Mental diseases: a public health problem

by James Vance May

In the meanwhile efforts were being made to ascertain the cause of mental disease by means of pathological researches. Morgagni,[59] one of the earlier investigators, came to the conclusion that the more common lesions were in the pineal gland, although he found some induration of the brain and various other well-defined changes. Arnold (1782) thought that insanity was due to an increased density of the cerebral substance, particularly, according to Tuke, "of those parts of the brain by means of which the soul is connected with the body." Pinel finally concluded that pathology had practically nothing to do with the problem and Esquirol in 1838 wrote very discouragingly on the subject. Early contributions of considerable importance were made, however, by Foville, Bayle, Greding, Calmeil, Guislain, Parchappe and others. These were confined almost entirely to a study of gross or macroscopic lesions of the brain. Griesinger in 1845 reviewed the pathological changes in the nervous system quite thoroughly as far as they were known at that time. It must be admitted that the greater part of our knowledge of the pathology of mental diseases was acquired at a much later date.

A very definite indication of the progress, or lack of progress, made in determining the etiology of the psychoses is the list of causes agreed upon at the International Congress of Alienists[60] in 1867:—1. Physical causes: Artificial deformities of cranium; convulsions of infancy and dentition; cerebral congestion (primary, not that which arises in the course of certain forms of insanity); organic affections of the brain; senility; pellagra; anemia; constitutional syphilis; intermittent fever; typhoid fever; acute rheumatism; gout and chronic rheumatism; organic affections of the heart; pulmonary phthisis; intestinal worms; other acute diseases; other chronic diseases; suppression of the hemorrhoidal flux; menstrual disorders; metastasis; alcoholic drinks; abuse of tobacco; other vegetable poisons; mineral poisons (lead, mercury, coffee, etc.); insolation; intense heat; intense cold; blows and falls upon the head; other traumatic causes. 2. Moral causes: Appertain to religion; education; love (love thwarted, jealousy); family affections; fluctuations of fortune; domestic troubles; pride; disappointed ambition; fright; irritation; anger; wounded modesty; political events; nostalgia; ennui; misanthropy; sudden joy; simple imprisonment; solitary confinement.

In 1897 the New York State Commission in Lunacy in its eighth annual report published an analysis of the assigned causes of insanity given in 39,369 cases admitted from 1888 to 1896. Of these 11,999 were reported as unascertained. In the remaining 27,370 cases the important "assigned causes" in the order of their frequency were as follows: Moral causes (including domestic trouble, loss of friends, business anxieties, pecuniary difficulties, grief, fright, disappointed affections, disappointed ambition, political excitement, religious excitement, etc.) 6,608, intemperance in drink 4,763, hereditary predisposition 2,095, old age 1,723, general ill health 1,681, epilepsy 1,605, ill health following overwork 1,092, masturbation 1,063, puerperal (including childbirth and abortion) 773, traumatic 608, climacteric 502, la grippe 442, sunstroke 402, physical diseases 375, syphilis 368, cerebral diseases 312, intemperance in drink and narcotics 277, congenital defects 223, shock from injury 167, fever 147, uterine and ovarian disease 132, pregnancy 109, privation and overwork 110, etc. These are given in detail not that they throw any light on the question of etiology but that they are quite significant as to the ideas prevalent on this subject only a few years ago. In justice to the Commission in Lunacy attention should be called to the fact that this tabulation does not purport to give actual causes but those officially "assigned" by the examining authorities or others interested. Clouston[61] in 1911, in making a statistical study of 11,346 cases admitted to the Royal Edinburgh Mental Hospital in the course of thirty-five years, enumerated a long list of causes shown in the hospital reports. It is interesting to note that they include nursing, disordered menstruation, self abuse, sexual excess, surgical operations, bronchitis, prostatic disease, lupus, commencing menstruation, transference of morbid action from other organs to the brain, excessive tobacco smoking, chloroform inhalation, excessive number of children, religious excitement, marriage, changes of residence, sedentary habits, political excitement, bad temper, the Queen's Jubilee, etc. As he says, "No other disease has anything like this list of 107 causes. A black and terrible roll it is. Poor humanity has much to contend with to keep sound in mind." Analyzing these statistical findings, Clouston concludes that "bad heredity, congenital defects, and previous attacks are the great predisposing causes, and that alcohol, the crises of life, epilepsy, the various forms of brain poisons and the gross brain and nervous diseases constitute the mass of exciting causes. Together they account for over seventy per cent of the defects and diseases of the mind that come under my observation."

