As the case advances it tends to generalization and winds up with the general symptoms predicated above of pulmonary tuberculosis.
Genital Tuberculosis in the bull is associated with nodular swelling of the testicle, epididymus or cord, hydrocele, and exceptionally tubercle on the penis, or in the prostatic sac.
Mammary Tuberculosis. This may be primary and circumscribed under direct infection through a trauma or by the milk ducts, but more commonly it is secondary to generalized tuberculosis. It may be a rather firm, uniform, painless swelling of one or two quarters (usually hind ones) without at first serious interference with milk secretion. As the disease advances, the follicles and ducts being invaded, an irregular knotted condition is developed, the milk becomes pale, watery, semi-coagulated and filled with bacilli, and the climax is reached in a densely indurated condition of the gland. From the first the mammary lymph glands, behind and it may be in front of the organ, become swollen, and they are finally indurated as caseation or calcification ensues. The superficial inguinal glands often participate.
Pharyngeal Tuberculosis. In this rather common localisation the retro-pharyngeal glands and those on the side of the pharynx especially suffer, though the parotidean lymphatic gland and the submaxillary often participate. Enlargement and induration of the tonsils and ulceration of the mucosa may be present. There is distinct swelling of the throat or displacement downward of the larynx, and the enlarged or hard nodular, perhaps even shrunken, glands may often be detected by manipulation. The nose is carried slightly protruded and a stertor or wheeze accompanies the breathing. A glairy liquid may run from the mouth or nose, and in this, bacilli may often be detected under the microscope. The retro-pharyngeal glands are very subject to softening and liquefaction, and in such a case an obscurely fluctuating swelling may be detected above the pharynx when the hand is introduced through the mouth.
This usually terminates in generalized tuberculosis, though it will often remain for a length of time the one appreciable localization.
Cutaneous Tuberculosis. The counterpart of tuberculosis verrucosa of man, this probably usually occurs by direct inoculation in a sore, yet the infection may reach the seat of lesion through the blood. It is usually represented by an irregular clustering warty growth, hanging more or less loosely from the skin and showing at points caseating centres. Bacilli may be recognized under the microscope.
Glandular Tuberculosis. Aside from the tuberculosis of the internal lymph glands already referred to, tubercles may form in any group of lymph glands, causing swelling, induration, fibroid degeneration or tuberculous abscess. Among these may be named the glands in front of the stifle or shoulder, at the root of the ear, beneath the zigoma, in the jugular furrow, the prepectoral, axillary, inguinal, etc.
Tuberculosis of the Brain and Meninges. Disorder of the cerebral functions occurring in generalized tuberculosis may be held to point to this disease. The earlier meningeal symptoms are often those of excitability, timidity, spasms, visual troubles, etc., merging later into vertigo, hebetude, paresis, unsteady gait, local paralysis and coma.
Tuberculosis of the Eye. This has been seen mostly as the result of experimental inoculation, with conjunctival and sclerotic congestion, corneal opacity, and the development of yellowish centres in the iris and choroid, from which the tubercle extends into the chambers.
Tuberculosis of the Heart, Pericardium or Pleura. Tuberculosis of the pleura is usually a concomitant of pulmonary phthisis, yet it may exist for a time independently, and its diagnosis presents serious difficulties. There may be tenderness of the intercostal spaces, a friction sound in case of raw granular surface or vegetations, creaking from false membranes or even flatness low down on percussion. If these escape notice, a short painful cough and slightly hurried breathing under exertion, in the absence of objective symptoms of lung disease, may lead to suspicion, but the true nature of the affection must remain in suspense. It usually leads to pulmonary or glandular (bronchial), and finally generalized tuberculosis.