1500–1503. Mould-spots (signacula) in Germany and France.
1500. Comet.
1500. Mortality among cattle in Germany.
1502. Very extensive destruction of cultivation in Germany by blights of caterpillars.
1503. Glandular plague, and destructive epidemics in Germany and France.
1504. Plague in Spain.
1504 and 1505. Encephalitis, putrid fever, and malignant pneumonia in Germany.
1505. Plague in Portugal.
1505. First epidemic petechial fever in Italy. The morbid activity of the organism shewed a decided determination towards the skin during all this period.
1505. Moist summer. Lamentable moral state of England.