It is well, one may be inclined to mutter, as one reads this, but how about the color? It may be nearly the same, but certainly there is a difference. In his book "On Generation" Harvey himself describes in more detail the changes which occur in shed blood on standing, and says: "Of the red parts the upper are more florid, those below are blackish." In the same description he refers shortly after to "the florid and ruddy part which is commonly thought to be arterial blood."[89] The words last quoted evidently refer to the upper part of coagulating blood as commonly seen. This in medical practice would be blood drawn from a vein, and Harvey says nothing of arteriotomy in this passage. Indeed, he refers in the context to venesection; and earlier in the same chapter he wrote: "Physicians observe only human blood, and this shed by venesection into a basin, and coagulated."[90]
The foregoing passages show at once that opinions had been clarified very little by the suggestive change of color caused in shed blood by contact with air. Years before, in jotting down his lecture notes, Harvey had noted that the arterial blood is redder;[91] Galen had known it;[92] it must always have been known. In 1649 Harvey wrote:—
"Three things are especially apt to give rise to this opinion of the diversity of the blood: the first is that the blood which is drawn in arteriotomy is more florid....[93] Whenever and wherever blood issues through a narrow orifice it is strained, as it were, and the thinner and lighter part, which usually swims on top and is the more penetrating, is emitted."[94]
A number of observations follow, of appearances noted in nosebleed, in the use of leeches, in cupping, and in blood-letting from veins and arteries. All these appearances are adduced in support of the view that it is the straining of the blood which renders it more florid, and they all show that the brightening of the color of shed blood on exposure to air served only to lead Harvey off on a false scent. Continuing he refers, as follows, to direct inspection of the dissected lungs:—
"The blood is found to be much more florid within the lungs and after it is squeezed out of them, than in the arteries."[95]
A few pages farther on he states, categorically, the false conclusion to which he has been driven, saying:—
"It is no less plain why the blood of the lungs is so ruddy; for it is thinner, because there it is filtered through."[96]
Nothing indicates better Harvey's readiness to minimize the essential differences between venous and arterial blood than a passage in the treatise of 1628, in which he says that, compared with the left ventricle, the right ventricle "is of greater capacity, that it may supply not only matter to the left ventricle, but also nourishment to the lungs."[97] It should be remembered that, in Harvey's day, the so-called bronchial arteries were still unknown, through which the tissues of the lungs are supplied with arterial blood from the aorta.[98] Not only Columbus,[99] but even Galen,[100] had each devised an erroneous way in which to provide the lungs with "spirituous" or "vital" blood, in addition to the venous blood from the right ventricle; but Harvey is obviously content to let the latter suffice for their nutrition.
What has gone before indicates how erroneous it is to speak of the pulmonary transit, as Columbus had set it forth in 1559, nineteen years before Harvey's birth, as though Columbus were in some sort a sharer in the discovery of the circulation. Those who so speak fail to note the difference between blood and the blood. Although Columbus girded at Galen and corrected him, Columbus's pulmonary transit of a fraction of the blood by curing more than one defect of the Galenic doctrine strengthened the erroneous Galenic physiology of the blood-movement. Of these larger features Columbus not only was no enemy, but remained a devoted adherent. His doctrine certainly paved the way for Harvey's, but in no more immediate sense than did Galen's doctrine that blood is naturally contained in the arteries.[80]