Summer being well advanced, Sir William Howe made preparations for taking the field. The Royal Highlanders, along with the 13th, 17th, and 44th regiments were put under the command of General Charles Gray. Failing to draw Washington from his secure position at Middlebrook, General Howe resolved to change the seat of war, and accordingly embarked thirty-six battalions of British and Hessians, and sailed for the Chesapeake. Before the embarkation, the Royal Highlanders received one hundred and seventy recruits from Scotland, who, as they were all of the best description, more than supplied the loss that had been sustained.

After a tedious voyage the army, on August 24th, landed at Elk Ferry. It did not begin the march until September 3rd, for Philadelphia. In the meantime Washington marched across the country and took up a position at Red Clay Creek, but having his headquarters at Wilmington. His effective force was about eleven thousand men while that of General Howe was eighteen thousand strong.

The two armies met on September 11th, and fought the battle of Brandywine. During the battle, lord Cornwallis, with four battalions of British grenadiers and light infantry, the Hessian grenadiers, a party of the 71st Highlanders, and the third and fourth brigades, made a circuit of some miles, crossed Jefferis' Ford without opposition, and turned short down the river to attack the American right. Washington, being apprised of this movement, detached General Sullivan, with all the force he could spare, to thwart the design. General Sullivan, having advantageously posted his men, lord Cornwallis was obliged to consume some time in forming a line of battle. An action then took place, when the Americans were driven through the woods towards the main army. Meanwhile General Knyphausen, with his division, made demonstrations for crossing at Chad's Ford, and as soon as he knew from the firing of cannon that lord Cornwallis had succeeded, he crossed the river and carried the works of the Americans. The approach of night ended the conflict. The Americans rendezvoused at Chester, and the next day retreated towards Philadelphia, and encamped near Germantown.

The British had fifty officers killed and wounded and four hundred and thirty-eight rank and file. The battalion companies of the 42nd being in the reserve, sustained no loss, as they were not brought into action; but of the light company, which formed part of the light brigade, six privates were killed, and one sergeant and fifteen privates wounded.

On the night of September 20th, General Gray was detached with the 2nd light infantry and the 42nd and 44th regiments to cut off and destroy the corps of General Wayne. They marched with great secrecy and came upon the camp at midnight, when all were asleep save the pickets and guards, who were overpowered without causing an alarm. The troops then rushed forward, bayoneted three hundred and took one hundred Americans prisoners. The British loss was three killed and several wounded.

On the 26th the British army took peaceable possession of Philadelphia. In the battle of Germantown, fought on the morning of October 4, 1777, the Highlanders did not participate.

The next enterprise in which the 42nd was engaged was under General Gray, who embarked with that regiment, the grenadiers and the light infantry brigade, for the purpose of destroying a number of privateers, with their prizes at New Plymouth. On September 5, 1778, the troops landed on the banks of the Acushnet river, and having destroyed seventy vessels, with all the cargoes, stores, wharfs, and buildings, along the whole extent of the river, the whole were re-embarked the following day and returned to New York.

The British army during the Revolutionary struggle took the winter season for a period of rest, although engaging more or less in marauding expeditions. On February 25, 1779, Colonel Stirling, with a detachment consisting of the light infantry of the Guards and the 42nd, was ordered to attack a post at Elizabethtown, in New Jersey, which was taken without opposition. In April following the Highland regiment was employed on an expedition to the Chesapeake, to destroy the stores and merchandise at Portsmouth, in Virginia. They were again employed with the Guards and a corps of Hessians in another expedition under General Mathews, which sailed on the 30th, under the convoy of Sir George Collier, in the Reasonable, and several ships of war, and reached their destination on May 10th, when the troops landed on the glebe on the western bank of Elizabeth. After fulfilling the object of the expedition they returned to New York in good time for the opening of the campaign, which commenced by the capture, on the part of the British, of Verplanks and Stony Point. A garrison of six hundred men, among whom were two companies of Fraser's Highlanders, took possession of Stony Point. Washington planned its capture which was executed by General Wayne. Soon after General Wayne moved against Verplanks, which held out till the approach of the light infantry and the 42nd, then withdrew his forces and evacuated Stony Point. Shortly after, Colonel Stirling was appointed aide-de-camp to the king, when the command of the 42nd devolved on Major Charles Graham, to whom was entrusted the command of the posts of Stony Point and Verplanks, together with his own regiment, and a detachment of Fraser's Highlanders, under Major Ferguson. This duty was the more important, as the Americans surrounded the posts in great numbers, and desertion had become so frequent among a corps of provincials, sent as a reinforcement, that they could not be trusted on any military duty, particularly on those duties which were most harassing. In the month of October these posts were withdrawn and the regiment sent to Greenwich, near New York.

The winter of 1779 was the coldest that had been known for forty years; and the troops, although in quarters, suffered more from that circumstance than in the preceding winter when in huts. But the Highlanders met with a misfortune that greatly grieved them, and which tended to deteriorate, for several years, the heretofore irreproachable character of the Royal Highland Regiment. In the autumn of this year a draft of one hundred and fifty men, recruits raised principally from the refuse of the streets of London and Dublin, was embarked for the regiment by orders from the inspector-general at Chatham. These men were of the most depraved character, and of such dissolute habits, that one-half of them were unfit for service; fifteen died in the passage, and seventy-five were sent to the hospital from the transport as soon as they disembarked. The infusion of such immoral ingredients must necessarily have a deleterious effect. General Stirling made a strong remonstrance to the commander-in-chief, in consequence of which these men were removed to the 26th regiment, in exchange for the same number of Scotchmen. The introduction of these men into the regiment dissolved the charm which, for nearly forty years, had preserved the Highlanders from contamination. During that long period there were but few courts-martial, and, for many years, no instance of corporal punishment occurred.

With the intention of pushing the war with vigor, the new commander-in-chief, Sir Henry Clinton, who had succeeded Sir William Howe, in May, 1778, resolved to attack Charleston, the capital of South Carolina. Having left General Knyphausen in command at New York, General Clinton with his army set sail December 26, 1779. Such was the severity of the weather, however, that, although the voyage might have been accomplished in ten days, it was February 11, 1780, before the troops disembarked on John's Island, thirty miles from Charleston. So great were the impediments to be overcome, and so cautious was the advance of the general, that it was March 29th before they crossed the Ashley river. The following day they encamped opposite the American lines. Ground was broken in front of Charleston on April 1st. General Lincoln, who commanded the American forces, had strengthened the place in all its defences, both by land and water, in such a manner as to threaten a siege that would be both tedious and difficult. When General Clinton, anticipating the nature of the works he desired to capture, sent for the Royal Highlanders and Queen's Rangers to join him, which they did on April 18th, having sailed from New York on March 31st. The siege proceeded in the usual way until May 12th, when the garrison surrendered prisoners of war. The loss of the British forces on this occasion consisted of seventy-six killed and one hundred and eighty-nine wounded; and that of the 42nd, Lieutenant Macleod and nine privates killed, and Lieutenant Alexander Grant and fourteen privates wounded.