinking it folly to offer any resistance, the terrified traders told them if one animal apiece would satisfy them, to go and catch them. This they soon did; but finding their request so easily complied with, the Indians held a little parley together, which resulted in a new demand for more—they must have two apiece! "Well, catch them!" was the acquiescent reply of the unfortunate band; upon which the savages mounted those they had already secured, and, swinging their lassos over their heads, plunged among the stock with a furious yell, and drove off the entire caballada of nearly five hundred head of horses, mules, and asses.

In 1829 the Indians of the plains became such a terror to the caravans crossing to Santa Fe, that the United States government, upon petition of the traders, ordered three companies of infantry and one of riflemen, under command of Major Bennet Riley, to escort the annual caravan, which that year started from the town of Franklin, Missouri, then the eastern terminus of the Santa Fe trade, as far as Chouteau's Island, on the Arkansas, which marked the boundary between the United States and Mexico.[16] The caravan started from the island across the dreary route unaccompanied by any troops, but had progressed only a few miles when it was attacked by a band of Kiowas, then one of the most cruel and bloodthirsty tribes on the plains.[17]

This escort, commanded by Major Riley, and another under Captain Wharton, composed of only sixty dragoons, five years later, were the sole protection ever given by the government until 1843, when Captain Philip St. George Cooke again accompanied two large caravans to the same point on the Arkansas as did Major Riley fourteen years before.

As the trade increased, the Comanches, Pawnees, and Arapahoes continued to commit their depredations, and it was firmly believed by many of the freighters that these Indians were incited to their devilish acts by the Mexicans, who were always jealous of "Los Americanos."

It was very rarely that a caravan, great or small, or even a detachment of troops, no matter how large, escaped the raids of these bandits of the Trail. If the list of those who were killed outright and scalped, and those more unfortunate who were taken captive only to be tortured and their bodies horribly mutilated, could be collected from the opening of the traffic with New Mexico until the years 1868-69, when General Sheridan inaugurated his memorable "winter campaign" against the allied plains tribes, and completely demoralized, cowed, and forced them on their reservations, about the time of the advent of the railroad, it would present an appalling picture; and the number of horses, mules, and oxen stampeded and stolen during the same period would amount to thousands.

As the excellent narrative of Captain Pike is not read as it should be by the average American, a brief reference to it may not be considered supererogatory. The celebrated officer, who was afterward promoted to the rank of major-general, and died in the achievement of the victory of York, Upper Canada, in 1813, was sent in 1806 on an exploring expedition up the Arkansas River, with instructions to pass the sources of Red River, for which those of the Canadian were then mistaken; he, however, even went around the head of the latter, and crossing the mountains with an almost incredible degree of peril and suffering, descended upon the Rio del Norte with his little party, then but fifteen in number.