Hamlet replies:

"Give Laertes the cup,
I'll play this bout first; set it by a while."

Hamlet makes another pass and touches Laertes, and the Queen grasps the poison cup in her excitement and drinks to her son.

The King impulsively says:

"Gertrude, do not drink!" (Aside) "It is the
poisoned cup!"

The Queen, as God and Fate would have it, says stubbornly:

"I will, my lord, I pray you pardon me!"

In the third round Laertes wounds Hamlet with the poisoned-pointed rapier, and in the struggle Hamlet grasps Laertes' rapier and in turn wounds his antagonist.

At this moment the Queen falls off her throne, and dying, says to Hamlet:

"O, my dear Hamlet; the drink, the drink; I
am poisoned!"