By July, Leonardo had returned with the king and the French army to Milan. Here was planned a great celebration of the French victory over the Venetians. In front of the cathedral, to the delight of the hundreds of spectators, Leonardo devised a mechanical lion scaring a dragon out of an artificial lake into the beak of a cock which picked the dragon’s eyes out. After the festivities Leonardo returned to his everyday work. In time, he had a thriving workshop and as he became more and more preoccupied with his scientific explorations, his art commissions were turned over to his assistants. He did continue, however, to work on the plans for Marshal Trivulzio’s monument and in his preparatory work for this assignment he expanded his notes and drawings of comparative anatomy.

This renewed interest in anatomy led him to attend a lecture in the winter of 1509. The lecturer was Marcantonio della Torre, a young man in his late twenties and one of the best-known anatomists of the times. He had been a professor at the University of Padua, but this city had fallen into the hands of the Venetians. Marcantonio was forced to flee Padua and had settled at Pavia. The two men, when they met, recognized in each other a devotion to science and they began a professional collaboration that grew into a friendship. Leonardo now developed his anatomy studies to the point where he is today recognized as the foremost medical anatomist of the Renaissance.

Returning to his dissections, Leonardo now proceeded to explore the heart and system of veins in the human body. His drawings of the heart are nearly perfect. Indeed, he was probably the first to discover the endocardium membrane that sheathes the valves and sinews of the heart. Also, he pictured and described the moderator band, “the first cause of the motion of the heart.” His work on this organ led him to the doorstep of discovering the circulation of the blood—later to be carried out by William Harvey in the seventeenth century.

Further, Leonardo was the first to accurately draw a representation of the foetus, or unborn child, in the womb of its mother, writing in his notes that, “we conclude therefore, that a single soul governs the bodies and nourishes the two.” In addition, he drew a remarkable picture of the female figure and for the first time accurately placed her organic structure. In his notes, he also pointed the way to the laws governing metabolism when he wrote, “The body of anything whatsoever that receives nourishment continually dies and is continually renewed....” By pouring wax into a hole in the skull he made the first casts of the ventricles of the brain. Several hundred years were to pass before this method was rediscovered.

As Leonardo’s work progressed, his admiration for the complexity of the human body grew. Many times in the middle of explaining a section of anatomy he inserted a sentence or two of wonder or praise at the magnificent creation that is the human being. Indeed, these drawings and notes represent the sum of many, many dissections; moreover, Leonardo had to work under conditions that placed many obstacles in his path—the crude lights and instruments, the difficulties of obtaining corpses and, above all, the opposition of the superstitious and ignorant.

The following year Leonardo entered in his notes, “This winter of the year 1510 I look to finish all this anatomy.” And yet, however sincerely he might express such a wish, Leonardo was a person who was literally never “finished.” The scientific and artistic tasks he had chosen for himself were clearly beyond the limits of any one man. Besides, the pressures of the outside world were once more threatening the peace and quiet of his home and work.

Pope Julius II became increasingly fearful of the French victories over the Venetians. Secretly, he concluded a peace with Venice and, allying himself with his former enemy, he now turned against the French. When the conflict continued, Charles d’Amboise, the patron of Leonardo, was killed at the battle of Correggio. He was replaced by a new French Viceroy, Gaston de Foix. Although the Pope now hired Swiss mercenaries, this invasion from the North was defeated by the young Gaston. Not to be outdone, the Pope then brought in Spanish troops.

In the ensuing bloody battle at Ravenna, the French completely defeated the armies of the Pope and Spain, despite their use of battle-cars armed with razor-sharp sickles on their wheels—strangely like the early inventions that Leonardo designed for Lorenzo de’ Medici! Although the French were victorious, they lost their brilliant young leader, Gaston de Foix, and with him they lost their heart. As a result, they were soon disorganized. The Pope’s armies renewed their attacks, and the French began a long retreat.

Once again the plague infested Milan and Leonardo’s friend, Marcantonio della Torre, died of it. After some futile attempts at recovery, the French fled across the Alps and with them went Marshal Trivulzio. Milan was left temporarily under the martial rule of the Swiss, and Leonardo with only his few apprentices was left again without a patron.

Tired and prematurely old at sixty-one, Leonardo resignedly gathered his possessions together once more and with Francesco de’ Melzi and four of his loyal pupils, he turned his back on Milan for the last time. The date was September 29, 1513. Their destination was Rome.