It would appear that Wren had no world-wide reputation as an architect at the time, but, probably through the instrumentality of his friend Evelyn, he was appointed by the King as assistant to Sir John Denham, the Surveyor-General of Works, and in the opinion of one of his biographers, Lucy Phillimore, "the practical experience learned in the details of the assistant-surveyor's work was afterwards very serviceable to him."

We find him occupied in 1664 in plans for repairing old St. Paul's and in building the Sheldonian Theatre at Oxford, which was finished in 1669. During the plague of 1665 Wren made a tour of the Continent, and there absorbed ideas which fructified in the new style of classical architecture which has made his name famous. During further discussions concerning the much-needed repairs to St. Paul's came the fire of London in 1666. This solved the difficulty, for St. Paul's was left a gaunt skeleton in the City of Desolation. Wren's plans for the rebuilding of the City were accepted by the King, but were never carried out in anything like their entirety. All attempts to patch up the cathedral were abandoned in 1673, and the ground was cleared for the new foundations. The architect and his master mason laid the first stone on June 21, 1675. The cathedral and the story of its building is familiar to us all. The great architect, having drawn the circle for the dome, called to a workman to bring him a piece of stone to mark the centre. The man brought a fragment of an old tombstone on which was the single word "Resurgam." All present took it as a good omen. We all know how the last stone of the lantern was laid thirty-five years afterwards by the architect's own son in the presence of his father. During those thirty-five years the great freemason's hands had been full, and in the City which rose from the ashes of the fire of 1666 no less than fifty-four churches were either built or restored by him. In addition, we find that the rebuilding or restoration of thirty-six halls of the City guilds, as well as upwards of fifty notable buildings—hospitals, colleges, palaces, cathedrals and churches—in London and the provinces, is laid to his credit.

St. Paul's Cathedral, Wren's City churches, and the Monument, would in themselves make London famous amongst the cities of the world. The Monument was erected to commemorate the rebuilding of the City. The inscription thereon absurdly attributes the origin of the fire to the Papists. Pope satirises it in his "Moral Essays":

London's Column pointing to the skies

Like a tall bully lifts the head and lies.

Chief, for beauty, amongst the churches is St. Stephen's, Walbrook. Canova, the great sculptor, after paying a visit to England for the purpose of seeing the Elgin marbles, was asked if he would like to return to the country. "Yes," he replied, "that I might again see St. Paul's Cathedral, Somerset House, and St. Stephen's, Walbrook."

A dozen or more of Wren's churches have been swept off the map of London, in many cases with a wantonness amounting to sacrilege; but we can still rejoice in the possession of such gems as St. Stephen's, Walbrook; St. Nicholas, Cole Abbey; and St. Mary Abchurch, with its flat roof and cupola supported on eight arches. St. Dunstan's in the East, near the Custom House, still stands testifying to the fact that Wren could restore a church without spoiling it. St. Dunstan's, built in the latest style of perpendicular Gothic, was left a mere shell after the fire. Wren added the fine tower, and capped it with the curious and graceful spire supported on flying buttresses. It is said that the architect stood on London Bridge with a telescope anxiously watching the removal of the scaffolding from the spire. It is scarcely credible, however, that such a man should doubt his own powers of building. This legend recalls the story of the building of the Town Hall at Windsor in 1686. The spacious chamber on the street level is used as a corn exchange and above is the great hall. The anxious town councillors declared that the great room above would collapse. Wren knew exactly how much his four walls and great beams could bear, but, to appease the burghers, he promised to place four columns at the intersections of the beams. He purposely built them about two inches short, and, to this day, after the lapse of two hundred and twenty-five years, there is still a two-inch space between the top of each column and the ceiling it is supposed to support. On the exterior of the building are two statues given by Wren in 1707: one of Queen Anne and the other of her Danish consort, Prince George. Our good Christopher could flatter on occasion. The inscription to Prince George in his Roman costume reads, inter alia:

Heroi omni saeculo venerando.

Underneath the figure of Queen Anne is the legend:

Arte tua sculptor non est imitabilis Anna