The extent over which the sounds may be heard is increased when the lung surrounding the heart is solidified (hepatisation, splenisation, etc.), or when liquid effusion exists in the chest. A liquid but more especially a solid is a better conductor of sound than the spongy lung. Enlargement (hypertrophy) of the heart equally increases the area of sound. The area of sound is lessened by atrophy of the heart, and by an emphysematous condition of the lungs by which the heart is more extensively covered and further separated from the walls of the chest.

The force or intensity of the heart sounds is increased in high fever, in acute inflammation, in increase of the muscular walls of the heart with enlargement of the internal cavities, in functional disturbance from fear or other exciting cause, and in palpitation. Often in a weak and bloodless patient the heart sounds can be clearly heard at several yards distance from the animal. The intensity of the sounds is diminished in debility when not associated with palpitation, in atrophy of the muscular substance of the heart, in hypertrophy of the muscular tissue of the heart with diminution of its internal cavities, in broken wind when the emphysematous lung more completely envelopes the heart, and in cases of extensive liquid effusion into the pericardium which prevents the apex of the heart from striking against the side of the chest.

The regular rythm, normally manifested by the two sounds and the silence, may be modified in the unequal irregular or intermittent contractions of the heart. Küssmaul’s paradoxical pulse is one in which the pulse is more frequent but less full during inspiration than expiration. Seen in weak heart, during recovery from chest diseases, in chronic pericarditis, and when fibrous bands encircle the root of the aorta. Bigeminal and trigeminal when two or three beats follow each other rapidly, and are separated from the preceding and succeeding beats by longer intervals. This occurs in disease of the mitral valve, and in other weak states of the heart. Fœtal heart rythm in which the pause is shortened and the two sounds of the heart are almost identical, is seen in the later stages of fevers, and in extreme dilation. A curious aberration of rythm is the repetition of either the first or second sound. If of the first sound (anapestic bruit) each beat will be accompanied by three sounds the first two of which resemble the first sound of health. If the second sound is repeated (dactylic bruit, bruit de galop) the first sound only will be prolonged and the last two sharp and quick. The repetition of the last sound is probably due to impaired nervous supply which allows the completion of the contraction of the ventricle and the closure of the arterial (semilunar) valves sooner on one side than the other. If due to diminution of the arterial orifice which retarded the emptying of one of the ventricles, the first sound would probably be accompanied by a blowing murmur. If the auriculo-ventricular valves on one side were imperfect, allowing a reflux into the auricle and a more rapid emptying of the ventricle a blowing murmur would equally accompany the first sound. In either of these two last mentioned cases the murmur would mask or hide the first of two doubled sounds.

The repetition of the 1st sound is often due to dilatation of one ventricle, which in consequence is longer in reaching the same sensation of plenitude, and in receiving the stimulus to contraction.

Morbid Sounds. Murmurs. The distinct and superadded sounds heard in disease are usually designated murmurs. They originate in the interior of the heart (endocardial) or externally to the heart (pericardial). The endocardial sounds mostly arise from some abnormal conditions of the valves or orifices and consist in a blowing or rushing noise which usually accompanies or displaces one of the heart sounds, though it may precede or succeed these. The following table modified from that of Bartle and Roger presents at a glance the relations of these different sounds and their significance.

Blowing or Hissing Murmurs.
Blowing murmur before the first sound. Narrowing of the auriculo-ventricular orifice. Vegetations or coagula on the valves.
Blowing murmur with the first sound. Strongest toward the base of the heart. Propagated along the great arteries. Narrowing of the aortic opening.
Strongest toward the apex of the heart. Not propagated in the great arteries. Narrowing of the pulmonary artery or insufficiency of the auriculo-ventricular valves.
Blowing murmur with the second sound. Double rushing sound heard over the great arteries at each beat of the heart. Insufficiency of the arterial (semilunar) valves.
Blowing murmur after the second sound. Double rushing sound in the arteries with each beat of the heart. Aneurism (dilatation of the great aorta.)

From the table it will be seen that each orifice in the heart may become the seat of two perfectly distinct and independent murmurs; one due to constriction of the orifice in which case the sound is produced with the onward progress of the blood wave; and one due to dilatation of the orifice or insufficient closure of it by the valves, when the sound is due to a recoil or regurgitation of the blood. There is a further sound due to mere roughness of the valves in cases of disease when the sound will be with the normal current of blood, though a second or regurgitant hiss is often heard from the valves being at the same time insufficient to close the orifice. Another blowing murmur is usually heard over the heart and coincident with its first sound in the bloodless state (anæmia). This is not necessarily connected with any diseased condition of the heart itself.

The nature of these murmurs differs in special instances. They may resemble the soft whisper of the words who or awe, of the double letter ss, or the single letter r, according as they are soft or hard and purring.

The pericardial murmur, caused by the rubbing of the dry roughened surface of the serous membrane covering the heart on the correspondingly dry rough surface of the same membrane, reflected on the investing sac, resembles that caused by passing the palm of the one hand over the other which lies on the ear. It is distinguished from the friction sound of pleurisy by its coinciding with the movements of the heart and not with those of respiration. It is usually heard alike during the sounds of the heart and during the period of silence or in other words during the movements of contraction and dilatation in that organ.

General Symptoms of Heart disease. In the acute inflammatory affections there are the signs of general constitutional disturbance attending similar affections in other organs. The decision as to the true nature of the disease must be arrived at from the special character of the pulse, heart sounds, etc. as already noticed.