But not only were there in Greece women physicians like Agamede, who were noted for their general medicinal knowledge and practice, but there were also others who made a specialty of treating ailments peculiar to their own sex. This we learn from a passage in the Hippolytus of Euripides, wherein the nurse of Phædra addressed the suffering queen in the following words:

"If under pains
Thou labor, such as may not be revealed,
To succor thee thy female friends are here.
But if the other sex may know thy sufferings
Let the physician try his healing art."

More positive information, however, is afforded us by the ancient Roman author Hyginus, who, in writing of the Greek maiden, Agnodice, tells us how the medical profession was legalized for all the free-born women of Athens. Instead of a literal translation of Hyginus, the version of his story is given in the quaint language of one Mrs. Celleor, a noted midwife in the reign of James II.

"Among the subtile Athenians," writes Mrs. Celleor, "a law at one time forbade women to study or practice medicine or physick on pain of death, which law continued some time, during which many women perished, both in child-bearing and by private diseases, their modesty not permitting them to admit of men either to deliver or cure them. But God finally stirred up the spirit of Agnodice, a noble maid, to pity the miserable condition of her own sex, and hazard her life to help them; which, to enable herself to do, she apparelled her like a man and became the scholar of Hierophilos, the most learned physician of the time; and, having learnt the art, she found out a woman that had long languished under private diseases, and made proffer of her service to cure her, which the sick person refused, thinking her to be a man; but, when Agnodice discovered that she was a maid, the woman committed herself into her hands, who cured her perfectly; and after her many others, with the like skill and industry, so that in a short time she became the successful and beloved physician of the whole sex."

When it became known that Agnodice was a woman "she was like to be condemned to death for transgressing the law—which, coming to the ears of the noble women, they ran before the Areopagites, and, the house being encompassed by most women of the city, the ladies entered before the judges and told them they would no longer account them for husbands and friends, but for cruel enemies, that condemned her to death who restored to them their health, protesting they would all die with her if she were put to death. This caused the magistrates to disannul the law and make another, which gave gentlewomen leave to study and practice all parts of physick to their own sex, giving large stipends to those that did it well and carefully. And there were many noble women who studied that practice and taught it publicly in their schools as long as Athens flourished in learning."[182]

After the time of Agnodice many Greek women won distinction in medicine, some as practitioners in the healing art, others as writers on medical subjects. Nor were their activities confined to the land of Hellas. They were also found succoring the infirm and instructing the poor and ignorant in Italy, Egypt and Asia Minor. Among these was Theano, the wife of Pythagoras, who, after her husband's death, assumed charge of his school of philosophy, and who, like her husband and teacher, was distinguished for her attainments in medicine. The names of many others occur in the pages of Hippocrates, Galen and Pliny; and frequent references are made to the works and prescriptions of women doctors who enjoyed more than ordinary celebrity during their time. Of these female practitioners many confined their practice to the diseases of women and children, while others excelled in surgery and pharmacy, as well as in general medical practice.

Among the medical women whom antiquity especially honored, particularly during the Greco-Roman period, were Origenia, Aspasia—not the famous wife of Pericles—and Cleopatra, who was not, however, as is often asserted, the ill-fated queen of Egypt. Likewise deserving of special mention was Metradora, of whom there is still preserved in Florence a manuscript work on the diseases of women,[183] and Antiochis, to whom her admiring countrymen erected a statue bearing the following inscription: "Antiochis, daughter of Diodotos of Tlos; the council and the commune of the city of Tlos, in appreciation of her medical ability, erected at their own expense this statue in her honor."

Pliny, the naturalist, felicitates the Romans on having been for nearly six hundred years free from the brood of doctors. These he does not hesitate to berate roundly. His statement regarding the non-existence of physicians, it must be observed, is somewhat exaggerated. It is true that during the first five centuries there were no professional doctors who lived entirely on their practice. There were, however, many men who had by long experience gained an extensive knowledge of drugs and simples, and who were able to dress wounds and treat diseases with considerable success.

The first Greek freeman to practice medicine in Rome was one Archagatos, about two centuries B.C. He was soon followed by one of his countrymen named Asclepiades. These two soon built up a great reputation as successful practitioners, and were held in the highest esteem by the people of Rome. In consequence of this and of the favorable conditions offered foreigners for the practice of the healing art, there was soon a large influx of physicians and surgeons from Greece, not only into Rome but also into other parts of Italy.

Not long after the arrival of Greek doctors in the capital of the Roman world we learn of certain women physicians in Rome who were held in high repute. Among these were Victoria and Leoparda, both mentioned by the medical writer, Theodorus Priscianus. To Victoria, Priscianus dedicates the third book of his Rerum Medicarum, and in the preface to this book he refers to her as one who has not only an accurate knowledge of medicine, but also as one who is a keen observer and experienced practitioner.