Function carried to excess may produce waste so great that repair cannot make up for it during the ordinary daily periods of rest; and there may result incapacities of the over-taxed organs, lasting for considerable periods. We know that eyes strained by long-continued minute work lose their power for months or years: perhaps suffering an injury from which they never wholly recover. Brains, too, are often so unduly worked that permanent relaxation fails to restore them to vigour. Even of the motor organs the like holds. The most frequent cause of what is called "wasting palsy," or atrophy of the muscles, is habitual excess of exertion: the proof being that the disease occurs most frequently among those engaged in laborious handicrafts, and usually attacks first the muscles which have been most worked.
There has yet to be noticed another kind of repair—that, namely, by which injured or lost parts are restored. Among the Hydrozoa it is common for any portion of the body to reproduce the rest; even though the rest to be so reproduced is the greater part of the whole. In the more highly-organized Actinozoa the half of an individual will grow into a complete individual. Some of the lower Annelids, as the Nais, may be cut into thirty or forty pieces and each piece will eventually become a perfect animal. As we ascend to higher forms we find this reparative power much diminished, though still considerable. The reproduction of a lost claw by a lobster or crab, is a familiar instance. Some of the inferior Vertebrata also, as lizards, can develop new limbs or new tails, in place of those which have been cut off; and can even do this several times over, though with decreasing completeness. The highest animals, however, thus repair themselves to but a very small extent. Mammals and birds do it only in the healing of wounds; and very often but imperfectly even in this. For in muscular and glandular organs the tissues destroyed are not properly reproduced, but are replaced by tissue of an irregular kind which serves to hold the parts together. So that the power of reproducing lost parts is greatest where the organization is lowest; and almost disappears where the organization is highest. And though we cannot say that in the intermediate stages there is a constant inverse relation between reparative power and degree of organization; yet we may say that there is some approach to such a relation.
§ 63. There is an obvious and complete harmony between the first of the above inductions and the deduction which follows immediately from first principles. We have already seen ([§ 23]) "that whatever amount of power an organism expends in any shape, is the correlate and equivalent of a power that was taken into it from without." Motion, sensible or insensible, generated by an organism, is insensible motion which was absorbed in producing certain chemical compounds appropriated by the organism under the form of food. As much energy as was required to raise the elements of these complex atoms to their state of unstable equilibrium, is given out in their falls to a state of stable equilibrium; and having fallen to a state of stable equilibrium they can give out no further energy, but have to be got rid of as inert and useless. It is an inevitable corollary "from the persistence of force, that each portion of mechanical or other energy which an organism exerts, implies the transformation of as much organic matter as contained this energy in a latent state;" and that this organic matter in yielding up its latent energy, loses its value for the purposes of life, and becomes waste matter needing to be excreted. The loss of these complex unstable substances must hence be proportionate to the quantity of expended force. Here, then, is the rationale of certain general facts lately indicated. Plants do not waste to any considerable degree, for the obvious reason that the sensible and insensible motions they generate are inconsiderable. Between the small waste, small activity, and low temperature of the inferior animals, the relation is similarly one admitting of a priori establishment. Conversely, the rapid waste of energetic, hot-blooded animals might be foreseen with equal certainty. And not less manifestly necessary is the variation in waste which, in the same organism, attends the variation in the heat and mechanical motion produced.
Between the activity of a special part and the waste of that part, a like relation may be deductively inferred; though it cannot be inferred that this relation is equally definite. Were the activity of every organ quite independent of the activities of other organs, we might expect to trace out this relation distinctly; but since increased activity in any organ or group of organs, as the muscles, necessarily entails increased activity in other organs, as in the heart, lungs, and nervous system, it is clear that special waste and general waste are too much entangled to admit of a definite relation being established between special waste and special activity. We may fairly say, however, that this relation is quite as manifest as we can reasonably anticipate.
§ 64. Deductive interpretation of the phenomena of Repair, is by no means so easy. The tendency displayed by an animal organism, as well as by each of its organs, to return to a state of integrity by the assimilation of new matter, when it has undergone the waste consequent on activity, is a tendency which is not manifestly deducible from first principles; though it appears to be in harmony with them. If in the blood there existed ready-formed units exactly like in kind to those of which each organ consists, the sorting of these units, ending in the union of each kind with already existing groups of the same kind, would be merely a good example of Segregation (First Principles, § 163). It would be analogous to the process by which, from a mixed solution of salts, there are, after an interval, deposited separate masses of these salts in the shape of different crystals. But as already said ([§ 54]), though the selective assimilation by which the repair of organs is effected, may result in part from an action of this kind, the facts cannot be thus wholly accounted for; since organs are in part made up of units which do not exist as such in the circulating fluids. We must suppose that, as suggested in [§ 54], groups of compound units have a certain power of moulding adjacent fit materials into units of their own form. Let us see whether there is not reason to think such a power exists.
