That the policy of the Popes did not change as regards the selection of their physicians on their return from Avignon to Rome, is to be seen from the physician of the Popes whose See was in both places. This was the famous Francis of Siena, who is known best in history as the intimate friend of Petrarch, and who was physician to Pope Gregory XI. and to his successor, Urban VI. He had been a professor of medicine at the University of Pisa, and by special invitation went to fill the same position in the University of the Papal City, and became at the same time the medical adviser of the Popes. His influence on medicine was not very important, but he occupied a very prominent position among the learned men of the time, and his personal prestige did much to add to the dignity of the profession. In our own time, the medical men who have been best known and whose membership in the profession has added greatly to its popular estimation, have at times not been distinguished for great things in medicine. Francis of Siena was such a man, and the fact that he was medical adviser to the Popes at the same time must be counted as an important factor in the evolution of medical dignity.

One of the first writers on medical cases who did not indulge much in theory was Baverius de Baveriis, of Imola, who died about 1480, and who was the physician to Pope Nicholas V. shortly before and after the middle of the fifteenth century. In the light of the fact that a [{214}] recent Papal physician, Dr. Lapponi, has written a book on hypnotism and spiritism, it is interesting to find that his predecessor in the post of Papal Physician four centuries and a half ago, discussed the differential diagnosis of hysteria, catalepsy, epilepsy and syncope. He also discusses certain interesting cases of vertigo due to stomach trouble, and in general anticipates very unexpectedly neurotic conditions that are supposed to have been recognized in medicine much later than his time. Perhaps the most startling thing to be found in his works is his recommendation of iron for chlorosis, which he claimed to have treated with the greatest success by means of this remedy. Of course, there was no idea at the time that chlorosis was due in any sense to a lack of iron in the system, and its value as a therapeutic agent must have come entirely from empiric considerations; but then most of our advances in drug therapeutics have come by no better way.

Another of the distinguished Papal Physicians of the fifteenth century was John of Vigo (1460-1520), who, as Professor Allbutt notes, was attached to the court of the fighting Pontiff, Julius II., and as a consequence saw much of field surgery. His text-book of surgery, printed at Rome in the early part of the sixteenth century, went through an enormous number of editions. No standard surgical treatise had appeared since that of Guy de Chauliac, and Vigo's continued to be the standard for the next full century. He was a shrewd and skilful as well as a learned physician. His surgical acumen deserves to be noted. He recognized that fracture of the inner table of the skull might take place without that of the outer, and made some very practical remarks with regard to gangrene and its causes. He attributed [{215}] gangrene in certain cases to faulty bandaging in fractures, and discussed its origin also as the result of severe cold. He treated syphilis with mercurial inunctions, a practice still followed by the best specialists in this line. His greatest claim to fame, however, is founded on the fact that he was the first to write a surgical treatise on wounds made by firearms.

At this time, during the first half of the sixteenth century, the Papal Medical School begins to assume an importance in the history of medicine which it was to continue to hold for the next two centuries. After the refoundation of the Sapienza by Pope Alexander VI., and its development under Pope Leo X., special care was taken and no expense spared by their successors, to secure the greatest teachers in anatomy in the world for the medical department of the Papal University. At this time all the great physicians were distinguished for their attainments in anatomy, somewhat as in the nineteenth century great physicians obtained their prestige by original work in pathology. The situations in the two centuries had much more in common than the casual reader of history or even the ordinary student of medicine would appreciate. The list of Papal Physicians, then, becomes to a great extent the roll of the professors of anatomy at the Papal University Medical School. The Popes of this period were wise enough in their generation to realize that the men who devoted themselves to original research in increasing the knowledge of the human body, were also those likely to know most about the diseases of the body and their treatment. These scientific anatomists, with the chastening knowledge of the complexity of the human body before them, probably made less claims to power to cure diseases than many an [{216}] enthusiastic therapeutist of the time, who thought, as have representatives of this specialty in every generation, that he has many infallible remedies for the cure of disease, though subsequent generations have not agreed with him.

The true significance of the lives of the men who occupied the post of Papal Physician after this time will be best appreciated from our treatment of them in the chapter on The Papal Medical School. It will be sufficient here simply to recall the names of the distinguished men who, besides being professors in the Papal Medical School, were the medical advisers of the Popes.

The first and most important of the great Renaissance professors of anatomy of the Roman Medical School who were also Papal Physicians was Columbus. He had been Vesalius's assistant at Padua and later his successor. He had lectured also at Bologna. When a special effort was made to give prestige to the University of Pisa, he was tempted by particularly liberal offers to become the professor of anatomy in that city. It was from here, by still more generous patronage, that the Popes obtained him for their medical school. On treating of the Papal Medical School, we shall have more to say of him and his successor in the professorship of anatomy and medicine as well as in the post of Papal Physician, who was the third of the first anatomists of the time--Eustachius. He with Columbus and Vesalius constitute the trinity of great original investigators in anatomy about the middle of the sixteenth century. It is extremely interesting, with the traditions that exist in the matter, to find that the Popes secured two of these great anatomists for their personal physicians as well as for their medical school. The third one, Vesalius, became the body [{217}] physician first to the Emperor Charles V. and then to his son Philip II., whom many would declare to be as Catholic as the Popes themselves in religious tendencies.