A reference to the statistical reports of the past as published by the hospitals of this and other countries will show nothing radically different until within the last few years. It will readily be observed that fundamentals were almost entirely lost sight of and nonessentials overemphasized. Masturbation, for instance, is often a symptom of dementia praecox and other forms of mental disease, but is not now looked upon as an important etiological factor. The immediate cause, so-called, is usually a mere incident, often not without some significance, but bearing little if any definite relation to the fundamental underlying condition responsible for a mental breakdown. The studies of Meyer, Hoch, Kraepelin, Freud, Jung, Bleuler and many others have shown that in manic-depressive insanity, dementia praecox and various other psychoses we are dealing with very definite constitutional conditions, morbid temperaments, personality defects, etc., which are responsible for the maladjustments leading to the development of psychoses. Financial reverses, domestic difficulties, the death of near relatives, the ordinary hardships and disappointments of life, even ill health, do not as a rule mean the development of a psychosis in the normal, properly balanced individual. In the constitutionally predisposed, the love affair, the loss of a position, the upsetting factor, whatever it may be, is merely the "straw that breaks the camel's back" and is nothing more than an accident of fate, a pure coincidence. Any other comparatively trifling occurrence out of the ordinary, any difficult situation which the makeup of the individual could not adequately meet and react to, would have accomplished the same result. There are, however, of course, certain psychic traumas to which these inadequate personalities are particularly susceptible.

Experience has shown that without any doubt there are conditions for which defective heredity is largely responsible. It is often difficult to determine the actual rôle which this plays in a given case. Efforts have been made to reduce the study of these factors to a definite scientific basis. In 1865 Gregor Mendel,[62] Abbot of Brünn, published an account of a series of experiments made by him with the common pea (pisum sativum) which was destined to revolutionize our views on the subject of heredity. On crossing a tall with a dwarf plant, tall hybrids resulted with no intermediate forms. This inheritance is said to be due to the presence of a definite "determiner" in the germ plasm. All of his hybrids being of the tall variety, he designated that character as the "dominant," the dwarf being spoken of as the "recessive." On the fertilization of these hybrids he obtained another generation, which averages three tall plants to one dwarf. Further investigation showed that the dwarfs always bred true, as did about one out of three of the tall varieties, the remaining two behaving as did the original hybrids and giving three talls to one dwarf. He therefore observed that he was dealing with three varieties of inheritance, the dwarfs which bred true, the talls which bred true and the talls with a fixed proportion of talls and dwarfs. The phenomenon as noted by Mendel is not, however, universal in its application. Curiously enough no attention was given to Mendel's experiments until eighteen years after his death, when his work was rediscovered by de Vries, Correns and Tschermak in 1900.

Davenport[63] has shown that there are six possible matings of germ cells as illustrated by the pigment of the eye:—1. Both parents, pigmented iris (brown eyes) and duplex—all offspring with pigmented iris and duplex; 2. Both parents brown-eyed, one duplex, one simplex—all children brown-eyed, but half simplex; 3. One parent brown-eyed and duplex, the other blue-eyed—all children brown-eyed and simplex; 4. Both parents brown-eyed and simplex—one-fourth of the children brown-eyed and duplex, one-half brown-eyed and simplex, and one-fourth blue-eyed; 5. One parent brown-eyed and simplex, and the other blue-eyed—one-half the children brown-eyed and simplex, the other half blue-eyed; 6. Both parents blue-eyed—all children blue-eyed. It should be explained that a duplex origin means the inheritance of a character from both parents and simplex from only one. The principles of the Mendelian laws of heredity have been applied to a study of the color of the eyes and skin, the color and form of the hair, the stature, body weight and many other family traits such as musical knowledge, ability along artistic and literary lines, mechanical skill, etc. They have also been applied to the study of various diseases, such as Huntington's chorea, hereditary ataxia, deaf-mutism, feeblemindedness, epilepsy and insanity, etc.