"The poison of small-pox or of scarlatina," remarks Mr. (now Sir James) Paget, "being once added to the blood, presently affects the composition of the whole: the disease pursues its course, and, if recovery ensue, the blood will seem to have returned to its previous condition: yet it is not as it was before; for now the same poison may be added to it with impunity." ... "The change once effected, may be maintained through life. And herein seems to be a proof of the assimilative force in the blood: for there seems no other mode of explaining these cases than by admitting that the altered particles have the power of assimilating to themselves all those by which they are being replaced: in other words, all the blood that is formed after such a disease deviates from the natural composition, so far as to acquire the peculiarity engendered by the disease: it is formed according to the altered model." Now if the compound molecules of the blood, or of an organism considered in the aggregate, have the power of moulding into their own type the matters which they absorb as nutriment; and if they have the power when their type has been changed by disease, of moulding materials afterwards received into the modified type; may we not reasonably suspect that the more or less specialized molecules of each organ have, in like manner, the power of moulding the materials which the blood brings to them into similarly specialized molecules? The one conclusion seems to be a corollary from the other. Such a power cannot be claimed for the component units of the blood without being conceded to the component units of every tissue. Indeed the assertion of this power is little more than an assertion of the fact that organs composed of specialized units are capable of resuming their structural integrity after they have been wasted by function. For if they do this, they must do it by forming from the materials brought to them, certain specialized units like in kind to those of which they are composed; and to say that they do this, is to say that their component units have the power of moulding fit materials into other units of the same order.
§ 65. What must we say of the ability an organism has to re-complete itself when one of its parts has been cut off? Is it of the same order as the ability of an injured crystal to re-complete itself. In either case new matter is so deposited as to restore the original outline. And if in the case of the crystal we say that the whole aggregate exerts over its parts a force which constrains the newly-integrated molecules to take a certain definite form, we seem obliged, in the case of the organism, to assume an analogous force. If when the leg of a lizard has been amputated there presently buds out the germ of a new one, which, passing through phases of development like those of the original leg, eventually assumes a like shape and structure, we assert only what we see, when we assert that the entire organism, or the adjacent part of it, exercises such power over the forming limb as makes it a repetition of its predecessor. If a leg is reproduced, where there was a leg, and a tail where there was a tail, there seems no alternative but to conclude that the forces around it control the formative processes going on in each part. And on contemplating these facts in connexion with various kindred ones, there is suggested the hypothesis, that the form of each species of organism is determined by a peculiarity in the constitution of its units—that these have a special structure in which they tend to arrange themselves; just as have the simpler units of inorganic matter. Let us glance at the evidences which more especially thrust this conclusion upon us.
A fragment of a Begonia-leaf imbedded in fit soil and kept at an appropriate temperature, will develop a young Begonia; and so small is the fragment which is thus capable of originating a complete plant, that something like a hundred plants may be produced from a single leaf. The friend to whom I owe this observation, tells me that various succulent plants have like powers of multiplication. Illustrating a similar power among animals, we have the often-cited experiments of Trembley on the common polype. Each of the four pieces into which one of these creatures was cut, grew into a perfect individual. In each of these, again, bisection and tri-section were followed by like results. And so with their segments, similarly produced, until as many as fifty polypes had resulted from the original one. Bodies when cut off regenerated heads; heads regenerated bodies; and when a polype had been divided into as many pieces as was practicable, nearly every piece survived and became a complete animal. What, now, is the implication? We cannot say that in each portion of a Begonia-leaf, and in every fragment of a Hydra's body, there exists a ready-formed model of the entire organism. Even were there warrant for the doctrine that the germ of every organism contains the perfect organism in miniature, it still could not be contended that each considerable part of the perfect organism resulting from such a germ, contains another such miniature. Indeed the one hypothesis negatives the other. The implication seems, therefore, to be that the living particles composing one of these fragments, have an innate tendency to arrange themselves into the shape of the organism to which they belong. We must infer that the active units composing a plant or animal of any species have an intrinsic aptitude to aggregate into the form of that species. It seems difficult to conceive that this can be so; but we see that it is so. Groups of units taken from an organism (providing they are of a certain bulk and not much differentiated into special structures) have this power of re-arranging themselves. Manifestly, too, if we are thus to interpret the reproduction of an organism from one of its amorphous fragments, we must thus interpret the reproduction of any minor portion of an organism by the remainder. When in place of its lost claw a lobster puts forth a cellular mass which, while increasing in bulk, assumes the form and structure of the original claw, we cannot avoid ascribing this result to a play of forces like that which moulds the materials contained in a piece of Begonia-leaf into the shape of a young Begonia.
§ 66. As we shall have frequent occasion hereafter to refer to these units which possess the property of arranging themselves into the special structures of the organisms to which they belong; it will be well here to ask by what name they may be most fitly called.
On the one hand, it cannot be in those chemical compounds characterizing organic bodies that this specific property dwells. It cannot be that the molecules of albumin, or fibrin, or gelatine, or other proteid, possess this power of aggregating into these specific shapes; for in such case there would be nothing to account for the unlikenesses of different organisms. If the proclivities of proteid molecules determined the forms of the organisms built up of them or by them, the occurrence of such endlessly varied forms would be inexplicable. Hence what we may call the chemical units are clearly not the possessors of this property.