On chloroform and other anæsthetics: their action and administration

by John Snow

Pregnancy. I have repeatedly given chloroform at all periods of pregnancy, both for tooth-drawing and more important operations, and I have not met with any ill effects from it in any of the cases.

The Menstrual Period. It is customary to avoid the menstrual period in fixing the time for a surgical operation, when it can be so arranged. There are, however, often reasons for not waiting over this period, and under such circumstances, I do not know any objection to the inhalation of chloroform. I have administered it frequently during the menstrual period, and have seen no ill effects from it. I have observed that there is a little more tendency to slight hysterical symptoms, during its inhalation at this period, than when the same patients inhale it at other times, which is what we might expect.

Diseases of the Lungs. Affections of the lungs sometimes cause a little difficulty and delay in the administration of chloroform, as the vapour is liable to excite coughing when the mucous membrane of the air-passages is irritable. The inconvenience is, however, confined to the time of inhalation, for the cough is generally relieved afterwards.

I have given chloroform for surgical operations in many cases where phthisis was present, and in several patients who had suffered from hæmoptysis, and have not seen any ill effects from its use in these cases. Chloroform has indeed often been inhaled with advantage to relieve the cough in consumption. The cases of chronic bronchitis in which chloroform is administered for surgical operations are still more numerous. The effects I have observed have been coughing at the time of inhalation, and very often a relief of the cough afterwards. Some of the patients had emphysema of the lungs. It is scarcely necessary to allude, in this place, to acute diseases of the lungs, as surgical operations are not performed during their continuance, but from the fact of chloroform being inhaled occasionally in the treatment of these affections, it is evident that they would cause no obstacle to its employment.

Disease of the Heart. There is a very general impression that the use of chloroform is unsafe when disease of the heart exists, more particularly, fatty degeneration of that organ. This belief has been encouraged by the circumstance that this affection has been present in a few of both the real and alleged deaths from chloroform; and also by the fact that, in the accidents that have been really due to chloroform, the heart has been the organ on which it has exerted its fatal influence. When we come to investigate these cases, however, we shall find reason to conclude that the heart has probably been diseased in quite as great a proportion of the patients who have taken chloroform without ill effects, as in those who have succumbed under its influence. As regards my own practice, indeed, the only case in which death could in any degree be attributed to the chloroform, was one in which there was extreme fatty degeneration of the heart; but, on the other hand, I have given chloroform in numerous cases without ill effects where the symptoms of this, as well as other affections of the heart, were present in a very marked degree. Indeed, I have never declined to give chloroform to a patient requiring a surgical operation, whatever might be his condition, as I early arrived at the conclusion that this agent, when carefully administered, causes less disturbance of the heart and circulation than does severe pain. Whenever I have had an opportunity of seeing an operation performed without chloroform, I have carefully observed the pulse, and although none of these operations have been of a very severe nature, I have found the circulation to be much more disturbed than it would have been by chloroform carefully administered. The pulse in most of these cases has been excessively frequent during the operation, and in some instances it has intermitted to an unusual extent.

In one instance, I had an opportunity of witnessing a similar operation on the same patient, first without chloroform, and afterwards under the influence of this agent. On January the 6th, 1855, Mr. Fergusson performed lithotrity, in King’s College Hospital, on a man, aged fifty-one. He generally directs chloroform to be administered in lithotrity, but in this instance he omitted to do so, as he thought that the bladder was not very irritable, and that the patient would not suffer much. I began to feel the pulse just when the patient saw the lithotrite about to be introduced. It was 120 in the minute. As soon as the instrument was introduced, the pulse increased to 144, and immediately afterwards it became uneven, irregular, and intermitting. I could not count more than three or four beats at a time; and, occasionally, when the pain seemed greatest, and the man was straining and holding his breath, the pulse was altogether absent for four or five seconds. In order to ascertain whether the absence of pulse at the wrist might not depend on the pressure of the muscles of the arms, caused by grasping the table, I applied my ear to the chest, and found that there was no sound whatever to be heard during the intervals when the pulse was imperceptible. It was evident that the patient held his breath till the right cavities of the heart became so distended as to stop the action of that organ till the respiration returned. The man did not complain or cry out during the operation. A week afterwards the lithotrity was repeated, but on this occasion I administered chloroform. The pulse was about 120 in the minute when the patient began to inhale the chloroform, but it became slower as he was made unconscious, and it was regular and natural during the operation. It was only towards the end of the operation, when the effect of the chloroform was allowed to diminish, and when the man began to strain a little, though not yet conscious, that the pulse intermitted slightly, passing over a single beat occasionally. There were none of the long intermissions of the pulse observed on the former occasion.

It is very evident that if the above mentioned patient had been the subject of any affection of the heart which weakened or embarrassed its action, he would have run a much greater risk from the pain of the first operation, than from the inhalation of chloroform in the second one.

In a few of the patients having the arcus senilis of the cornea, a weak, intermitting, or irregular pulse, and other signs of fatty degeneration of the heart, there have been a feeling of faintness and a tendency to syncope, as the effects of the chloroform were subsiding, especially when the operation had been performed in the sitting posture; but these symptoms have soon subsided, in all the cases I have met with, on placing the patient horizontally, with or without the help of a little ammonia to the nostrils.

Cerebral Disease. Affections of the head offer no obstacle to the administration of chloroform. I have given it to several patients who had suffered previously from an attack of apoplexy. Some of them still retained the paralysis resulting from their attack, but the chloroform has not been attended or followed by ill effects in any of these cases. The following case, in which alarming head symptoms had existed a few hours before the inhalation of chloroform, cannot fail to be interesting.

The 31st of October, 1854, was appointed by Mr. Fergusson to perform lithotrity on a gentleman, seventy-eight years of age, who had a phosphatic calculus in his bladder. He was a patient of Mr. Propert, and Mr. Fergusson had removed a similar calculus by lithotrity, and I had given him chloroform at each of the operations, and it was arranged that he should have chloroform on the present occasion. Mr. Propert informed Mr. Fergusson and me, on our arrival, that his patient had had an attack the night before resembling apoplexy; he had been insensible, the breathing had been stertorous, the pupils dilated, and the face very red and congested. Mr. Propert had caused him to be cupped to fourteen ounces, and had given him twenty grains of calomel in the course of the night, and in the morning he was as well as usual, and remained so at the time of our visit. We considered the case with Mr. Propert, and as there were reasons for not postponing the operation, it was determined that he should inhale the chloroform rather than be subjected to the pain. The vapour acted very favourably; he recovered his consciousness a few minutes after the operation, and expressed himself as feeling quite well.