Rosanoff[64] and Orr have suggested the following hypothesis relative to the transmission of the neuropathic constitution as based on the Mendelian theory:—1. Both parents being neuropathic, all children will be neuropathic; 2. One parent being normal but with the neuropathic taint from one grandparent, and the other parent being neuropathic, half the children will be normal but capable of transmitting the neuropathic constitution to their progeny, and half will themselves be neuropathic; 3. One parent being normal and of pure normal ancestry, and the other parent being neuropathic, all the children will be normal but capable of transmitting the neuropathic makeup to their progeny; 4. Both parents being normal, but each with the neuropathic taint from one grandparent, one-fourth of the children will be normal and not capable of transmitting the neuropathic makeup to their progeny, one-half will be normal but capable of transmitting the neuropathic makeup, and the remaining one-fourth will be neuropathic; 5. Both parents being normal, one of pure normal ancestry and the other with the neuropathic taint from one grandparent, all the children will be normal; half of them will be capable and half not capable of transmitting the neuropathic makeup to their progeny; 6. Both parents being normal and of pure normal ancestry, all the children will be normal and not capable of transmitting the neuropathic makeup to their progeny.

Just how much importance is to be attached to these theories is a difficult matter to determine. A study of a considerable number of families by Rosanoff[65] would appear to be very suggestive, although his conclusions must be looked upon as fairly conservative:—"On the whole, taking into consideration the limited amount of material as well as the various sources of possible error, the correspondence between the actual findings and theoretical expectation, as shown in the table, must be regarded as strikingly close." On the other hand, as White[66] says, "In dealing with the subject of heredity, however, it must not be forgotten that our ideas are of necessity largely founded upon hypotheses, as biological science has not yet unfolded a sufficient number of facts to make it possible to tell just how much, in any individual case, must be attributed to the inherent qualities of the "germ plasm" and just how much to the influences of environment. The view which is pretty generally admitted among biologists at present is that there is little warrant for the belief in the Lamarckian hypothesis of the inheritance of acquired characters."

The New York statistical tables on heredity were discontinued in 1907, at which time a total of 104,013 cases had been reported. In 31,290 of these no information was available, leaving a total of 72,622, excluding the not insane. A history of insanity was shown in the paternal branch of the family in 8.6 per cent of the ascertained cases, in the maternal branch in 10.1 per cent, in both paternal and maternal in 1.7 per cent, and in collateral branches in eleven per cent,—a total of 31.4 per cent in which some form of heredity was reported. These statistics relate only to insanity in the family history. There were so many sources of inaccuracy that it was not thought worth while to continue these studies after 1907. Comparisons between the heredity of mental cases and that of normal individuals have been rather surprising. Koller, for instance, as quoted by Kraepelin,[67] in a comparison of 370 healthy with a similar number of insane individuals found a history of psychopathic defects in the immediate families of fifty-nine per cent of the former and 76.8 per cent of the latter. Diem[68] in 1905 made an analysis of the family history of 1193 healthy individuals. This was compared with 1850 mental cases. Neuropathic heredity of some kind was found in 78.2 per cent of the mental cases and 66.9 per cent of the healthy individuals. There was, however, a history of mental diseases in the families of 38.3 per cent of the insane patients as compared with 7.1 per cent of the normal individuals. Somewhat different results were noted in a study of the parents. There was a paternal or maternal history of insanity in 18.1 per cent of the families of the mental cases as compared with 2.2 per cent in the cases of the normal individuals. In the direct parentage, Koller found mental diseases in 57.3 per cent of the families of the insane as compared with 28 per cent in the case of normal individuals. Kraepelin states that the influence of the father is greater in heredity than is that of the mother. The father, furthermore, usually transmits to the son while the mother influences the daughter more.