After Eustachius came Varolius, whose name is engraved in the history of medicine because the Pons Varolii or bridge of Varolius, an important structure in the brain now often simply called the pons, was named after him. To Varolius we owe one of the earliest detailed descriptions of the anatomy of the brain. He was the Papal Physician to Gregory XIII., who will be remembered as the Pope under whom the reform of the calendar was made by the great Jesuit mathematician and astronomer, Father Clavius. Pope Gregory's enlightened patronage of medicine in the person of Varolius will be better appreciated if we add that he was chosen as Papal Physician when he was not yet thirty years of age, though he had already given abundant evidence of his talent for original investigation in anatomy. He died at the early age of thirty-two, but not until after he had accomplished a life's work sufficient to give him an enduring place in the history of anatomy. After Varolius as Papal Physician came Piccolomini and then Caesalpinus, whom the Italians hail as the discoverer of the circulation of the blood before Harvey, and of whom we shall have much to say in the next chapter. Piccolomini was not as great an original thinker and worker as many of his predecessors and successors, but he was a man whose prestige in medicine was scarcely less than theirs.

That this same liberal patronage of distinguished physicians was continued in the next century may be realized from the fact that Malpighi, the great founder of comparative anatomy, became one of the Papal Physicians. His intimate friend, Borelli, to whom we owe the [{218}] introduction of physics into medicine, had spent some years in Rome, where, having been robbed by his servants, with the consent of the Pope he took up his abode with the Society of the Pious Schools of San Pantaleone. Here he finished his important work De Motu Animalium, in which the principles of mechanics were first definitely introduced into anatomy and physiology. The preface to this book was written by an ecclesiastic, who praises the piety of Borelli during his stay in Rome and chronicles his encouragement by the Popes in his medical work. Malpighi was succeeded as Papal Physician by Tozzi, who is famous for his commentaries on the ancients rather than for original observation, but who was looked upon in his time as one of the most prominent physicians in Italy, and at this period that meant one of the most prominent physicians in the world. At the beginning of the next century, the eighteenth, Lancisi, by many considered the Father of Modern Clinical Medicine, became the Papal Physician.

Among the consultant physicians to the Popes of the eighteenth century, though he never occupied the post of regular medical attendant, was Morgagni. His advice was often sought by a succession of Popes not only with regard to their personal health, but also with regard to the teaching of medicine and other questions of like nature. Virchow has called Morgagni the Father of Modern Pathology, because he was the first to point out, that for a knowledge of disease it is quite as important to know where the disease has been as to try to learn what it has been. All of the Popes, five in number, of the latter part of Morgagni's life were on terms of intimacy with him. Pope Benedict XIV., one of the very great Popes of the century, a native of Bologna, was [{219}] an intimate friend of Morgagni. His scarcely less famous successor, Pope Clement XIII., had known Morgagni before his elevation to the Papacy, and after his election he wrote assuring Morgagni of his continued esteem and friendship, and asks him to consider the Papal palace always open to him on his visits to Rome. In an extant letter Clement praises his wisdom, his culture, his courtesy, his piety toward God, his charity toward men, and holds him up as an example to all others for the special reason that, notwithstanding all his qualities, he had not aroused the enmity or envy of those around him, thus showing what a depth of humanity there was in him in addition to his scientific attainments.

At this time Morgagni was looked upon by all the medical world as probably the greatest of living medical scientists. Visitors who came to Italy who were at all interested in science, always considered that their journey had not been quite complete unless they had had an opportunity of meeting Morgagni. He had more personal friends among the scientists of all the countries of Europe than any other man of his time. The fact that this leader in science should be at the same time a great personal friend of the Popes of his time is the best possible evidence of the more than amicable relations which existed between the Church and medicine during this century. Morgagni's life of nearly ninety years indeed, covers most of the eighteenth century, and is of itself, without more ado, an absolute proof that there was not only no friction between religion and medicine, but shows on the contrary that medical science encountered patronage and encouragement as far as ecclesiastics were concerned, while success in it brought honor and emolument. [{220}] Morgagni's personal relations to the Church are best brought out by the fact that, of his fifteen children, ten of whom lived to adult life, eight daughters became members of religious orders and one of his two surviving sons became a Jesuit. The great physician was very proud and very glad that his children should have chosen what he did not hesitate to call the better part.